Please check for medication interactions (+ website link)

This topic has 28 replies, 12 voices, and was last updated 7 years, 9 months ago by Dr James.

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17 September 2015 at 11:51 am #1321
Dr James
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- Guardian Angel
@fixhepc
Like many medications the new Hep C medications can interact with other medications you might be taking.

Please use this site to check is any medications you’re on will interact with medications you’re planning to take.

http://www.hep-druginteractions.org/checker

YMMV
17 September 2015 at 12:22 pm #1324
emilio
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@emilio
Hi James

Could you please explain how one would manage being on setraline/zoloft when commencing treatment of sofosbruvir and daclatsavir? I’ve checked out the interactions table and still don’t understand the ramifications? I guess I’m asking for myself who has remained on this AD since my last treatment and for all hepers, as many would be in the same situation. If there is any question on interaction I’d like to wean off the AD prior to commencing, maybe? Em

Edit: I’m on 50mg daily, well most days when I remember!
18 September 2015 at 4:03 am #1327
Dr James
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- Guardian Angel
@fixhepc
http://www.hep-druginteractions.org/checker

So if you go through the process and
- tick Sofosbuvir + Daclatasvir on the first page,
- next
- the alphabetical search is the default
- next
- then find and tick Sertraline
- scroll down to finish
- you will see the “potential interaction”.
You can get a PDF of that as well.

However if you go and look at some of the research you can be reassured to find:

Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers.

Which says:

These results demonstrate in vivo that, unlike nefazodone, venlafaxine, sertraline, and fluoxetine do not possess significant metabolic inductive or inhibitory effects on CYP3A4.

So you’re good to take the 60 mg Daclatasvir dose, rather than have to reduce to 30 mg or stop the problem medication.
Attachments:
- HepDI_Sertraline.pdf
YMMV
18 September 2015 at 4:45 am #1329
emilio
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@emilio
Thanks James

I was looking at another interactions document and also saw this one but didn’t realise it was a ‘tool’ as such. Thank you. Em
18 October 2015 at 12:27 pm #2437
Dan
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@dan
I’m allergic to certain food (strawberries, citrus fruit, chocolate) and penicillin. Do I need an allergy test before going OS Dac+Sof or Harvoni treatment. If yes what ingredients should be tested?

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
18 October 2015 at 12:57 pm #2439
Alsdad
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@alsdad
You should be fine Dan. Here are the ingredients for:

Sovaldi

Tablet core

Sofosbuvir
Mannitol (E421)
Microcrystalline cellulose (E460)
Croscarmellose sodium
Colloidal anhydrous silica (E551)
Magnesium stearate (E470b)

Film-coating

Polyvinyl alcohol (E1203)
Titanium dioxide (E171)
Macrogol 3350 (E1521)
Talc (E553b)
Yellow iron oxide (E172)

Daklinza

Tablet core

Daclatasvir
Anhydrous lactose
Microcrystalline cellulose
Croscarmellose sodium
Silicon dioxide (E551)
Magnesium stearate

Tablet film-coat

Hypromellose
Titanium dioxide (E171)
Macrogol 400
Indigo carmine aluminum lake (E132)
Yellow iron oxide (E172)

Harvoni

Tablet core

Sofosbuvir
Ledipasvir
Copovidone
Lactose monohydrate
Microcrystalline cellulose
Croscarmellose sodium
Colloidal anhydrous silica
Magnesium stearate

Film-coating

Polyvinyl alcohol
Titanium dioxide
Macrogol 3350
Talc
Sunset yellow FCF aluminium lake (E110)

Just put any of those fancy names into Google to find out what they are and what they do.
27 October 2015 at 12:16 pm #2839
berrinice
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@berrinice
Can anyone tell me if CT contrast fluid iohexol would interfer with anti virals sof,dacl&riba. I looked up the chart but iohexol isn’t listed. kindly
27 October 2015 at 12:34 pm #2842
Gaj
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@gaj
Thanks berrinice, hadn’t thought of that but something I also need to know for when my meds arrive.

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
28 October 2015 at 12:42 am #2880
Dr James
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@fixhepc
It will not cause any problems with your medication. The 1/2 life is 2 hours so the levels in your blood look like

0 1
2 1/2
4 1/4
6 1/8
8 1/16
10 1/32
12 1/64
14 1/128
16 1/256
18 1/512
20 1/1024
22 1/2048
24 1/4096

etc. In other words it takes very little time to get rid of it from your system.

YMMV
7 November 2015 at 4:51 pm #3482
LondonGirl
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@londongirl
Does anyone know whether you can take Alpha Lipoic Acid (Antioxidant) on treatment?

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
4 January 2016 at 3:39 pm #7947
LondonGirl
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@londongirl
Dear all, Me again !

Still asking about the Alpha Lipoic Acid – Have taken this on initial diagnosis, VL and bloods came right down, although this could also have something to do with a seriously healthy eating plan.

Stopped taking it for a while (it’s quite expensive) – VLwent up and bloods worsened, including Alt 61- 114.

Am currently back on it – Alt back down to 76, last VL 900,000, waiting on latest VL result.

but my question remains, does anyone know if I can continue with taking ALA when on treatment?

Best wishes to all

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
4 January 2016 at 5:16 pm #7953
Dan
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- Guardian Angel
@dan
Hi LG. Dr Freeman answered your questions in a separate thread.

fixhepc.com/forum/experts-corner/534-supplements-with-evidence.html

Where do you buy it from H&B?

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
4 January 2016 at 5:31 pm #7954
LondonGirl
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- Guardian Angel
@londongirl
Hi Dan, Thanks, have just seen that – Great news. Think I sent you this info / links a while ago? but prob too many emails ago now I would imagine!

I have been advised against H & B by a medical/scientific herbalist – I only use Lamberts, you can google them , they are online. They definitely seem to help me anyway and started the B12 again, pulsating feeling seems to have calmed down too, could be coincidence, then again it might be as a result

I do know that ages ago I did some very thorough research before buying and advising, read medical papers etc

Warm wishes to you and hope the eczema starts to clear soon.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
4 January 2016 at 5:43 pm #7956
Dan
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- Total: 203
- Guardian Angel
@dan
Yes, I have the link. Which one do you normally buy?

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
4 January 2016 at 6:03 pm #7960
Dan
- Topics: 6
- Replies: 197
- Total: 203
- Guardian Angel
@dan
Thanks, found it.

Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
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