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It seems the real world figures for g3’s isn’t quite as good as 96% but given that the current meds are still relatively new it may take time for treatment regimes to be perfected.
Two time relapser.
SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated
GT 3 – about 28 yrs with HCV
Ally-3 trial participant numbers were fairly low. As Paul says with more people having treated over time the real world rates have been lower for Gt3s so longer or stronger treatment is a good option for us.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks Gaj, Paul and Split, Donna I have tried to answer you other post re your path for you in the other blog you wrote, friends, Dr J, you may wish to check on that.
With all my empathy,
Ariel
ALT and AST are released from damaged cells. Everyone has some levels as part of the wear and tear of daily life but most people with HCV have raised levels although the amount they are raised varies depending on the damage occurring when the test was done. Even though your levels were within the average normal range prior to treatment you still had raised levels compared with your normal as shown by them decreasing x2 and x4 during treatment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Excellent explanation. Liver functions – at least the liver enzymes – are not about function. They are about damage and how much dead liver stuff is floating around in your blood.
For you that was not much at the start, and even less now. About 5% of people have normal enzymes with their HCV. These people often have high viral loads, so it probably means their immune system is not doing much about the HCV (ie killing the liver cells it has infected).
As Gaj says the normal range simply represents where you find the values for 95% of the people. 2.5% of “normal” will by definition have lower levels, 2.5% will have higher levels and while most people will be in the mid range, some will be low normal and some high normal.
That’s normal
which is probably why it’s called a normal distrubution – the shape of the curve with most in the middle, and a tail out each side is called “the bell curve” for pretty obvious reasons.
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