Welcome, Guest

TOPIC: Genotype 3's info, updates corner

Genotype 3's info, updates corner 4 months 5 days ago #23987

Donna
Offline
Senior Member
nothing is as I expected it to be.....
Posts: 70
Thank you received: 213
Karma: 3

Just had my results 14 weeks EOT
Negative for Hep C
Thanks Dr Freeman

3a
F1- F2
Pre Tx = ALT 66 AST 42. VL 2.8
Pre Tx = Fibro 7.5 & 6.4

Sof/Dac 5/9/16
ALT 20 ( 26/9/16)
VL Not Detected(29/9/16)

ALT 11 (31/10/16)
VL Not Detected (31/10/16)

ALT 14 (6/3/17) VL NOT DETECTED!!!!
Fibro 3.4 (20/3/17)

ALT 13 (19/6/17)
VL NOT DETECTED !!!!!

The administrator has disabled public write access.

The following user(s) said Thank You: James-Freeman-facebook, klhilde, coral, Paul-Jarman-facebook, Gaj, splitdog, Hazel, Mnem

Genotype 3's info, updates corner 4 months 5 days ago #23988

splitdog
Offline
Platinum Member
Posts: 332
Thank you received: 618
Karma: 9

Good for you!!!!!

This email address is being protected from spambots. You need JavaScript enabled to view it.

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000
1 week later= 20,741,477

I know I will be cured.
Thank you Jesus.

The administrator has disabled public write access.

The following user(s) said Thank You: James-Freeman-facebook

Genotype 3's info, updates corner 4 months 4 days ago #24002

Paul-Jarman-facebook Offline Moderator The gypsy woman told my mother Before I was born Posts: 382 Thank you received: 659 Karma: 9	Good news Donna another one cured
	Two time relapser. SVR 4 achieved 12/16 at last SVR 12 achieved 22/02/2017 The Bastard has been defeated GT 3 - about 28 yrs with HCV The administrator has disabled public write access. The following user(s) said Thank You: James-Freeman-facebook, Donna

Genotype 3's info, updates corner 3 months 1 day ago #24274

gypsy Offline Senior Member Posts: 55 Thank you received: 87 Karma: 1	I can't wait to start. I want to get my fibroscan and have doctor prescribe so I can get in on the studies. I have had most tests done. Thankfully the two listed on this site are good and affordable. I have type 3A. My scan is in one month. It is cheaper for me to go to Canada to get this as I do not need doctor appointments for it. I hope to see updates on your progress.
	The administrator has disabled public write access. The following user(s) said Thank You: James-Freeman-facebook, coral, Gaj, Iain, Mnem

Genotype 3's info, updates corner 3 months 22 hours ago #24275

Mnem
Offline
Senior Member
the fox knows many things, but the hedgehog knows one big thing
Posts: 56
Thank you received: 109
Karma: 0

Hi Gypsy, This is an exciting time for you, you must be full of anticipation. Good that you do not have to wait long until you get your fibroscan, you're fortunate to be able to access that technology. As a longtime HCV+ve person who endured multiple old liver punch biopsies, I was relieved when the far more comfortable fibroscanning became available.
I am looking forward to reading your progress reports over the next weeks and months. You are on your way!

G2, infected ~1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990's
Treatment naive. Fibroscan & bloods all normal ranges
Viral load 7million
began Redemption trial4 Sof/Vel 2017
week4 - virus UND
week12 EOT - UND *)*
now marching to SVR12

Last Edit: 2 months 3 weeks ago by Mnem. Reason: spellings

The administrator has disabled public write access.

The following user(s) said Thank You: James-Freeman-facebook, Gaj, Iain, gypsy

Genotype 3's info, updates corner 3 months 1 hour ago #24284

coral
Offline
Platinum Member
Posts: 406
Thank you received: 1099
Karma: 14

Hi Gypsy,

Good to see that you are heading towards your start date. I know what you mean about not wanting to wait. Once I heard about the treatment and how quickly, easily and cheaply I could access it I couldn't wait to just do it. Good luck and I'm looking forward to hearing about how you are travelling.

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 UND Hooray...

The administrator has disabled public write access.

