Emilio's Place - FixHepC

This topic has 328 replies, 51 voices, and was last updated 7 years, 7 months ago by coral.

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3 November 2015 at 2:16 pm #3254
emilio
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- Replies: 368
- Total: 381
- Guardian Angel
@emilio
LG she has adjusted well after some sides the first few days. Getting better as it.goes which is great.

So an 80_90 kg male could do 625mg sof and 135mg dac comfortably, i think? Em
3 November 2015 at 2:21 pm #3255
Alsdad
- Topics: 18
- Replies: 317
- Total: 335
- Guardian Angel
@alsdad
Might be an option for someone with a high level of fibrosis or cirrhosis. I know the higher doses were trialled, up to a week if I remember correctly. I’m 95kg (no comments please, I get enough from my wife!) and F0 fibrosis, and the standard dose is working fine for me.
3 November 2015 at 2:37 pm #3256
LondonGirl
- Topics: 16
- Replies: 1,348
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- Guardian Angel
@londongirl
‘some sides’ ? ‘a little flu-like’? good to know things are getting better for your friend.
Interesting though, dose adjustments, so is it not so much length of time as dose then?
does high dose over short time = low dose over longer time ?

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
3 November 2015 at 2:45 pm #3257
emilio
- Topics: 13
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- Guardian Angel
@emilio
Hi AD, weight, fibrosis or geno based, maybe? If specialists, GPs start tinkering with this they may punch out a few more.percentage points in revard to clearance rates? These drugs wont be around longn enough, in my opinikn. Theyr already looking at 1 shot experimentals that are getting the same clearances rates. Em
3 November 2015 at 5:12 pm #3266
zhuk
- Topics: 5
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- Total: 548
- Guardian Angel
@zhuk
Interesting question re weight and dosage, thanks for the feedback everybody. I’m 53kg and 5’7″ so in that lightweight category: talking with Dr Freeman yesterday he suggested a possible slight drop in dosage for daclatasvir at least until a bit of tolerance had been reached might be needed – of course eveyone’s individual mileage may vary when it comes to personal side effect response. Will have to judge it when the time comes

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
3 November 2015 at 6:41 pm #3269
LondonGirl
- Topics: 16
- Replies: 1,348
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- Guardian Angel
@londongirl
How do you make a ‘slight drop’ ? Saw a bit off the end of the tablet? !

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
3 November 2015 at 7:08 pm #3270
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
LondonGirl wrote:

How do you make a ‘slight drop’ ? Saw a bit off the end of the tablet? !

Maybe take the meds 28 hours apart at first .

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
4 November 2015 at 3:34 am #3281
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
That does seem like a very reasonable way to go about it, rather than trying to titrate the dose down Paul…which is gonna be an inexact science heh Cheers for the suggestion!

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
4 November 2015 at 8:40 am #3305
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
It’s just a suggestion that I would want to run past a doctor first though zhuk.

cheers

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
4 November 2015 at 8:48 am #3306
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Sure Paul, will do. I should have my first GP consult sometime tomorrow, I’ve only let her know about treatment in a brief phone message. Both of us have got a bit of time to get up to speed though…a lot to take in

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
12 November 2015 at 10:53 am #3717
emilio
- Topics: 13
- Replies: 368
- Total: 381
- Guardian Angel
@emilio
Hi everyome

On the road with limited communication in remote area. My 4 week RNA still detected under 15. No RVR for me, anyway ill give this fucker 24 weeks and see if it wants to stay around. Disappointed but confident of cure. Em
12 November 2015 at 10:57 am #3718
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
Bummer Emilio hopefully next time up it’s gone, we both might be chasing some Riba yet !

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
12 November 2015 at 12:19 pm #3725
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Only 4 weeks in Emilio, less than 15 good and apparently tests can often detect dead virus’

On another subject, you seem to be very busy? Hope you’re not overdoing things and getting enough rest / sleep?
Your liver would like that you know

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
12 November 2015 at 2:58 pm #3745
dointime
- Topics: 29
- Replies: 325
- Total: 354
- Guardian Angel
@dointime
Hi Em,

Here’s slides on resistance data.
http://www.clinicaloptions.com/Hepatitis/Treatment%20Updates/HCV%20Resistance%20Alert/CCO%20Slideset/HCV_Resistance_Slides.aspx

They show that for people who do have NS5A resistant variants, the 24 week tx is the one that does the job more or less 100%. The 12 weeks is good but not 100%. So just in case you have some of these fuckers that just don’t want to lie down and die, I think you are good with 24 weeks.

dt
12 November 2015 at 3:07 pm #3747
Life
- Topics: 2
- Replies: 172
- Total: 174
- Guardian Angel
@life
Indeed! Encouriging post!
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