First Genotype 6 – Subtype 6a on this forum

[GT2]

Hi Dac

Good to hear that you are still UNDETECTED at 12 weeks.

I would be hesitant to drop the Rib considering the Hepcivir L + Rib combination is working so well.

I’m not a medical professional, so my opinion is merely a lay person using logic.

Sorry to hear about your dose of diarrhoea and the itchy rash. I would be seeking out remedies for those instead.

A discussion of remedies for rashes can be found here:
http://fixhepc.com/forum/end-of-treatment-eot/730-5-months-post-harvoni-horrible-rash.html?limitstart=0

http://fixhepc.com/forum/end-of-treatment-eot/669-lynne-s-end-of-treatment.html?start=15#14690

I’m sure others can suggest remedies for the diarrhoea.

Ribavirin has a long list of side effects, however, try to look at it as short-term pain for a long-term gain.

Cheers

GT2

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1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂

[Dr James]

With so little really known about GT6 (as in only 25 people reported taking it for 24/25) it’s really hard to take a view. If it ain’t broke don’t fix it but if it’s coming to a question of stopping the riba or stopping treatment stop the riba and continue on the generic Harvoni.

Trials Data For Genotype 6

Sofosbuvir PegIFN-α Ribavirin

NAIVE
default: svr: 100%, trials: NEUTRINO 100% GT6 (6/6)
w24: svr: 100%, trials: ATOMIC 100% GT6 (5/5)

Sofosbuvir Ledipasvir
NAIVE
default: svr: 96%, trials: NCT01826981 96% GT6 (24/25)

Sofosbuvir Daclatasvir
NAIVE
default: svr: 97%, trials: No Trials – Based on GT1 extrapolation

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YMMV

[dacngvn]

Thank you Dr Freeman.
Just met my hepatologist, she told me to continue taking Riba as my fibroscan is still f4 ? And have blood test at 16 weeks…

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GT-6a, diagnosed ’08, relapsed after 78 weeks Tx PEG/Riba -Fibroscan ’14 (F3/F4), Ultrasound with borderline cirrhosis without nodules, still compensated.
Post re-Tx: VL: 10,100,000 IU/ml – PLT:120 – GGT: 43.42 – AST: 67.80 – ALT: 63.32 – Fibroscan: F4.
Start Hepcivir L+Rib 24 weeks on April 2nd ’16.
Day 12: VL 567 IU/ml GGT 33 AST 32 ALT 30
Day 24: VL 29 IU/m GGT 28 AST 26 ALT 24
Day 56: VL UND GGT 27 AST 28 ALT 37
Day 84: VL UND GGT 30, AST 28, ALT 33, AFP 5.14

[GT2]

Hi Dac

Some tried and tested home remedies for diarrhoea include yoghurt with live probiotics, ginger, bananas and apple cider vinegar. Try some or all to see which ones help you.

Despite the side effects, being UNDETECTED at 12 weeks is something to celebrate.

Cheers

GT2

---

1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂

[Matt-Kenney-google]

Sounds like good advice dacngvn. And, oh yes, congratulations on12 week UNDETECTED!!!

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GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”

[dacngvn]

Thanks Matt, wish the best for you too

---

GT-6a, diagnosed ’08, relapsed after 78 weeks Tx PEG/Riba -Fibroscan ’14 (F3/F4), Ultrasound with borderline cirrhosis without nodules, still compensated.
Post re-Tx: VL: 10,100,000 IU/ml – PLT:120 – GGT: 43.42 – AST: 67.80 – ALT: 63.32 – Fibroscan: F4.
Start Hepcivir L+Rib 24 weeks on April 2nd ’16.
Day 12: VL 567 IU/ml GGT 33 AST 32 ALT 30
Day 24: VL 29 IU/m GGT 28 AST 26 ALT 24
Day 56: VL UND GGT 27 AST 28 ALT 37
Day 84: VL UND GGT 30, AST 28, ALT 33, AFP 5.14

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