How long after tx (sof/led) until antacids?

This topic has 16 replies, 8 voices, and was last updated 8 years, 7 months ago by Dr James.

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27 February 2016 at 10:12 pm #12872
kenbasman
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- Guardian Angel
@kenbasman
Hi there,
I have been bravely putting up with my gastritis/reflux throughout tx with well under the minimum that gilead says you can take of PPI’s and antacids. Have 9 days left of tx. Anybody know if I can start using these meds again immediately after tx, or if i should wait a while. Any help would be greatly appreciated,
Ken

HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18
27 February 2016 at 10:25 pm #12873
Sirchinenge
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@sirchinenge
The advice was to use them 8 hours before you took sob/led I did four extra weeks
of sob/led and took them every other day no way Id be able to live with out them.

Id start back now and make sure you take the anti acids 4 hours before the Harvoni.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
28 February 2016 at 2:07 am #12891
Gaj
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- Guardian Angel
@gaj
Hi Ken,

The recommendations on PPIs and antacids is because Led requires high acidity to be absorbed. So if waiting until EOT to recommence then you should be able to use them again within a few hours of your last pill as it will have been absorbed by then. Extreme caution would be to wait until the following day.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
28 February 2016 at 3:18 am #12897
kenbasman
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- Total: 164
- Guardian Angel
@kenbasman
Thanks Gaj and Sirchinenge,
Just wanted to make sure because all this talk of 1/2 lives of the meds and such is kinda over my head and didn’t know if it needs to be taken in to consideration at EOT…

HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18
1 March 2016 at 1:56 pm #13022
Ariel
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@ariel
I’m having nights of indigestion on sof/led too
Bring on EOT only a month to go
I don’t usually have gastric reflux and I am soooo acidy
Ty for this post cheers Ariel x
1 March 2016 at 2:38 pm #13025
mgalbrai
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- Guardian Angel
@mgalbrai
Hi,
The ledipasvir needs an acidic environment to breakdown and be absorbed properly. So, acid reducers 4 hours before or after dosing. According to Harvoni packaging info, omeprazole (Prilosec) should be avoided, famotodine (Pepcid) is not mentioned.
Makes sense, since Prilosec takes a while to begin to take effect.
I was taking both and another custom compounded med for my horrible dyspepsia. It gradually got better after a year of no alcohol and animal fats. I love bacon. It was guaranteed to give me violent reflux, bloating, nausea and belching this tasteless white foam. It got so bad, I would eat food one day, knowing I would be up all night with dry heaves and reflux you could choke on. Then totally fast the next day and get some sleep. I had two endoscopies to determine the cause. Gastritis. I was a regular drinker with a cast iron stomach until I turned 60. Then, BOOM! Then best relief was to walk. Walk until the food and foam settled. I walked a thousand miles that horrible year, mostly at 2 or 3 in the morning. Good news is no high blood pressure and a resting HR of 50bpm.
So, I haven’t had any problems at all, during or after tx. I do have a beer along. One very good, locally made, very tasty, very potent bottle of Farmhouse Ale.
I don’t think I will ever be able to eat bacon again. The thought of driving the porcelain bus pops up every time I see or smell it.
Oh well, I’m sure the pigs are happier!
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
1 March 2016 at 4:06 pm #13030
Sirchinenge
- Topics: 7
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- Guardian Angel
@sirchinenge
Ken, too be clear as you appear to have stopped taking the anti acid medication whilst
on DAA i think you should start taking them now I think if you take them 4/8 hours before the
Sob/led you’re good to go.

Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
1 March 2016 at 4:21 pm #13032
kenbasman
- Topics: 11
- Replies: 153
- Total: 164
- Guardian Angel
@kenbasman
Hey Mike,
That is strange about the omeprazole being avoided. On the gilead pdf for harvoni they mentioned that you can take 20 mg a or less a day with the meds in fasting condition. I have done just that for about 20 days of tx. I hope i didnt screw up!

HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18
1 March 2016 at 4:26 pm #13033
mgalbrai
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- Guardian Angel
@mgalbrai
That was my PCP who said that. I would go with the Harvoni recommendation.
He simply said these DAAs were so new nobody really knew exactly what to do safely.
His advice: Don’t take anything you don’t have to while on tx.

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
2 March 2016 at 12:30 am #13059
Ariel
- Topics: 3
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- Guardian Angel
@ariel
Ken hi, do you find nights are the worst?
I’m having porridge in the morning around 5.30am which is when I really cannot be bothered with it anymore and it helps settle things down. I’m mixing the oats with milk not water and adding a few seeds and sultanas. Only half a cup of coffee waah
Not long to go anyway good luck for your EOT
2 March 2016 at 12:39 am #13062
LondonGirl
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@londongirl
Only half a cup of coffee waah

I’m off the coffee in the morning now – double whah whah !

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
2 March 2016 at 12:58 am #13068
Ariel
- Topics: 3
- Replies: 1,060
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- Guardian Angel
@ariel
I feel your pain hun, my GP said no but Dr J said go
So I split the difference haha!
I am up so much in the night I would possibly commit a grizzly crime involving a coffee plunger without my half a cup xx
2 March 2016 at 1:13 am #13070
kenbasman
- Topics: 11
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- Total: 164
- Guardian Angel
@kenbasman
Hi there Ariel,
Your gp and Dr.J said no and go to what exactly? I have it worst in the day. I just don’t feel like eating and then to my surprise a lot of the time it does actually make me feel somehat better.,Today is.one of the days i am fighting through with no reflux meds so I am all grumbly in my tumbly ick:' />

HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18
2 March 2016 at 1:18 am #13071
Ariel
- Topics: 3
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- Total: 1,063
- Guardian Angel
@ariel
Hi Ken I was just meaning coffee as LG and I were chatting over
No not taking antacids never have before
Yes hideous gastric acidy gut on sof/led here
The porridge is good
Ariel x
2 March 2016 at 2:13 am #13077
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
I would possibly commit a grizzly crime involving a coffee plunger without my half a cup

I hear you sista!

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
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