Home › Forums › Main Forum › Patient Stories › DAA Side Effects › Is there any evidence of DAAs impacting kidney function?

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  • 19 June 2016 at 2:01 pm #19495
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Just wondering this because at EOT my Estimated Glomerular Filtration Rate has dropped to 71.

    On 18 March the day before starting Tx, it was 87 which is just below normal range.

    At week 4 it was >90

    Should I be worried? :ohmy: :unsure:

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    20 June 2016 at 12:58 am #19510
    Avatar photoPrice
    • Guardian Angel
    • ★★★★★
    @price

    Because the calculation works best for estimating reduced kidney function, the National Kidney Foundation suggests only reporting actual results once values are < 60 mL/min (they state normal values as 90-120 mL/min). An eGFR below 60 mL/min suggests that some kidney damage has occurred. So 60 is the number to watch for. We had someone in our group end up on dialysis after Harvoni BUT he started with a GFR below 60. He probably would have ended on dialysis anyway. P

    20 June 2016 at 1:59 am #19511
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Thanks Price. I guess I’ll have a look at the reading in 3 months when I get tested for SVR12.

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    20 June 2016 at 10:20 am #19534
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Beaches,

    This is something to watch rather than panic about. Creatinine is an indirect measure of kidney function and eGFR is calculated using a formula from this.

    A good first step would be the have a urine dipstick – you should have not protein or red cells in this – if you do that needs looking into further.

    YMMV

    20 June 2016 at 10:39 am #19536
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Hope you are not calling me a dipstick, Doc <img style=illy:' />
    Thanks for the advice. My creatinine level was 78 which is in he normal range (I believe – well Dr Google tells me so).
    I’ll follow up the urine dipstick suggestion, thanks very much for your advice.

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    22 June 2016 at 10:29 am #19726
    Avatar photobeaches
    • Guardian Angel
    • ★★★★★
    @beaches

    Any opinions on this?

    http://www.davidwolfe.com/12-teaspoon-baking-soda-daily-kidneys/

    Genotype 1a
    Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
    Harvoni treatment, started 19 March 2016
    4 week results Bilirubin 12 down from 14 pre treatment,
    Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
    VL <15 down from a lazy 6 million or so

    EOT Results
    Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

    12 Weeks post EOT
    Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
    Cured baby

    22 June 2016 at 11:34 am #19731
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    My chemistry is a little rusty but I suspect you will end up with gas, water and salt in your stomach. ;)

    http://depts.washington.edu/chem/facilserv/lecturedemo/BicarbonateFizz-UWDept.ofChemistry.html

    I’ll leave it to the medical types to comment on any benefits to the kidneys.

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

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