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  • 3 November 2015 at 2:16 pm #3254
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    LG she has adjusted well after some sides the first few days. Getting better as it.goes which is great.

    So an 80_90 kg male could do 625mg sof and 135mg dac comfortably, i think? Em

    3 November 2015 at 2:21 pm #3255
    Avatar photoAlsdad
    • Guardian Angel
    • ★★★★★
    @alsdad

    Might be an option for someone with a high level of fibrosis or cirrhosis. I know the higher doses were trialled, up to a week if I remember correctly. I’m 95kg (no comments please, I get enough from my wife!) and F0 fibrosis, and the standard dose is working fine for me.

    3 November 2015 at 2:37 pm #3256
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    ‘some sides’ ? ‘a little flu-like’? ;-) good to know things are getting better for your friend.
    Interesting though, dose adjustments, so is it not so much length of time as dose then?
    does high dose over short time = low dose over longer time ?

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    3 November 2015 at 2:45 pm #3257
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    Hi AD, weight, fibrosis or geno based, maybe? If specialists, GPs start tinkering with this they may punch out a few more.percentage points in revard to clearance rates? These drugs wont be around longn enough, in my opinikn. Theyr already looking at 1 shot experimentals that are getting the same clearances rates. Em

    3 November 2015 at 5:12 pm #3266
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Interesting question re weight and dosage, thanks for the feedback everybody. I’m 53kg and 5’7″ so in that lightweight category: talking with Dr Freeman yesterday he suggested a possible slight drop in dosage for daclatasvir at least until a bit of tolerance had been reached might be needed – of course eveyone’s individual mileage may vary when it comes to personal side effect response. Will have to judge it when the time comes :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    3 November 2015 at 6:41 pm #3269
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    How do you make a ‘slight drop’ ? Saw a bit off the end of the tablet? !

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    3 November 2015 at 7:08 pm #3270
    Avatar photoPaul-Jarman-facebook
    • Guardian Angel
    • ★★★★★
    @paul-jarman-facebook
    LondonGirl wrote:

    How do you make a ‘slight drop’ ? Saw a bit off the end of the tablet? !

    Maybe take the meds 28 hours apart at first .

    Two time relapser.

    SVR 4 achieved 12/16 at last
    SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

    GT 3 – about 28 yrs with HCV

    4 November 2015 at 3:34 am #3281
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    That does seem like a very reasonable way to go about it, rather than trying to titrate the dose down Paul…which is gonna be an inexact science heh Cheers for the suggestion!

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    4 November 2015 at 8:40 am #3305
    Avatar photoPaul-Jarman-facebook
    • Guardian Angel
    • ★★★★★
    @paul-jarman-facebook

    It’s just a suggestion that I would want to run past a doctor first though zhuk.

    cheers

    Two time relapser.

    SVR 4 achieved 12/16 at last
    SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

    GT 3 – about 28 yrs with HCV

    4 November 2015 at 8:48 am #3306
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Sure Paul, will do. I should have my first GP consult sometime tomorrow, I’ve only let her know about treatment in a brief phone message. Both of us have got a bit of time to get up to speed though…a lot to take in :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    12 November 2015 at 10:53 am #3717
    Avatar photoemilio
    • Guardian Angel
    • ★★★★★
    @emilio

    Hi everyome

    On the road with limited communication in remote area. My 4 week RNA still detected under 15. No RVR for me, anyway ill give this fucker 24 weeks and see if it wants to stay around. Disappointed but confident of cure. Em

    12 November 2015 at 10:57 am #3718
    Avatar photoPaul-Jarman-facebook
    • Guardian Angel
    • ★★★★★
    @paul-jarman-facebook

    Bummer Emilio hopefully next time up it’s gone, we both might be chasing some Riba yet !

    Two time relapser.

    SVR 4 achieved 12/16 at last
    SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

    GT 3 – about 28 yrs with HCV

    12 November 2015 at 12:19 pm #3725
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Only 4 weeks in Emilio, less than 15 good and apparently tests can often detect dead virus’

    On another subject, you seem to be very busy? Hope you’re not overdoing things and getting enough rest / sleep?
    Your liver would like that you know :)

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    12 November 2015 at 2:58 pm #3745
    Avatar photodointime
    • Guardian Angel
    • ★★★★★
    @dointime

    Hi Em,

    Here’s slides on resistance data.
    http://www.clinicaloptions.com/Hepatitis/Treatment%20Updates/HCV%20Resistance%20Alert/CCO%20Slideset/HCV_Resistance_Slides.aspx

    They show that for people who do have NS5A resistant variants, the 24 week tx is the one that does the job more or less 100%. The 12 weeks is good but not 100%. So just in case you have some of these fuckers that just don’t want to lie down and die, I think you are good with 24 weeks.

    dt

    12 November 2015 at 3:07 pm #3747
    Avatar photoLife
    • Guardian Angel
    • ★★★★★
    @life

    Indeed! Encouriging post!

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