Forum Replies Created
-
AuthorPosts
-
Congratulations,on SVR4 Sven!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi all, I’ve moved these Voxilaprevir posts from the Beacon Sofosvel release thread to this one.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi countless,
I suspect that if you haven’t been experiencing a problem till tonight then your may well be due to the guests and coffee. However if it continues to be a problem here is some info on how to transition to an earlier time.
http://fixhepc.com/forum/patient-stories/326-time-of-day-to-take-medication.html#3003
Sorry, can’t help with the date display although the “search” function does display the calendar date and time of posts it finds.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
.
I haven’t seen VL expressed as fmols, do you mean Log10 scale?
In which case it is a logarithmic progression which I don’t have the skills to explain how to calculate but can supply the below approximations. (Sorry about the wonky columns, too much work to tabulate on an iPad )Log10 iu/mL
7.0 10,000,000
6.9 7,943,282
6.8 6,309,573
6.7 5,011,872
6.6 3,981,072
6.5 3,162,278
6.4 2,511,886
6.3 1,995,262
6.2 1,584,893
6.1 1,258,925
6.0 1,000,000
5.9 794,328
5.8 630,957
5.7 501,187
5.6 398,107
5.5 316,228
5.4 251,189
5.3 199,526
5.2 158,489
5.1 125,893
5.0 100,000
4.9 79,433
4.8 63,096
4.7 50,119
4.6 39,811
4.5 31,623
4.4 25,119
4.3 19,953
4.2 15,849
4.1 12,589
4.0 10,000
3.9 7,943
3.8 6,310
3.7 5,012
3.6 3,981
3.5 3,162
3.4 2,512
3.3 1,995
3.2 1,585
3.1 1,259
3.0. 1,000
2.9 794
2.8 631
2.7 501
2.6 398
2.5 316
2.4 251
2.3 200
2.2 158
2.1 126
2.0 100
1.9 79
1.8 63
1.7 50
1.6 40
1.5 32
1.4 25
1.3 20
1.2 16
1.1 13
1.0 10
0.9 8
0.8 6
0.7 5
0.6 4
0.5 3
0.4 3
0.3 2
0.2 2
0.1 1
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Welcome Steve67,
As you say, the test was conducted by only one diabetic patient and reading through the article I found this disclaimer.
“Nonetheless, do take into account that these numbers come from the measurements of Chris Hannenmann, a diabetes patient, and cannot be regarded as a scientific proof.”
My recommendation would be that anyone who suspects they may have symptoms of diabetes per this thread should see their doctor for a diagnosis rather than purchasing a meter. Most doctors will already have or will have access to a meter which will avoid what will turn out to be unnecessary expenditure if you aren’t diabetic. When you are diagnosed diabetic seems like the best time to start researching the most suitable meter for your own use.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Pauldavid,
My understanding is that while we all seem to be a bit different there doesn’t seem to be much correlation in the level of symptoms and damage between genotypes with the exception that genotype 3 is thought to be more aggressive in how quickly it impacts as well as more difficult to treat.
Raised liver functions indicate damage occurring so if yours are okay then at very least you are stable but many patients are finding that their fibrosis/cirrhosis scores have improved post treatment so I expect after three years there is a very good chance you will have too despite not being able to test it.Sadly, I hear you on the ignorance and stigma, though it does appear to be very slowly improving.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Also i have read that the virus continues to after EOT?
Okay, so you will probably always have antibodies to the virus after successfully completing treatment and achieving SVR. This is a normal indication with many viruses our immune systems have fought with such as flu, etc. and doesn’t mean we still have live virus in our bodies. Although with HCV having antibodies doesn’t give us immunity to reinfections.
As for what SVR actually means, Dr Freeman wrote a good post below that should provide some confidence for the future.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi TTL,
Sorry to hear that your previous treatments failed you. Fortunately there are now better options available or in the pipeline. Voxilaprevir in combination with Sof/Vel is one that does look promising for the future per this thread https://fixhepc.com/forum/relapse-corner/1263-voxilaprevir-a-new-protease-inhibitor.html#22461
I’m not an expert but you don’t appear to have treated with a NS5a combination, just with Sof/Riba? If that is the case and assuming you don’t have a Sofosbuvir resistance (extremely unusual) there may well be current options that would be effective for a genotype 2b patient without needing to wait for Vox to become available such as Sof/Daclatasvir or Sof/Velpatasvir. If you can provide a bit more information about how soon after finishing treatment you relapsed and what your fibrosis levels are that may assist others to comment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
27 October 2016 at 12:56 am in reply to: I want to buy sofosbuvir (Sovaldi®) and daclatasvir (Daklinza®) #24031Hi Sven,
Apparently lukemeister1990 has dealt with Vicek, however he is not a verified supplier on this site so we are unable to vouch for him.
