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  • 22 August 2016 at 7:13 am #22435
    Avatar photocoral
    • Guardian Angel
    • ★★★★★
    @coral

    That’s great news GF. :) #flower #flower Let me add a “love your work” too. Next stop 24!!!

    22 August 2016 at 1:43 pm #22454
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    Twinvir and the people at Incepta-great….
    SVR for GF-priceless!!

    It makes me want to
    https://youtu.be/9G4jnaznUoQ

    Happy for you!!
    m

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    10 September 2016 at 4:16 am #22874
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    I found this online:

    http://www.hepmag.com/blog/hepatitis-c-treatment-svr

    More than 9 out of 10 people will be cured using the current treatments for chronic hepatitis C virus infection. It is thrilling to be told that hepatitis C is no longer detectable in your blood. However, as much as we yearn for those words, sometimes it takes a long time to believe that hepatitis C is gone forever.

    The medical term for a successful hepatitis C treatment outcome is sustained viral response (SVR). Undetectable HCV for 24 or more weeks after the end of treatment is an SVR24. Recently, many studies use the term SVR12, meaning that hepatitis C is undetectable for twelve or more weeks after the end of treatment. For those of us had a hard time believing that being viral-free for 24 weeks meant we were cured, then 12 weeks felt unbelievable. Can we trust this?

    For most of us, yes. In the January 2015 Hepatology, Eric Yoshida and colleagues reported that there wasn’t much difference between an SVR12 and SVR24 among hepatitis C patients who were treated with regimens using sofosbuvir. It didn’t matter if interferon was part of the regimen. Analyzing data from studies using sofosbuvir, researchers looked at response rates for genotypes 1 through 6. There were a total of 327 genotypes 1, 4, 5, 6 (mostly genotype 1); 294 genotype 2s; and 250 genotype 3s.

    Results

    Before presenting the results, there are a couple more terms that are important to understand:

    •Relapse was defined as having a negative hepatitis C viral load (HCV RNA) at the end of treatment and subsequently having detectable HCV RNA above the LLOQ.
    •In this case, LLOQ is lower limit of quantification, which is the lowest amount of virus that can be precisely counted.

    SVR24 was achieved in 777 of 779 patients (99.7%) with SVR12. This means that everyone but two people who achieved an SVR12 had an SVR24. Here’s the kicker: the two patients who didn’t achieve an SVR 24 both had genotype 3 (both non-cirrhotic, treatment-experienced). Therefore, if you discarded the data for genotype 3 patients and counted everyone else, 100% of those who had an SVR12 had an SVR24. Using viral sequencing, these cases were relapses and not reinfection.

    I am going for SVR 24 test, but it looks like I am cured! :woohoo: :+1: :+1:

    10 September 2016 at 4:39 am #22877
    Avatar photoAriel
    • Guardian Angel
    • ★★★★★
    @ariel

    Thanks GF for this good news I needed a happy today my mouth is so sore and I have my SVR24 this week
    Great positive post I am confident too :+1:
    Ariel #flower

    14 September 2016 at 7:51 am #22941
    Avatar photofitz
    • Guardian Angel
    • ★★★★★
    @fitz

    Fighting greed. Kicking ass!

    Buh bye Hep C, adios, aufwiedersehen…..

    14 October 2016 at 3:27 am #23811
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    SVR 24 Results – UNDETECTED!! :woohoo: :+1: :+1:

    14 October 2016 at 3:36 am #23813
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Love your work GF, congrats
    happypikachu.jpg

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    14 October 2016 at 4:33 am #23818
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    :woohoo: Congratulations GF! :cheer:

    #dance

    And thanks for all your work spreading the word. :+1:

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    14 October 2016 at 4:41 am #23819
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    Thanks Gaj! You are right behind me Brother! :cheer: :+1:

    14 October 2016 at 4:57 am #23821
    Avatar photoHieupham
    • Topics: 9
    • Replies: 50
    • Total: 59
    • Recovery Champion
    • ★★★★
    @hieupham

    Yayyy!
    Fantastic, GF!

    thumpsup.gif
    :+1: :+1: :+1:

    Nishkama Karma
    Cùng nhau loại bỏ Viêm gan C trên khắp thế giới!

    14 October 2016 at 5:13 am #23822
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    Thanks Hieupham!! :cheer:

    14 October 2016 at 9:41 am #23830
    Avatar photoCC2B
    • Guardian Angel
    • ★★★★★
    @cc2b

    Awesome news!!!! :woohoo:
    Congrats GF :+1:
    #flower #flower #flower

    GT2b diagnosed 10/2015
    since: unknown
    11/20/15 VL= 214,070
    12/4/15 ALT=18 AST= 24
    1/16/16 started sof/dac
    2/13/16 @4wks VL=UND ALT=13 AST=22
    3/12/16 @8wks VL=UND ALT=10 AST=18
    4/9/16 EOT VL=UND ALT=11 AST=19
    9/23/16 SVR24 ALT=11 AST=22

    14 October 2016 at 10:24 am #23834
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Great news GF – Delighted for you :cheer:
    Congratulations from me too :+1:

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    14 October 2016 at 1:14 pm #23836
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    Way to go Greed Buster!
    You da man!!
    m

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    14 October 2016 at 2:13 pm #23839
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    Thanks CC2B, LondonGirl and Mike!!

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