Home Forums Main Forum Patient Stories DAA Side Effects Lactose Intolerance / E110

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  • #10905
    Avatar photodointime
    • Guardian Angel
    • ★★★★★
    @dointime

    Some of the meds coming in pill form contain lactose filler. If you are lactose intolerant then you may experience side effects from the lactose which you might mistake for side effects of the DAAs. Typically that would be some kind of intestinal discomfort but each person is different.

    If your meds are being supplied by your normal source of meds, eg. the NHS, PBS, US Insurance, then I don’t know what you are supposed to do about this. It’s not like there is the choice of asking for a non-lactose version (or might there be?). For people who are paying for their own generics then their friendly compounding chemist would no doubt be able to forego the lactose on request.

    While I am at it, some brand name Harvoni contains E110 which is a yellow dye. This dye can make your urine look darker than it already is. I looked it up and below are a list of side effects.
    dt

    http://www.ukfoodguide.net/e110.htm

    “Side effects are urticaria (hives), rhinitis (runny nose), nasal congestion, allergies, hyperactivity, kidney tumors, chromosomal damage, abdominal pain, nausea and vomiting, indigestion, distaste for food; increased incidence of tumors in animals.
    It appears to cause allergic and/or intolerance reactions, particularly amongst those with an aspirin intolerance.
    Not recommended for consumption by children.
    The Hyperactive Childrens Support Group belive that a link exists between this additive and hyperactive behavioural disorders in children.
    Whilst being a commonly used colour in the UK its use is banned in Norway and Finland.”

    #11578
    Avatar photoChejai
    • Guardian Angel
    • ★★★★★
    @chejai

    Wow, DT that list of sx re E110 is pretty nasty! Although, I have to say reading any list of ‘possible side effects’ for products is always scary, they have to include all possibilities and it does depend on the amount you’re ingesting.
    Since my meds are white, I assume no E110 there (not Harvoni) but I think I read somewhere (Dr James) listed ingredients of meds from Buyers Club and I think Lactose is there. While many of my family members are Lactose Intolerant, I can have a very small amount before I’m affected, so meds would be very minimal.


    QLD Australia ☀️
    G3a HCV 35 yrs Tx naive
    Started Sof/Dac 13/01/16

    Dec ’15
    AST 70
    ALT 89
    GGT 124
    Fibroscore 8.5
    F1-F2
    13 Feb’16 VL UND #woohoo!
    AST 24
    ALT 26
    GGT 50H

    #11583
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Hi Chejai,

    If using the capsules via Buyers Club then my understanding is that there is no lactose or other incipient used, just pure Sof, Dac or Led. That is why the capsules aren’t quite full.


    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

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