Someone did the dream combo: sim+harvoni+riba

This topic has 7 replies, 5 voices, and was last updated 9 years, 1 month ago by miko3.

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30 October 2015 at 2:58 am #3046
tweakmax
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New hepatitis C treatment a ‘game changer’
30 October 2015 at 10:03 am #3050
Paul-Jarman-facebook
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The poor guy had 6 treatments before he was cleared.

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
30 October 2015 at 10:36 am #3051
tweakmax
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Yes poor guy

Now he svr
4 November 2015 at 6:24 am #3292
emilio
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Any news on simprevir and where one might obtain a generic and afforable version. I was researching a x 3 of sof/sim/rib before i found mesochem and buyers. Could access all in India except sim. Although was being mucked around by one distributor who said he had access but didnt. Em
4 November 2015 at 7:12 am #3300
tweakmax
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Is it possible to ask australians to get for u? are u in aussie?
4 November 2015 at 2:44 pm #3323
miko3
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emilio
I made several attempts a few months ago to access simeprevir in India,as i was at the time interested in the sof dac sim combo..I got a number of replies at prices that were unaffordable.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
4 November 2015 at 2:59 pm #3324
dointime
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There was a paper written some time ago when the DAAs were a concept but not yet a reality. Sorry I can’t find the link to it but the gist was as follows:

Mathematicians got together with medical specialists studying the hepc virus and how it mutates to escape threat. They calculated that if the virus was disabled in 3 different places at the same time then there was no possibility for it to escape via mutation. ie. 3 drugs with different actions would be a guaranteed success in eradicating any virus that was exposed. To date I don’t know if their theory has been disproved but the concept made sense to me. I don’t know if ribavirin was counted as one of the 3 DAAs.

dt
5 November 2015 at 3:50 am #3340
miko3
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http://www.natap.org/2015/EASL/EASL_30.htm
this was for sof dac sim,but the concept was to treat people with advanced fibrosis over a 12wk period and did not include riba.
The same concept would probably apply to a sof led sim regime.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
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