Pantoprazole 40 mg and Harvoni (Interaction)

This topic has 11 replies, 6 voices, and was last updated 8 years, 6 months ago by Woobia 22.

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6 April 2016 at 4:57 am #14960
HCV_FIGHTER
- Topics: 1
- Replies: 2
- Total: 3
- Novice
@hcv_fighter
Hi Every one,

I have question is there any interaction between “Pantoprazole 40 mg” and Harvoni ?

I’m under treatment for 6 week with “Pantoprazole 40 mg” and soon I’m going to start my Harvoni for 12 weeks.

I asked my physician and he not answer me clearly he said no problem ! with no details.

Thank you
Merai

This Too Shall Pass
6 April 2016 at 5:56 am #14962
Paul-Jarman-facebook
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- Guardian Angel
@paul-jarman-facebook
http://www.hep-druginteractions.org/interactions/43391

Summary: Coadministration has not been studied, but data with omeprazole show only a small decrease in ledipasvir exposure. Proton pump inhibitor doses comparable to omeprazole 20 mg can be administered simultaneously with ledipasvir/sofosbuvir. Proton pump inhibitors should not be taken before ledipasvir/sofosbuvir. Description:
Proton pump inhibitor doses comparable to omeprazole 20 mg can be administered simultaneously with ledipasvir/sofosbuvir. Proton pump inhibitors should not be taken before ledipasvir/sofosbuvir.
Harvoni Summary of Product Characteristics, Gilead Sciences Ltd, November 2014.

Proton-pump inhibitor doses comparable to omeprazole 20 mg or lower can be administered simultaneously with ledipasvir/sofosbuvir under fasted conditions.
Harvoni US Prescribing Information, Gilead Sciences, October 2014.

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
6 April 2016 at 7:37 am #14968
Gaj
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- Guardian Angel
@gaj
Hi HCV_FIGHTER and welcome.

As Paul explains from the link (very useful link for anyone on treatment and needing to use other medications) and quote he gave you it can certainly be done if you do it with the correct timing which your doctor should explain clearly to you. As it happens someone else asked the same question yesterday in the below linked post.

http://fixhepc.com/forum/new-to-forum/870-new-member-from-california.html#13915

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
6 April 2016 at 1:24 pm #14979
mgalbrai
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- Guardian Angel
@mgalbrai
Hi HCV_Fighter,
Welcome to FixHepC.
Check the link from GAJ.
Coach Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
6 April 2016 at 11:39 pm #14996
HCV_FIGHTER
- Topics: 1
- Replies: 2
- Total: 3
- Novice
@hcv_fighter
Hi
Thanks for every one, I went back to my doctor and I show him the gilead durg perscrption and finally he agreed and he said “yes there is an interaction” I stopped taking Pantoprazole and I started my first pill of Harvoni today
Thank you again guys

This Too Shall Pass
7 April 2016 at 1:17 am #14998
kenbasman
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- Guardian Angel
@kenbasman
That was smart methinks. I was on pantoprozole before tx and always had the idea that it was like a stronger kind of omeprazole PPI. First thing is after a couple of days of treatment my gastritis/reflux got a lot better. That lasted about 4 weeks and then when things really started acting up i followed the directives on gileads website which says you can take 20 mg or less of omeprzole ( or it’s equivalent?!?) at the same time as your harvoni in fasting conditions in the morning. I ended up taking about 32 omeprazole pills that way during my 12 weeks of treatment. I am now 4 weeks past tx and waiting for my VL results, kinda wishing i wasnt such a wuss and just put up with the reflux problems. Should know by friday if i am still UND.
Just saying this to put it in perspective from someone who has finished treatment and is on the edge of my seat waiting to see if i still have this thing licked and regretting the days I got up in the morning during tx and let myself take the omeprazole in case of relapse…

HCV 35 yrs G1a F3 Tx naive
started Lesovir-C 15/12/2015
pre tx: VL 5,250,000 ALT 374 AST 208
FIBROSCORE 10.4