If you do have an reliable UK address that you can ship to then you can source these medications via the FixHepC sponsored Redemption 2 clinical e-Trial https://fixhepc.com/redemption-imagine-freedom-from-hepatitis-c or alternatively there is further information on other known reliable sources here https://fixhepc.com/forum/daa-access/457-warning-to-online-buyers.html
I would also recommend you read the “Getting Treated” section of this site linked towards the top of the page and please feel free to ask any questions you may have either in the forum or via email to help@fixhepc.com
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi nads,
Hopefully Dr Freeman will comment further about your ALT/AST although they can be affected by other things than liver function so your AF and stress of son’s health probably play a part.
But regarding your VL testing, I looked up the test you were given: http://www.hologic.com/products/clinical-diagnostics-and-blood-screening/assays-and-tests/aptima-hcv-quant-dx-assay
if you read through all the detail you will find the below information about its accuracy levels.
The LLoQ of the Aptima HCV Quant Dx assay is 10 IU/mL.
…..it gives accurate quantity readings down to 10iu/mL
The Aptima HCV Quant Dx assay’s Limit of Detection (LoD) is 4.3 IU/mL in plasma (3.9 IU/mL in serum).
…….and detects down to ~4iu/mL
So it appears to be one of the more accurate VL tests. I doubt you will do much better outside of a research lab at this point in time and the Aptima qualitative test is only accurate down to 5.3iu/mL which is very slightly less (but so close it could go either way at those levels).
Linear regression analysis determined 5.3IU/mL ≥(95% probability) as the limit of detection for the Aptima HCV RNA qualitative assay.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Thanks Tommy, you make some very valid points. All those who are now considered trusted suppliers by this site have gone through a similar process of checks before they reached that status.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Greetings Maged Fares,
Currently you are not recognise as a trusted supplier of HCV medications by this site. As a result I have removed your contact details pending further information from yourself that will allow us to verify your inclusion here. Please read the information in the below link regarding how to seek verification as a distributor of these medications. Should you wish to continue please contact help@fixhepc.com email address or myself via private message on this site. Thank you.
https://fixhepc.com/forum/distributor-s-market/957-distributor-s-market-reasons-rules-warnings.html
(I have also moved your post to a more suitable section of the forum.)
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
15 October 2016 at 11:24 am in reply to: Indian Generic Velpatasvir Launched (PENDING VERIFICATION) #23888Thankyou tweakmax,
You apparently have more information than I do.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
15 October 2016 at 11:00 am in reply to: Indian Generic Velpatasvir Launched (PENDING VERIFICATION) #23882I believe Monkmed did that at the top of this thread Tweakmax. I can also see Bull Pharmachem has Velasof listed on Indiamart.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
15 October 2016 at 3:52 am in reply to: RO patient won in court the right to interferon-free treatment #23870The lack of price transparency on a market is quite irritating, especially when talking about people’s health.
I agree. I suspect the price of just under $70,000 that beaches quotes is from the pharmacist labels on her medication which state a “Full Cost” of that amount, they will also list the price she pays which will be about $39 X 3. Other types of medicine don’t seem to state a “full cost” price so I wonder what makes these ones so special? I have seen a number of different pricing models thrown around for Australia but no one from the government has confirmed any of them. I suspect we will never really know the deals that our governments are negotiating with the pharmaceutical industry. However, we do know that $1 billion has been allocated over 5 years to pay for HCV treatments so about $200m per year. The latest estimates have just been published on Australian patients treated and it is estimated that it is approx 26,300 for the period March to July 2016 so if the medication really was costing $70k per treatment Australia has spent $1.8 billion in that time and has already exceeded the five year budget by 80%! I very much doubt that and believe the real price we are paying is far lower and probably capped as many have claimed.
http://kirby.unsw.edu.au/sites/default/files/hiv/attachment/Kirby_HepC_Newsletter_Issue5_2.pdf
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
-
AuthorPosts