Re-treating with Vosevi

[Songbird]

Hi
New here and will tell my story to date.
Was in a trial in 2010 at the very beginning of DAA trials.
Am a GT 1a and did trial of
Daclatasvir/peg/riba. As we have come to learn 8 yrs. later this was sup-optimal and I relapsed.
Unfortunately, ended up with quite a nasty Ns5a linked resistant mutation of H58d/Q30r
I am being tx. By Doc Feld(whom I have seen mentioned here) from CCO articles.
We waited until now for triple(vosevi) because of said resistance profile.
I am treating aggressively for 16 Wks(instead of the 12) and he added Riba from get go.
I am at week 7. VL at wk. 4 was Llod 15 and will test again at Wk 8.
After 41 yrs. infected fortunately still f2, however really want to get rid of this

Just posted this in case anyone else on vosevi or mav and wanted to weigh in.
Will keep updating
Sheila

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Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[Dr James]

Hello Shiela,

You are in very good hands. Professor Jordan Feld is one of the world experts in HCV treatment.

Good luck. It looks like things are already heading the right way.

---

YMMV

[Songbird]

Thank you for the good luck wishes Dr. James.
Yes, I feel very fortunate to be under the care of Dr. Feld.

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[Ariel]

Hi there Sheila aka Songbird
I love the name! Fantastic song takes me back to the era where all the fellas were in lust with Stevie Nicks, though that of course was Christine McVie.
Wishing you all the best during your tx, sending you good vibes flippers and fins crossed that this nasty knicks off for good for you Songbird.
Lots of Happies to you from Ariel

[fretboard]

Hi Songbird,
I hope you’re doing well on your vosevi and riba! I hate hearing about mutations, it just adds to the hideousness of HepC and for you to find out 8 years later, my heart goes out to you!! I feel for you and I truly hope all goes well this time, so you will finally be cured! Good luck and I hope you have an easy walk through tx with the vosevi and riba!! ~Cheers!!

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G1a dx’d in 1992, Biopsy F2 VL 8mill +. Tried tx with Interferon/Riba, back in 2008 didn’t last long it felt horribly ugly!! I stopped tx, after 5 weeks!!
Started tx 6/1/16 with Harvoni.
12 Month Labs= UND

[Songbird]

Thank you very much Ariel & fretboard for your good wishes.

Very much appreciated.

S

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[coral]

Hi Songbird,

Wishing you well after such a wait for the right treatment.

I was lucky that my treatment was post the peg era but I did have a lengthy treatment regime due to a relapse. I had the Viekira pak, sof and ribavirin the second time around. The riba gave me a few more side effects but well worth it for the successful outcome.

I look forward to reading your updates.

Coral

[Songbird]

Hi coral,

Thank you for the well wishes!

I see from your profile that yes you sure did an extended treatment and somewhat outside the box .

Congrats on Finally achieving SVR !! Well done!

Finally typed in my profile here and will keep updating.

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[Songbird]

Got my Wk 8 VL result..UND!

Great to see that word again.

Staying hopeful

S

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[Dr James]

Great news songbird. It is a stepping stone to SVR

---

YMMV

[Ariel]

Hi Songbird
Wonderful milestone
Nearly there!
Sending goodvibes for the last part of tx
Happy Splashes from Ariel

[Songbird]

A shout out THANK YOU to DR.Freeman who has been extremely helpful advising me on obtaining the equivalent drug regime I need for week 12-16 .

S

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[Songbird]

Sorry Doctor Freeman, In my excitement my spelling went wonky

S

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

[coral]

Great news Songbird. Only a few more weeks to go…..

[Songbird]

Just finishing 12 weeks of Vosevi(Wed.11th). VL : Und.

Starting 4 weeks of Qurevo(Partaprivir/ritonivir/Ombitasvir) Plus Sof/Riba.

Feeling good and remaining hopeful.

S

---

Diagnosed: 2001 GT1a , HCV since mid-70’s.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!

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