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  • 11 October 2016 at 1:35 am #23732
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    Thanks, everybody. I woke up and read these responses and got a little choked up. Thank you all.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    31 October 2016 at 6:05 pm #24084
    vitrus
    • Topics: 1
    • Replies: 35
    • Total: 36
    • Treatment Warrior
    • ★★★
    @vitrus

    Summary of trials data to help one compare sof/vel with other effective treatments
    http://congress-ph.ru/common/htdocs/upload/fm/gepatology/2016/prez/1-3-2.pdf
    http://www.natap.org/2016/AASLD/AASLD.htm

    In-vivo resistance analysis (sof/vel, all phase III trials).
    Enough statistics for some genotypes.
    http://www.natap.org/2016/EASL/EASL_15.htm

    Gen 1b
    VL pre treatment 29000 ME/ml
    AST 32 ALT 94, F0
    Started treatment 13 January 2017
    Generic sofosbuvir/velpatasvir (Incepta)
    VL 9 days into treatment <300 (undetected)
    AST 13.8 ALT 22
    Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
    Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.

    6 November 2016 at 9:47 pm #24201
    vitrus
    • Topics: 1
    • Replies: 35
    • Total: 36
    • Treatment Warrior
    • ★★★
    @vitrus

    Rapid Virological Response reported in 1 case.
    http://hepcfriends.activeboard.com/t62645983/epclusers-corner/
    One should drink lots of lots of water with velpatasvir to avoid dehydration and take pills at one time of the day. Side effects are said to be more than manageable, mild headaches and fatigue, water helps.

    Gen 1b
    VL pre treatment 29000 ME/ml
    AST 32 ALT 94, F0
    Started treatment 13 January 2017
    Generic sofosbuvir/velpatasvir (Incepta)
    VL 9 days into treatment <300 (undetected)
    AST 13.8 ALT 22
    Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
    Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.

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