The following user(s) said Thank You: James-Freeman-facebook, Hazel, gypsy

Genotype 3's info, updates corner 2 months 2 days ago #24493

gypsy Offline Senior Member Posts: 55 Thank you received: 87 Karma: 1	I got my Rx through Dr . Freeman and they were shipped and are now in New York (customs I suppose). Fibroscan is this next week. Looking forward to results. Going to Canada which is at least a 7 hr trip or longer. Cant wait to get started.
	The administrator has disabled public write access. The following user(s) said Thank You: Mnem

Genotype 3's info, updates corner 2 months 2 days ago #24494

gypsy Offline Senior Member Posts: 55 Thank you received: 87 Karma: 1	Yay!!Yahoo!! Congratulations!
	The administrator has disabled public write access.

Genotype 3's info, updates corner 1 month 4 weeks ago #24503

Gert
Offline
Senior Member
Born in Copenhagen, live in AArhus Denmark
Posts: 54
Thank you received: 119
Karma: 2

Hi James Feemann

Treatment of GT3 in Denmark:

I have a question for you regarding genotype 3
Have the Danish health authorities paid the following treatment:
Sofosbuvir 400 mg & Velpatasvir 100 mg or
Sofosbuvir 400 mg & Daclatasvir 60 mg.

Are there any studies whether there are differences in the effect of the two types of treatment?

greeting
Gert

Probably infected 30 -35 years ago Genotype: 1a
Fibroscan 4,8 - 18 january 2017
Virus in the blood 18 January 2017 10.400000 / Alat 102
Started treatment January 19, 2017
February 15 - Alat 76 - virus: UNDETECTED
March 15 - Alat 34 - virus UNDETECTED
April 12 - Alat 40 Asat 34 - virus UNDETECTED / Taking the last pill

May 10 SVR4 - Alat 36 -virus UNDETECTED
July 5 SVR12 - Fibroscan 3,8 Alat 39 - virus UNDETECTED
September 27 SVR24

The administrator has disabled public write access.

Genotype 3's info, updates corner 1 month 4 weeks ago #24506

James-Freeman-facebook
Offline
Platinum Member
Posts: 1307
Thank you received: 5185
Karma: 72

Hello Gert,

Yes, there are studies. You want page 18 of the EASL Guidelines (see PDF) that reports the major studies used for the guidelines and provides references for them you can then look up.

SOF+VEL: ASTRAL-3

Short version: slides.hcvonline.org/uploads/194/astral3.pdf
Long version: www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article

SOF+DCV: ALLY-3 and ALLY-3+

Short version: slides.hcvonline.org/uploads/164/ally3.pdf
Long vesion: www.ncbi.nlm.nih.gov/pmc/articles/PMC4409820/

ALLY-3+ www.ncbi.nlm.nih.gov/pubmed/26822022

There is another bigger SOF+DCV trial here: fixhepc.com/forum/gt3/369-gt3-high-svr-r...ith-daclatasvir.html which includes a PDF of the results. It does not have a funky name AFIK.

You may notice that the results for SOF+DCV vary a bit and include similar optimistic numbers to SOF+VEL

Now this table is interesting (and you won't easily find it). It comes from Abbvie who were talking about how good G/P is (previously called ABT-493/ABT-530). GS-9857 is Voxilaprevir in case you're wondering.

In theory Velpatasvir should be better - It has an EC50 of 20 vs 530 for daclatasvir, but only about 25% gets absorbed so that robs it of part of the 26.5x theoretical edge, dropping it to say 7x, but then the dose is 100 mg vs 60 mg so that pushes it up to about 10x.

Now resistance comes in 10x, 100x and 1000x strengths so 10x is just enough to probably make a real difference for a few patients.

I have no doubt that 16 weeks SOF+DCV works better in GT3 patients than 12 weeks, so that is a factor.

Attachments:

...ort.pdf (4,214KB)

YMMV

Last Edit: 1 month 4 weeks ago by James-Freeman-facebook.

The administrator has disabled public write access.

The following user(s) said Thank You: rohcvfighter

Genotype 3's info, updates corner 1 month 2 weeks ago #24639

gypsy Offline Senior Member Posts: 55 Thank you received: 87 Karma: 1	I am genotype 3A and have been generic epclusa only a little over a week. My fibroscan looked normal. The first few days I felt kind of off but take it at night now and am noticing improvement in energy off and on.
	The administrator has disabled public write access. The following user(s) said Thank You: Paul-Jarman-facebook, Mnem