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TOPIC: Is there any evidence of DAAs impacting kidney function?

Is there any evidence of DAAs impacting kidney function? 2 years 2 months ago #18181

  • beaches
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Just wondering this because at EOT my Estimated Glomerular Filtration Rate has dropped to 71.

On 18 March the day before starting Tx, it was 87 which is just below normal range.

At week 4 it was >90

Should I be worried? :ohmy: :unsure:
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Is there any evidence of DAAs impacting kidney function? 2 years 2 months ago #18196

  • Price
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Because the calculation works best for estimating reduced kidney function, the National Kidney Foundation suggests only reporting actual results once values are < 60 mL/min (they state normal values as 90-120 mL/min). An eGFR below 60 mL/min suggests that some kidney damage has occurred.

So 60 is the number to watch for.

We had someone in our group end up on dialysis after Harvoni BUT he started with a GFR below 60. He probably would have ended on dialysis anyway.

P
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Is there any evidence of DAAs impacting kidney function? 2 years 1 month ago #18197

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Thanks Price. I guess I'll have a look at the reading in 3 months when I get tested for SVR12.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Is there any evidence of DAAs impacting kidney function? 2 years 1 month ago #18218

  • DrJames
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Hi Beaches,

This is something to watch rather than panic about. Creatinine is an indirect measure of kidney function and eGFR is calculated using a formula from this.

A good first step would be the have a urine dipstick - you should have not protein or red cells in this - if you do that needs looking into further.
YMMV
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Is there any evidence of DAAs impacting kidney function? 2 years 1 month ago #18220

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Hope you are not calling me a dipstick, Doc :silly:
Thanks for the advice. My creatinine level was 78 which is in he normal range (I believe - well Dr Google tells me so).
I'll follow up the urine dipstick suggestion, thanks very much for your advice.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
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Is there any evidence of DAAs impacting kidney function? 2 years 1 month ago #18391

  • beaches
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Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
The administrator has disabled public write access.

Is there any evidence of DAAs impacting kidney function 2 years 1 month ago #18396

  • Gaj
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My chemistry is a little rusty but I suspect you will end up with gas, water and salt in your stomach. ;)

depts.washington.edu/chem/facilserv/lect...ept.ofChemistry.html

I'll leave it to the medical types to comment on any benefits to the kidneys.
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:
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