- This topic has 16 replies, 9 voices, and was last updated 7 years, 9 months ago by
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Moved to the other post on topic
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Interesting but it looks to me that the level of deaths reported were less than 0.1% and given that a lot of Hep C patients would have been cirrhotic and elderly those deaths could have been caused by anything. Attributing them to the Hep C meds is a stretch IMHO.
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated
GT 3 – about 28 yrs with HCV
Is anyone talking about this?
https://www.nytimes.com/2017/01/24/health/hepatitis-c-antiviral-drug-study.html?_r=0
As the authors of the review note (please see attached PDF) there are many unanswered questions, however, liver failure and reactivation of Hep B (in those previously afflicted) are not minor issues. Although the review does not address the new pangenotypic daa’s (Beacon’s Sofosvel, Incepta’s Panovir, etc…
the data is clearly referencing the sofosbuvir backbone meds.
In light of recognizing these issues it would seem that simple before and after lab tests (pre and post 12 or 24 week tx) might not be sufficient. For patients moving forward with treatment it might be wise to add several points of lab testing (cbc, hep b panel, iron studies, liver fxn tests, etc..) DURING treatment course. This might allow any potential adverse effects to be caught before they are fully manifested.Moved post to the appropriate thread. Please start at the top.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
As noted by others the numbers of adverse events reported in the review is relatively small in comparison to both those treated and the potential risk of non treatment. As such the level of testing before and after treatment should be appropriate to the risk factors for the individual patient and I would be surprised if monitoring doctors did not include CBC, LFT, etc during treatment.
Edit: Some further reading about this report provides additional perspective and the following comments.
Douglas Dieterich, MD, director of the Institute for Liver Medicine at the Mount Sinai Health System in New York City, downplayed the significance of the report and said the findings should not change physician practice.
“The data in this report do not conclusively prove the hepatitis C medications Sovaldi and Harvoni cause liver failure. Without clear evidence of cause and effect, we cannot risk this information deterring patients from seeking the care they need,” he said in a prepared statement…..
……Even if the drugs caused the liver failure — and this report doesn’t prove that — the rate “is likely much lower than that of the liver disease itself,” he said. “We don’t know how many of these patients were cirrhotics but even healthy cirrhotics have a 10% per year mortality rate. For decompensated, it’s more like 30%.”
http://www.medscape.com/viewarticle/875010?src=wnl_edit_tpal&uac=250627FN
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sven,
I think your suspicions about their motives are probably ‘right on the money’, particularly assuming they can’t point to well conducted studies that back up their claims.
Regarding supplements, IMHO for most of us a well varied, balanced diet should provide most or all of our needs so ensuring we eat well is part of taking control of our health. However age, general health and liver condition may slightly impact our ability to absorb everything we require so when I started treatment I tested for vitamin deficiencies. Vit D was very low even though I get a fair bit of sun and B12 moderately low so I took supplements at the levels recommended for me, by my doctor, to boost both of them. So I used evidenced based data to determine whether I needed “extra” over and above my diet.
– Milk Thistle is claimed to reduce inflammation although the jury is still out. In moderate doses I doubt it will cause any harm but we know that SVR reduces inflammation anyway.
– Selenium is needed at trace levels, a couple of Brazil nuts a day or a tuna/beef steak every few days should do the trick.
– Magnesium can be found in fish, nuts, leafy greens, bananas and plenty of other foods.
– Blueberries are delicious! I usually sprinkle a few on my muesli/oats for breakfast as one of the fruits I add. Like many berries and other fruit they have good levels of antioxidants plus vitamins, etc, etc. I doubt they are ‘magic’, just a useful and tasty part of a well balanced diet. “a liver formula that helps remove inflammation”
Okay, this is where we are moving into uncharted territory and I would be very cautious. What does this formula contain? All the ingredients? Is there anything in there that could potentially be toxic to the liver? Or other organs? Who makes it? What are their facilities and qualitiy processes? How do they ensure there are no contaminants? Where are the documented studies that show that this formula has some positive effect on liver inflammation?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
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