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HCV New Drugs Blogspot 7 years 1 month ago #11459

  • mgalbrai
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From the weekend:

hepatitiscnewdrugs.blogspot.com/2016/02/...hepatitis-c-bbc.html

hepatitiscnewdrugs.blogspot.com/2016/02/...ver-hepatitis-c.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: pat1

HCV New Drugs Blogspot 7 years 1 month ago #11547

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New Screening and treatment criteria from WHO:

hepatitiscnewdrugs.blogspot.com/2016/02/...-in-updated-who.html


Thousands recalled for hepatitis C test after NHS worker's diagnosis:
hepatitiscnewdrugs.blogspot.com/2016/02/...epatitis-c-test.html


Bristol-Myers Squibb (NYSE:BMY) Presents Data on All-Oral Hepatitis C Regimen:
hepatitiscnewdrugs.blogspot.com/2016/02/...ysebmy-presents.html
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: pat1, darbara

HCV New Drugs Blogspot 7 years 1 month ago #11566

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That last article is curious considering BMS withdrew application for approval of asuneprevir (in combination with daclatavir) in Oct 2014 Because -

In clinical trials, BMS’s combination, on the other hand, cured just 82 percent to 90 percent of those with genotype 1b after 24 weeks.

Source - www.hepmag.com/article/asunaprevir-end-26284-925493039

I wonder what changed, as they are reporting higher SVR rates in this trial?
M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia

HCV New Drugs Blogspot 7 years 1 month ago #11662

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Re Cirrhosis:
2/24/16

hepatitiscnewdrugs.blogspot.com/2016/02/...gy-therapeutics.html


Re Zepatier:

hepatitiscnewdrugs.blogspot.com/2016/02/...tier-vs-harvoni.html
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 1 month ago #11677

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sonix wrote: That last article is curious considering BMS withdrew application for approval of asuneprevir (in combination with daclatavir) in Oct 2014 Because -

In clinical trials, BMS’s combination, on the other hand, cured just 82 percent to 90 percent of those with genotype 1b after 24 weeks.

Source - www.hepmag.com/article/asunaprevir-end-26284-925493039

I wonder what changed, as they are reporting higher SVR rates in this trial?


Looks like the 2014 report relates to earlier trials for approval for use in US so probably consisted mostly of western patient profile whereas these latest late stage trial results are for an all Chinese patient profile. This differing result is possibly to be expected as various racial groupings show differing responses to the old interferon treatments and also susceptibility to fibrosis/cirrhosis.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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HCV New Drugs Blogspot 7 years 1 month ago #11805

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Lots of good reading here:

Indian Patent Challenge:

hepatitiscnewdrugs.blogspot.com/2016/02/...enge-hearing-on.html

ABBVIE RECEIVES CHMP POSITIVE OPINION FOR VIEKIRAX® (OMBITASVIR/PARITAPREVIR/RITONAVIR TABLETS) + EXVIERA® (DASABUVIR TABLETS) WITHOUT RIBAVIRIN FOR THE TREATMENT OF CHRONIC HEPATITIS C IN GENOTYPE 1B:

hepatitiscnewdrugs.blogspot.com/2016/02/...ositive-opinion.html

This version of the Guidance has been updated to reflect several important developments, including the recent approval of elbasvir/grazoprevir:

hepatitiscnewdrugs.blogspot.com/2016/02/...ir-hcv-guidance.html

Why Americans pay so much more for drugs:

hepatitiscnewdrugs.blogspot.com/2016/02/...-more-for-drugs.html


Quoted from the above article. Steve Miller, chief medical officer of Express Scripts wrote:

"The U.S. is 4.6 percent of the world's population, we're 32 percent of the world's drug revenue, and we're somewhere between 50 and 70 percent of world drug profitability," Miller said. "The United States has been spending money to protect the world for decades. We're now being asked to essentially fund all pharmaceutical drug development. ... We cannot continue to carry this burden."
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: zhuk

HCV New Drugs Blogspot 7 years 1 month ago #12033

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Interesting...

hepatitiscnewdrugs.blogspot.com/2016/02/...000-pill-for-10.html

RE; Australia:

hepatitiscnewdrugs.blogspot.com/2016/02/...now-as-cheap-as.html

Lack of awareness, affordability, etc.

hepatitiscnewdrugs.blogspot.com/2016/02/...-affordable-but.html
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G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 3 weeks ago #12331

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Friday 3/4/2016

hepatitiscnewdrugs.blogspot.com/2016/03/...ugs-now-covered.html

hepatitiscnewdrugs.blogspot.com/2016/03/...-general-probes.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 3 weeks ago #12502

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The"Buyers' Club Era" article, among others:

hepatitiscnewdrugs.blogspot.com/2016/03/...s-with-news.html?m=1
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: pat1

HCV New Drugs Blogspot 7 years 3 weeks ago #12570

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Recommendations from John W. Ward, MD, director of the Division of Viral Hepatitis at the Centers for Disease Control and Prevention (CDC).:

hepatitiscnewdrugs.blogspot.com/2016/03/...re-out-of-reach.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
The following user(s) said Thank You: pat1

HCV New Drugs Blogspot 7 years 2 weeks ago #12672

  • mgalbrai
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From the CDC:
Annual Report to the Nation: Cancer death rates continue to decline

Increase in liver cancer deaths cause for concern

hepatitiscnewdrugs.blogspot.com/2016/03/...ne-but-increase.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 2 weeks ago #12812

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Merck vs Gilead:
hepatitiscnewdrugs.blogspot.com/2016/03/...tis-c-drugs.html?m=1

Insurers rail against exorbitant drug costs:
hepatitiscnewdrugs.blogspot.com/2016/03/...t-high-cost.html?m=1
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 1 week ago #13055

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Some good reading here in "HCV Next"

hepatitiscnewdrugs.blogspot.com/2016/03/...g-gap-impact-of.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 1 week ago #13145

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3/18/16

hepatitiscnewdrugs.blogspot.com/2016/03/...-and-recruiting.html
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24

HCV New Drugs Blogspot 7 years 1 week ago #13353

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Why U.S. prices will stay high:

hepatitiscnewdrugs.blogspot.com/2016/03/...ent-lowered.html?m=1
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forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
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