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Genotype 3's info, updates corner
Good for you!!!!!
ALT 101 AST 71
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000
Started generic Epclusa Sep. 23, 2017
4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.
Thank you Jesus.
Thank you Dr. James
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Good news Donna another one cured
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated
GT 3 - about 28 yrs with HCV
I can't wait to start. I want to get my fibroscan and have doctor prescribe so I can get in on the studies. I have had most tests done. Thankfully the two listed on this site are good and affordable. I have type 3A. My scan is in one month. It is cheaper for me to go to Canada to get this as I do not need doctor appointments for it. I hope to see updates on your progress.
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Hi Gypsy, This is an exciting time for you, you must be full of anticipation. Good that you do not have to wait long until you get your fibroscan, you're fortunate to be able to access that technology. As a longtime HCV+ve person who endured multiple old liver punch biopsies, I was relieved when the far more comfortable fibroscanning became available.
I am looking forward to reading your progress reports over the next weeks and months. You are on your way!
G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
Good to see that you are heading towards your start date. I know what you mean about not wanting to wait. Once I heard about the treatment and how quickly, easily and cheaply I could access it I couldn't wait to just do it. Good luck and I'm looking forward to hearing about how you are travelling.
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
I got my Rx through Dr . Freeman and they were shipped and are now in New York (customs I suppose). Fibroscan is this next week. Looking forward to results. Going to Canada which is at least a 7 hr trip or longer. Cant wait to get started.
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Hi James Feemann
Treatment of GT3 in Denmark:
I have a question for you regarding genotype 3
Have the Danish health authorities paid the following treatment:
Sofosbuvir 400 mg & Velpatasvir 100 mg or
Sofosbuvir 400 mg & Daclatasvir 60 mg.
Are there any studies whether there are differences in the effect of the two types of treatment?
Probably infected 30 years ago Genotype: 1a
Fibroscan 4,8 - 18 january 2017
Virus in the blood 18 January 2017 10.400000 / Alat 102
Started treatment January 19, 2017
Feb.15 - Alat 76 - virus: UNDETECTED
March 15 - Alat 34 - virus UNDETECTED
April 12 - Alat 40 Asat 34 - virus UNDETECTED / Taking the last pill
May 10 SVR4 - Alat 36 -virus UNDETECTED
July 5 SVR12 - Fibroscan 3,8 Alat 39 - virus UNDETECTED
Sep. 27 SVR24 - ALAT 24- virus UNDETECTED
Marts 14 - 2018 SVR48 - ALAT 26- virus UNDETECTED
Yes, there are studies. You want page 18 of the EASL Guidelines (see PDF) that reports the major studies used for the guidelines and provides references for them you can then look up.
Short version: slides.hcvonline.org/uploads/194/astral3.pdf
Long version: www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article
SOF+DCV: ALLY-3 and ALLY-3+
Short version: slides.hcvonline.org/uploads/164/ally3.pdf
Long vesion: www.ncbi.nlm.nih.gov/pmc/articles/PMC4409820/
There is another bigger SOF+DCV trial here: fixhepc.com/forum/gt3/369-gt3-high-svr-r...ith-daclatasvir.html which includes a PDF of the results. It does not have a funky name AFIK.
You may notice that the results for SOF+DCV vary a bit and include similar optimistic numbers to SOF+VEL
Now this table is interesting (and you won't easily find it). It comes from Abbvie who were talking about how good G/P is (previously called ABT-493/ABT-530). GS-9857 is Voxilaprevir in case you're wondering.
In theory Velpatasvir should be better - It has an EC50 of 20 vs 530 for daclatasvir, but only about 25% gets absorbed so that robs it of part of the 26.5x theoretical edge, dropping it to say 7x, but then the dose is 100 mg vs 60 mg so that pushes it up to about 10x.
Now resistance comes in 10x, 100x and 1000x strengths so 10x is just enough to probably make a real difference for a few patients.
I have no doubt that 16 weeks SOF+DCV works better in GT3 patients than 12 weeks, so that is a factor.
I am genotype 3A and have been generic epclusa only a little over a week. My fibroscan looked normal. The first few days I felt kind of off but take it at night now and am noticing improvement in energy off and on.