4 weeks tx ALT 29/ AST 33. VL < 12 UI/mL 8 weeks tx ALT 29/ AST 34. VL UND 4 weeks after tx UND. SVR4. ALT 24/AST 18
7 April 2016 at 1:20 am #14999
mgalbrai
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- Guardian Angel
@mgalbrai
Hey,
What a name!
We are all that!
Keep asking. The answers are here.
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
7 April 2016 at 9:25 am #15016
HCV_FIGHTER
- Topics: 1
- Replies: 2
- Total: 3
- Novice
@hcv_fighter
Paul-Jarman-facebook , Gaj , kenbasman , mgalbrai thank you guys your answers were very professional please keep it up and sure I’ll be here always with such wonderful people like you.

See you Soon

This Too Shall Pass
7 April 2016 at 1:05 pm #15017
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Hey Ken,
Its amazing how bad a messed up stomach can make you feel. I was lucky. I think the virus and the boxes of cheap red wine and the shots of whiskey on cold days at the golf course and eating fried everything probably and drinking beer like it was water had something to do with it. When those were removed from the equation. The stomach issues just stopped.
Amazing.
m

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
6 June 2016 at 9:58 am #18496
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
Just read this and it blows me away as when first told I had a problem was Dec 2012 and the Doc who was relieving was from Africa, nice guy but I couldnt understand one word he said. He gave me a letter to take to Perth and I was sent to a Plastic Surgeon who just laughed at first.

I told him i was having trouble swalloowing and sore around the throught area and Had read where Chris Munce and my Bro in law had cancer of the throught both very fit. He said his Secretary was phoning allk around Perth trying to get me in to see someone as he said the Scans showed trouble in the liver.

He then prescribed me Pantaprozille and I have been on it ever since, last 18 months twice a day. Should I just stop taking them and see how it goes.
I am on the least meds atm for years as at one stage I was taking 25 tablets and peg injections per day. now down to Sof / dac, 1x pantaprozille, 1x Rifaximin, 2 Fruisemide am and pm same except no sof/dac. I was given till March to live but I dont think they have a clue, even though I have been in a coma twice and hospitalized 6 times this year. Got so bad I was unable to dress myself make a cup of tea, put a seatbelt on unlock a door, shower. change a toilet roll make a sanga, fuk I felt useless. Lucky I didnt have Doc Nitchke phone #

Been feeling good last 2 weeks and due down again on 23rd June for clinic, which is an absolute joke. You see someone new each time and they spend the first 10 min finding out what meds you are on etc then say see you next time the front desk will make an appointment for you.

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
6 June 2016 at 10:42 am #18498
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Hi Barry,

Pantoprazole can be a problem with Harvoni because it reduces stomach acidity and the Ledipasvir in Harvoni requires good stomach acidity to be fully absorbed. The Sofosbuvir and Daclatasvir you are taking don’t require stomach acidity for absorption so the pantoprazole won’t reduce their effectiveness.

But perhaps you are wondering about whether you need to keep taking it based on the comments from Ken and Mike about improvements in their stomach condition during treatment?

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
6 June 2016 at 10:55 am #18499
Woobia 22
- Topics: 2
- Replies: 32
- Total: 34
- Treatment Warrior
@woobia-22
Yeah thanks I am glad it doesn’t effect sof/dac but it would be good to have less gut pain as I have an enormous hernia and a couple of smaller ones. I have swollen feet and legs and have upped my Frusimide .

First diagnosed Nov 2012 with Hep C 1a End Liver disease
Failed peg and Sof/dac
Given 18 mths to live Aug 2014
Failed sof/dac July 2015
Sep 2015 given till March 2016 to live as nothing they can do
Sourced a supply of sof/dac from India told I was a fool by staff at SCGH
Been in a coma twice 2016 6 stays in Hospital
Last 4 weeks have been unreal back into life again
Hope No One else is treated like Shit by Med Specialists as the Nurse are UNREAL The Good Doc Freeman is genuine Barry Ashton

Barry Ashton
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