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Please help.
I have been offered 12 weeks Sof/Riba and I am wondering why they have not used daclatasvir?
I cannot work out how to use the cheat sheet.
What is ELF? APRI?
What is Harvoni CI?I am attaching my blood results. Sorry the quality is rubbish.
My Fibroscan is 6.1. I am G2.
I have done 2 failed Peg/Riba treatments.TC.
Hi TC,
In many health systems Sofosbuvir/riba is considered a reasonably effective treatment for G2 and is the only approved DAA treatment. It is also a lot cheaper to prescribe so allows more people to be treated. So a difficult decision for health authorities.
I think if I was a G2 being offered that prescription and I had the opportunity to replace the Riba at reasonable cost to myself then I would investigate getting medical advice and a prescription for the Dac. This would apply even more so if I had failed peg/Riba previously.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi splitdog,
I’m not a doctor but in my opinion:
The database on trials for G2 is limited and based on that both Sof/dac and Sof/Riba have fairly similar outcomes for Tx experienced patients. I’d like to think with more data we will see Sof/Daclatasvir pull ahead but that may just be me.
On the other hand, even as someone who handles Riba really well, I personally would still far prefer to not have it in my treatment if possible. It does have quite strong side effects particularly if you are one of the people who get serious anaemia from it. It also has a much longer half life and takes many months to clear from your system at EOT.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi T120girl,
Fully awake now! (Coffee is good!
)Okay, you are trying to use the decision support calculator. ELF/APRI are blood tests for fibrosis. Ignore them and put in your 6.1 fibroscan result.
Harvoni CI is Contra-Indication i.e. one of the drugs listed or similar. You won’t use Harvoni b/c of genotype so just tick as no.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
It’s good to hear that some hospitals in the UK are becoming more supportive of generics. I suspect you will have difficulty getting the NHS script altered from what others over there have said. Scrips for generics should be arrangeable via tele-consultation if other options aren’t available and maybe there is some way to make up the difference over what you are being offered using generics?
The other option is to go totally generic which will cost a bit more and there are a number of options such as the Redemption trials or self import from a trusted supplier that we could suggest but I’m hoping one of our UK members can offer better guidance of what you need to do in either case?
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
So I put in the data and this is what came out.
HCVDecisionSupport.pdfI’m even more confused now.
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