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TOPIC: G1a relapse

G1a relapse 5 years 9 months ago #19941

coral
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Unfortunately my SVR11 results are back and they are not good (see below). This was my first blood test since the one I had done at 12 weeks of treatment (which was UND) although I continued my treatment to 24 weeks because of a slower response. I was going to wait until SVR 12 but went a week earlier because I suspected something wasn't right. How well we know ourselves now.

So the 12 weeks of Sof/Led followed by the 12 weeks of Sof/Dac wasn't enough to get rid of my tough critters.

I am allowing myself today to feel devastated but tomorrow I'll take a deep breath and in a very loud voice say NEXT!!!

VL 1950000
AST 93 (up from 24)
ALT 138 (up from 19)

I've told you before I've told anyone else - thanks for being there.

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...

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G1a relapse 5 years 9 months ago #19942

beaches
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The life you save will be your own. START TREATMENT
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O mate that sucks, so sorry to hear. We are living in good times for permanent resolution of HCV though, so I'm sure you have many options. Best wishes for permanently awesome health

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby

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G1a relapse 5 years 9 months ago #19943

fretboard Offline Elite Member Defender-Against Big Pharma! Posts: 175 Thank you received: 340 Karma: 3	That's a shame, sorry to hear it!
	G1a dx'd in 1992, Biopsy F2 VL 8mill +. Tried tx with Interferon/Riba, back in 2008 didn't last long it felt horribly ugly!! I stopped tx, after 5 weeks!! Started tx 6/1/16 with Harvoni. 12 Month Labs= UND The administrator has disabled public write access. The following user(s) said Thank You: coral, Matt-Kenney-google, Meg

G1a relapse 5 years 9 months ago #19944

Gaj Offline Moderator Optimist :-) Posts: 1436 Thank you received: 3082 Karma: 32	Coral, I'm so sorry to hear the news that your recent treatment has failed you. As beaches says there are a number of new and promising doors opening. (Pm sent)
	G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND The administrator has disabled public write access. The following user(s) said Thank You: coral, Matt-Kenney-google, Meg, fitz, Sven

G1a relapse 5 years 9 months ago #19945

coral
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Thanks Beaches, Fretboard and Gaj (and thanks so much for the PM Gaj). You are so right that there are good options already here or coming along soon. The fight goes on....

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...

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G1a relapse 5 years 9 months ago #19946

Hazel Offline Platinum Member Posts: 414 Thank you received: 1699 Karma: 39	So sorry to hear your news Coral, really unlucky. Those are tough critters all right to withstand you giving it 12 weeks of each. Best wishes for next stage.
	Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716 The administrator has disabled public write access. The following user(s) said Thank You: coral, Matt-Kenney-google, Meg, fitz

G1a relapse 5 years 9 months ago #19947

coral
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Thanks Hazel. Yes I think mine are terminator tough so I'll have to find something clever to fight them with.

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...

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G1a relapse 5 years 9 months ago #19948

LondonGirl
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Dear Coral, I am so sorry to read this

There are new options on the horizon, yes, allow yourself some time to recover from this and then back to fight mode.

Big

from across the seas.

LG

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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G1a relapse 5 years 9 months ago #19950

fitz
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Cured with generic DAAs. Hep C kills. Treat now!
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Coral, what a gut punch. Hurting for you.... Thankfully, you are here where you have the best team and options in the world. Thank God for that.

Know we will stand with you in fighting this beast. We will always be here for you, and with you - until the dragon is beaten and gone.

Failed Interferon 96', G1a, VL = 9 - 5.5 Million, F3/A3, AST 111, ALT 190, Generic DAA treatment Sof/Led (Mylan - India MYHEP LVIR) - 8 June, 2016
2 Week Results 20 June, 2016 AST 19, ALT 32
4 Week Results 06 July, 2016 AST 22, ALT 30, VL = 35
6 Week Results 20, July 2016 VL only = HCV RNA Detected, Non-Quantifiable <15
8 Week Results 04 August 2016, Labs, LFTs Normal, VL = UND
12 Week Results 31 August, 2016 LFTs Normal, VL = UND
EOT + 4 Weeks, LFTs Normal, VL = UND, "SVR4"
SVR12, 21 Nov 2016. CURED!!!

Last Edit: 5 years 9 months ago by fitz.

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G1a relapse 5 years 9 months ago #19951

tweakmax Offline Elite Member Posts: 256 Thank you received: 301 Karma: 2	LondonGirl wrote: Dear Coral, I am so sorry to read this There are new options on the horizon, yes, allow yourself some time to recover from this and then back to fight mode. Big from across the seas. LG LG Were u on triple therapy for the last four weeks?
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G1a relapse 5 years 9 months ago #19952

coral
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Thanks for your thoughts LG. On Friday I'm attending the funeral of someone who has died too soon with Hep C but thankfully not because of it. I think that's life putting things into pespective for me.

Hope all is going well for you over there.

G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...

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G1a relapse 5 years 9 months ago #19953

tweakmax Offline Elite Member Posts: 256 Thank you received: 301 Karma: 2	Coral Velpatasvir is coming soon. Stay calm
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G1a relapse 5 years 9 months ago #19955

poodle Offline Premium Member Posts: 109 Thank you received: 188 Karma: 2	Hi Coral so sorry to read this, very upsetting, not fair ,wish It was all good, but treatments are changing and very fast. Hang in , lean into the wind, it will come. Best Wishes Jill
	Geno1a 35years fibrosis 2 or 3 different results from different hospitals ?? 24weeks mesochem sof/led as unsure of fibrosis status. currently UND. No bad side effects Have svr12 ... waiting for svr 24 I now have SVR 36 weeks. The administrator has disabled public write access. The following user(s) said Thank You: coral, Gaj, Meg, fitz

G1a relapse 5 years 9 months ago #19956

Sven
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Coral - as I was assured I'll assure you. You are in the best place, there are brand new treatments here now you and can access them ASAP. You will slay this dragon and we will all be here to support you, to hold your hand and reassure you and continually tell you that your with the right and best people in the world.

Contracted HCV 1980's
Geno Type 1a
F3 ( doc says once treated I'll be F2 maybe F1)
Meds shipped 6/17/2016 arrived early 7/2016

Viral count - 3,471,080

4 week quantitative bloods: August 17, 2016. I have been diagnosed as <15 (told undetected)

8 week quantitative bloods: September 14th. I have been diagnosed as <15 (told undetected)

11 week PCR RNA Qualitative bloods: September 26th 2016 - Undetected

December 19th 2016: Cured!
Viral count: zero!!!
2018 viral count: still zero!
Cured!

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G1a relapse 5 years 9 months ago #19957

LondonGirl
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Hi TM, Yes, I was, just the last 4 weeks, well, actually, the last 2 weeks and then 2 weeks plus. Thinking maybe I should've done longer, I had a similar response to Coral, but I felt then 26 weeks in total was long enough.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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