If < LLOQ still there is chance of cure. With Vikiera Pak the LLOD (Lowest Limit of Detection) is the measure of SVR but with Harvoni LLOQ is the measure. "Relapse was a secondary endpoint, which was defined as HCV RNA greater than or equal to LLOQ with 2 consecutive values or last available post-treatment measurement during the posttreatment period after achieving HCV RNA less than LLOQ at end of treatment." It is intersting that with the regiment including sofosbuvir, detected at EOT and even later still have higher cure rate. But of course the longer the treatment the better because the more defective replication complex is induced "There must be other reasons to explain the high SVR," Guedj said. "We think most of the [newly produced] virus may be uninfectious...treatment may have the effect of replacing a working replication complex with a defective replication complex, which explains how most patients could clear the virus in 6 weeks." "Low negative predictive values of HCV RNA at week 4 underscore the importance of continued therapy for patients who fail to achieve undetectable levels of HCV RNA early on during treatment because the likelihood of achieving SVR12 is still high," the researchers concluded. "Contrary to past experience with interferon-containing treatments, the presence of detectable HCV RNA at EOT [end of treatment] is not predictive of relapse in these studies." http://www.aidsmap.com/HCV-viral-load-levels-during-treatment-and-speed-of-decline-do-not-predict-cure-with-interferon-free-therapy/page/2962856/
An uninfectious virus may only explain these data of this person:
Started Harvoni 11/26/14 for 8 wks
Completed 8 wks Harvoni 01/20/15
EOT RNA Quant result: Detected 29
7.5 wk post tx: Detected < LLOQ(12) 11 wk post tx: UNDETECTED SVR12 24 wk post tx: UNDETECTED SVR24; AST 26; ALT 22 48 wk post tx: UNDETECTED SVR48

It works, post here any step of treatment.

I think too that the cost far lower than 12USD. Thus I agree that 750 USD for 12 weeks is possible. But I dont know for reliability of such suppliers.

olegiva,

You cant buy directly from Hetero, Natco,…

Investigating many patients cured at others forums, being UND or < LLOQ (<15) is insignificant. Even patients that have been detected at EOT but < LLOQ have been cured. At the time of trials with Harvoni the LLOQ have been 25 IU/ml, now they have updated to 25 and 15. Other patients on Harvoni have been UND at 4 weeks and then detected at 6 weeks followed with UND at 8 weeks and still cured with three months treatment. From Gilead Page: HARVONI was administered once daily by mouth in these trials. For subjects who received ribavirin (RBV), the RBV dosage was 1000 mg per day for subjects weighing less than 75 kg or 1200 mg per day for subjects weighing at least 75 kg. RBV dose adjustments were performed according to the RBV labeling. Serum HCV RNA values were measured during the clinical trials using the COBAS TaqMan HCV test (version 2.0), for use with the High Pure System in ION-3, ION-1, ION-2, SIRIUS and ION-4 studies or the COBAS AmpliPrep/COBAS Taqman HCV test (version 2.0) in ELECTRON-2, and 1119. The COBAS TaqMan HCV test (version 2.0) for use with the High Pure System has a lower limit of quantification (LLOQ) of 25 IU per mL and the COBAS AmpliPrep/COBAS Taqman HCV test (version 2.0) has a LLOQ of 15 IU per mL. Sustained virologic response (SVR12) was the primary endpoint and was defined as HCV RNA less than LLOQ at 12 weeks after the cessation of treatment. Relapse was a secondary endpoint, which was defined as HCV RNA greater than or equal to LLOQ with 2 consecutive values or last available post-treatment measurement during the post-treatment period after achieving HCV RNA less than LLOQ at end of treatment.

http://fixhepc.com/forum/experts-corner/559-do-not-worry-detected-or-undetected-if-below-lloq.html

Why or how Hep C treatment can re-activate Hep B in some rare cases?