Home › Forums › Main Forum › Patient Stories › Sofosbuvir Daclatasvir
- This topic has 17 replies, 6 voices, and was last updated 8 years, 12 months ago by emilio.
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14 September 2015 at 1:46 pm #1261
Dear Dr. Freeman,
How do you encapsulate these Dac-fillers? What are the ingredients?
What is needed for Sofosbuvir? How many grams? Ingredients? Is this also possible?
Thanks for answering!
Live life
14 September 2015 at 3:49 pm #1262Hi Live life
I am glad you posted this because I also have questions about encapsulating the Mesochem APIs.
1.
What size capsules are needed for 400mg sofosbuvir / 60mg daclatasvir?
2.
I am doing it myself and I understand that fillers are not required. Is that correct?
3.
Once encapsulated, do the capsules need to be stored in the fridge? Once stored correctly, can they be expected to remain viable for 6 months from date of encapsulation, provided that the dry bag of powder as shipped had an expiry date of at least one year?Thanks,
dointime14 September 2015 at 4:06 pm #1263I’m happy your happy!
Does the powder has to stay in the fridge as well for now?????
Many Thanks!
15 September 2015 at 1:55 am #1267Hi
I will wait for the good doctor to answer this however I’ve had the same conversation with him at my last skype visit. Apparently there are options here but best to use a vegetable extract filler and can be compounded using digital scales and filler kits. Really fiddly but can be done, for $70AU I’m having mine done by a compound chemist. Re the filler name eludes my brain atm and with these drugs there is no need to use with fats for better absorption like with ribavirin and other meds, that’s assuming you’re not using ribavirin.. Storage I believe is room temperature within reason but like I said, James will get back to you on this. Em
7 October 2015 at 1:51 pm #1975Hello! It’s Life again!
So were you able to encapsulate?
Have everything since this week, just don’t know where to start with ingredients (where to buy)Could we get in contact, somehow….
Thanks for replying!!
13 October 2015 at 3:18 am #2206I put daclatasvir and sofosbuvir together in the same capsule, whether it is a problem?????
13 October 2015 at 3:28 am #2207I don’t think it would be an issue as long as you’ve got the measurement/mix right. I’m downing both at the same time so same same. Em
13 October 2015 at 3:43 am #2210I just thought I’d have to throw it and buy a new API
13 October 2015 at 11:48 am #2221was it mixed to a ratio of 400 sofo to 60mg dac before you capped them? Or are we talking 50/50? That wouldn’t work but the previous would. Em
15 October 2015 at 2:18 pm #2284We have been doing accelerated stability testing on this and it seems fine.
Do not worry, as soon as medications arrive in stomach they mix freely anyway.
YMMV
15 October 2015 at 9:36 pm #229115 October 2015 at 9:39 pm #229216 October 2015 at 12:31 pm #2320all good mate, start eating and getting better
16 October 2015 at 12:43 pm #2321We have seen quite a lot of their product from at 6 different batches (when last I looked) and it has been consistently good in terms of closely matching our reference standards.
YMMV
16 October 2015 at 6:19 pm #2339 -
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