Mavyret & DayQuil & cough syrup

This topic has 2 replies, 3 voices, and was last updated 5 years, 7 months ago by Dr James.

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2 March 2019 at 7:05 pm #29007
Lonnie84
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@lonnie84
Wondering if it’s safe to take DayQuil or tussin cough syrup for my cold with my mavyret I’ve been trying to see if there’s any interaction and cant find anything
2 March 2019 at 11:58 pm #29009
Wlodek
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@wlodek
https://www.hep-druginteractions.org/checker

No Interaction Expected

Glecaprevir/Pibrentasvir

Dextromethorphan

Summary:

Coadministration of dextromethorphan (30 mg single dose) and glecaprevir/pibrentasvir (300/120 mg once daily) decreased dextromethorphan Cmax and AUC by 30% and 25% (n=12). This was not clinically significant and no dose adjustment is required.

Description:

Drug-drug interaction studies were performed with dextromethorphan and showed no clinically significant interactions with Maviret.
Maviret Summary of Product Characteristics, AbbVie Ltd, July 2017.

No dose adjustment is required when Mavyret is coadministered with dextromethorphan. Coadministration of dextromethorphan (30 mg single dose) and glecaprevir/pibrentasvir (300/120 mg once daily) decreased dextromethorphan Cmax and AUC by 30% and 25% (n=12).
Mavyret Prescribing Information, AbbVie Inc, August 2017.
4 March 2019 at 2:50 am #29010
Dr James
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@fixhepc
Hello Lonnie84,

Wlodek has pointed you to the https://www.hep-druginteractions.org/checker which lets you check most interactions.

Maviret is Glecaprevir/Pibrentasvir

VICKS ® DayQuil ™ Cough – Cough & Congestion is Guaifenesin + Dextromethorphan

Guaifenesin is not covered but will be fine. Dextromethorphan is and it’s fine to take with Maviret.

Best of luck with your treatment. Maviret is a great combination, see: https://fixhepc.com/blog/item/132-maviret-mavyret-is-an-awesome-drug-for-hcv.html

YMMV
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