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11 May 2016 at 9:03 am #16957
Sorry to hear of your friend, it must be so difficult being stuck in that situation. While DAAs themselves are unlikely to reduce fibrosis on their own, there is considerable research and clinical trialling going on of other medications that do target fibrosis reduction in the liver and other areas. Some of the research and trials are quite advanced so hopefully we will get some good news soon.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515973/
https://www.monash.edu/__data/assets/pdf_file/0008/376838/Anti-fibrotic-drug-development.pdf
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
11 May 2016 at 9:15 am #16959Gaj,
I sort of quoted that part…
“We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation and that inactivation of CB1 exerts potent antifibrotic effects in inflammation-driven models of fibrosis.”http://www.ncbi.nlm.nih.gov/pubmed/20617520
His doctor said “interferon increases the adhesion of fibroblasts to fibronectin ” as the cause of Peyroni’s.
P.
11 May 2016 at 10:11 am #16960The “in inflammation-driven models of fibrosis” part of the original text is important to context.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
11 May 2016 at 6:31 pm #16967Wednesday 5/11/16
5 Things You Should Know About Dietary Supplements for Hepatitis C
http://hepatitiscnewdrugs.blogspot.com/2016/05/5-things-you-should-know-about-dietary.htmlAlcohol accelerates liver damage in people living with hepatitis C
http://hepatitiscnewdrugs.blogspot.com/2016/05/alcohol-accelerates-liver-damage-in.htmlJanssen to Start a Phase IIb Study/Combinations of Simeprevir, Odalasvir and AL-335 for the Treatment of Hepatitis C
http://hepatitiscnewdrugs.blogspot.com/2016/05/janssen-to-start-phase-iib-study-of.htmlPublic Reporting Measures Fail to Describe the True Safety of Hospitals
http://hepatitiscnewdrugs.blogspot.com/2016/05/public-reporting-measures-fail-to.html
Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtxG 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 2411 May 2016 at 11:52 pm #16973Thanks for posting.
That’s very interesting, but not the complete story imnsho.
Supplements may not fix your liver or reduce your VL but the virus impacts other things as well. Your liver, immune system, digestion etc are compromised and that’s where supplements can help.
Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or soEOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby16 May 2016 at 11:12 pm #17319The curious case of generic sofosbuvir:
http://hepatitiscnewdrugs.blogspot.com/2016/05/the-curious-case-of-generic-hep-c-drug.html?m=1
Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtxG 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 2416 May 2016 at 11:51 pm #17321Cheers Mike. I visited the comments section, left my piece
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
17 May 2016 at 6:19 pm #17354Concerning the high price of HCV treatment:
http://hepatitiscnewdrugs.blogspot.com/2016/05/the-cost-of-drugs-is-killing-us-how-can.html
Gilead Sciences’ patent on hepatitis C drug sofosbuvir challenged in Delhi High Court
http://hepatitiscnewdrugs.blogspot.com/2016/05/gilead-sciences-patent-on-hepatitis-c.html
Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtxG 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 2417 May 2016 at 7:29 pm #17356WOWZERZ Mike!
Concerning the high price of HCV treatment:The article was interesting, but the “comments” were incredible! I couldn’t keep up with a lot of it. Sure are a plethora of ideas out there heh.
Thanks for sending these posts along …
GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”17 May 2016 at 11:51 pm #17367I commented on the patent challenge story, will see if it makes it past moderator.
Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716
18 May 2016 at 2:16 am #17370Matt-Kenney-google wrote:WOWZERZ Mike!
Concerning the high price of HCV treatment:The article was interesting, but the “comments” were incredible! I couldn’t keep up with a lot of it. Sure are a plethora of ideas out there heh.
Thanks for sending these posts along …Matt yes these links are useful
I’m in the habit of emailing the ones most relevant to myself and I folder them as a resource for my lobbying
This corner of the forum has a lot of relevant info
I’m fussy about biases and dates and so also check who the author is of any links etc but that’s just me.
Mostly links are relevant and excellent education.
Cheers and yes I agree ty Mile again for the research
ArielPS Hazel your comment is there xxx I read it ty
18 May 2016 at 2:51 am #17373Hi Ariel,
I love most all of the posts here and throughout the forums. Very educational and helpful As an example your sharing the fact that you’ve made an email folder for personal use and to share with those who may not be as up to date on what’s going on around them …
Great idea. I’m stealing it
GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”18 May 2016 at 3:17 am #17375The comments posted on that site are useless!
I posted some info about TPP recently. It looks like “they” are going to ignore/suppress info concerning generics. Gilead has a patent! In the 1st world countries, the health systems will not embrace generics for 20 years! They can’t, we have patent laws. All these people pissing and moaning about greedy pharma, while valid, accomplish nothing! It is the clandestine access to generics that is real – why we are all here. Push this site, the Redemption trials or Incepta and their hepatitisctreatment@gmail.com email. As Dr. Freeman has stated, time may be short for access. The mainstream access will be decided by TPP. TPP is a done deal folks. It’s going to happen. My insurance company (Blue Cross/Blue Shield of Florida) was hoping I would die before they had to give me treatment! They wanted me to wait until I was on the transplant waiting list (F4) Incepta is who helped me! Anyone wanting treatment has to spend their own money and get treatment. $1000 for a cure seems reasonable to me.
18 May 2016 at 3:46 am #17377That’s freedom of the press for you eh GF . Well said, on getting treatment you need, where you can, at a price that makes some sense
GT1a; Got it some time in the 70’s; Diagnosed @1976
Tx naive
METAVIR: A2-F2
SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
3 weeks after SOT: AST 27 ALT 31 VL 138
Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
Hep C RNA NOT DETECTED”18 May 2016 at 3:50 am #17378Matt-Kenney did you get your meds? What make did you get? Let everyone know!!
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