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TOPIC: 2B HERE

2B HERE 6 years 4 months ago #6587

flyingfox66 Offline Elite Member Posts: 172 Thank you received: 214 Karma: 0	God sake if it really is a cost cutting measure its an incredibly petty and nasty one! I can't help thinking anyone with a speck of human compassion would want to chuck the Interferon on the incinerator asap. Perhaps the people who make these decisions just never get to see what happens at ground zero? It's the only way I can imagine they aren't monsters.
	F49HepC25ysGT1a "mild" Harvoni 12 wks Brisbane, Australia The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6662

2b
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Hi Joy, aaaaaaaaa, that's just the same old tired mantra that the US FDA uses for GT 2's. Europe I believe years ago figured out you can cure GT 2's with sofosbuvir and daclatasvir without ribavirin.

I have read that the only reason this persists as the "approved" treatment for GT 2's is that there are so few of us (relative to the other genotypes) that none of the big outfits have decided it was worthwhile to invest the money to test out the efficacy of dac and sof on GT2s, so the ribavirin recommendations remain just because of cheapness and the lack of investment in trials on GT 2's.

Unless there is some aggravating condition , like cirrhosis or something, I believe GT2s can do fine without ribavirin. I am, I was clear at 4 weeks without it.

GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!"

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2B HERE 6 years 4 months ago #6678

zhuk Offline Platinum Member Posts: 551 Thank you received: 502 Karma: 3	Nice to see you over at hepmag as comrade-in-arms to Coach Mike, 2b (at least I'm pretty sure its you Lol)
	GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6679

Joan
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My thoughts on GT2's getting around Ribavirin.

Go to a very supportive GP.

Explain the difference between Ribavirin and Daclastivir and how the body responds and the side effects.

Explain that there are GT2's who have and are responding to Sof/Dac and at 4 weeks have responded UND.

Insist that you get a script of Sof/Dac and that you have done your research and if they are in doubt ask them to look at FixHepC website and look at the facts around treatment for GT2's on Sof/Dac.

GT2B Diagnosed 1989
Started Tx 6.Nov.2015
F3 Fibroscan 17: April.2015
Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015

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2B HERE 6 years 4 months ago #6700

2b Offline Platinum Member Posts: 350 Thank you received: 495 Karma: 1	Aye Mate, it is me, 2B, over there, guarding the flank!
	GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!" The administrator has disabled public write access. The following user(s) said Thank You: Gaj

2B HERE 6 years 4 months ago #6710

zhuk Offline Platinum Member Posts: 551 Thank you received: 502 Karma: 3	Glad to hear it, Comrade! Hey at least you won't need the claymores left over from the delphi forums skirmish
	GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 The administrator has disabled public write access. The following user(s) said Thank You: Gaj

2B HERE 6 years 4 months ago #6764

2b Offline Platinum Member Posts: 350 Thank you received: 495 Karma: 1	Oh I'm still maintaining surveillance over those flat-earth holy rollers--if I see them start misleading people again like they were, I'll have to assume a new identity and dig up the munitions and wade back in there. They seem to have calmed down for the time being, haven't seen any anti-generic rants on there for awhile now, but I'll keep an eye on em.
	GT 2b; since 80's, no prior tx, sofosbuvir and daclatasvir compounded from API's at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. " I feel GOOD!! I knew that I WOULD!" Last Edit: 6 years 4 months ago by 2b. The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6925

Joan Offline Senior Member Posts: 71 Thank you received: 95 Karma: 1	Hello G2's Just to clarify I made a few enquiries at the clinic regarding my Genotype and I am GT2b also my viral load was Undetected which I assumed was 0. So thats clear. The finer details of this language is fairly new to me and I am learning as I go via this forum. Also recently learnt how to do my signature. Still trying towok out the smilies. Thanks to all of you
	GT2B Diagnosed 1989 Started Tx 6.Nov.2015 F3 Fibroscan 17: April.2015 Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015 Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015 The administrator has disabled public write access. The following user(s) said Thank You: Joy, Lynne-Francis-facebook, zhuk, Jaz

2B HERE 6 years 4 months ago #6927

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	Congratulations on your UNdetected, Joan! That must be a great feeling. (Just click or tap the smilie you want from the group above the box where you type the message)
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6930

IRMA88 Offline Senior Member THEY FIXED ME HERE!!! Posts: 41 Thank you received: 53 Karma: 0	Congratulations Joan! Great news
	G2B - DIAGNOSED 2014, STARTED SOF/DAC 11/11/15 VL 6M UND @ WEEK4 FINISHED TREATMENT 26/4/16 UND @ WEEK 24 ALT 12 AST 15 MY ETERNAL GRATITUDE TO GREG JEFFERYS & DR FREEMAN The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6971

zhuk Offline Platinum Member Posts: 551 Thank you received: 502 Karma: 3	Fantastic news, Joan! Great to hear, congratulations
	GT1a since 1988, diagnosed 1990 F0, tx naive VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9 Started Mesochem sof/dac 12 weeks 01/01/2016 11/02/2016 - 6 weeks UNDETECTED AST 26 ALT 26 The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6976

Jaz Offline Premium Member Posts: 83 Thank you received: 82 Karma: 0	Congratulations Joan! Excellent news!
	3a F0 TX Naive Started Tx 12/12/2015 Kingswood Sof/Dac Pre Tx - ALT 71 AST 40 V/L 9 million Day 11 - ALT 12 AST 15 4 week - LFTs normal - detected (same sample sent for v/l showed undetected) :/ 6 week - UND 12 week EOT - UND SVR4 SVR12 The administrator has disabled public write access.

2B HERE 6 years 4 months ago #6979

Joy Offline Elite Member Posts: 218 Thank you received: 265 Karma: 0	Yes really fantastic news Joan! smile smile smile smile smile smile smile smile smile smile smile smile smile smile smile I still haven't learned how to line up the smilies.
	NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive. Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct. Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. A thousand thankyous to Dr James and the amazing FixHepC team. The administrator has disabled public write access.

2B HERE 6 years 3 months ago #11261

LLJ Offline New Member Posts: 6 Thank you received: 2 Karma: 0	Hi, I just joined this board today. I'm another 2b, and am Fibrosure Stage 4. I'm in the US and am treating with 16 weeks of sovosbuvir and Ribavirin x16 weeks (16 because of fibro score). We are pretty uncommon here, too. I tell people that I have the posh European genotype because I got it when I lived in Great Britain.
	LLJ Geno 2b; Fibrosure 4. Tx: sovosbuvir/ribavirin x 16 weeks. EOT March 4, 2016 0 weeks: RNA = 10012000 iu/ml; log10 = 7.001. AST 129; ALT 133 4 weeks: PCR Quantitation = 60 iu/ml; log10 = 1.778. 5 weeks: PCR Quantitation < 15 (UND); AST 35; ALT 24 The administrator has disabled public write access. The following user(s) said Thank You: Tommy

2B HERE 6 years 2 months ago #11281

splitdog
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I would think about adding Daclatasvir to that. Couldn't hurt, that's for sure.

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Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James

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