Forum Replies Created
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Great news Matt, congratulations!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Over the last 11 months I’ve noticed there really doesn’t seem much consistency in the way different labs and doctors report these results.
But being told “undetected” twice by the doctor is the real deal. Happy for you Sven!
Happy for you Sven!
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hey, beaches,Don’t feel shy on my behalf, the rest of you have all earned the right to celebrate as hard as you want! I’ll be along to join you as soon as I get me laces tied.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Interesting question J,
In the Australian case*, what we have heard from the advocacy groups is that the PBS (correctly taxpayers) are apparently paying a total of A$1 billion for up to 65,000 treatments over the next five years with any treatments above that quantity being provided at nil cost by the pharmaceutical companies. Keep in mind that those numbers are supposedly “per treatment” rather than per 12 weeks of a particular drug although I assume there will also be some sort of rollover and annual quotas fine print in the agreements that attempts to favour the company bottom lines. Overall though, that works out to less than A$16k per treatment assuming we get the full numbers treated and as low as A$4.5k if we manage to treat every one of the estimated 230,000 with HCV in this country. The latter being an unlikely but worthy goal.
Those costs are still quite high for a drug that costs less than US$100/A$130 to manufacture and up to nearly 10x higher than generics pricing however given the capped pricing and the Australian government’s likely continued adherence to patent laws a reasonably strong case can be made for advocacy for as many Australians as possible to access what is effectively a fixed level of PBS funding within the five year period. i.e. Once we hit target taxpayers don’t fork out any more for extra patients to treat so effectively we are renegotiating a lower pricing structure for each extra person.
(* I believe that the improved access/pricing situation in Australia, while no doubt due to some hard headed negotiations by our government, was enabled because of some very effective grass roots advocacy for generics by a couple of Tasmanians and some NSW pharmacies that definitely were not funded by big pharma
)
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Great news Bob, well on your way.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Donna,
With or without food is fine for Sofosbuvir and Daclatasvir. As I noted previously taking without food just suited my routine best and I didn’t notice any problems taking them on an empty stomach. Others have felt they were better off taking with food. The only caution is in the Daclatasvir instruction sheet around taking it with a large, very high fat meal which may reduce adsorption a bit.
Effect of Food on Oral Absorption
In healthy subjects, administration of a daclatasvir 60 mg tablet after a high-fat, high-caloric meal (approximately 951 total kcal, 492 kcal from fat, 312 kcal from carbohydrates, 144 kcal from protein) decreased daclatasvir Cmax and AUC(0-inf) by 28% and 23%, respectively, compared with fasted conditions. A food effect was not observed with administration of a daclatasvir 60 mg tablet after a low-fat, low-caloric meal (approximately 277 total kcal, 41 kcal from fat, 190 kcal from carbohydrates, 44 kcal from protein) compared with fasted conditions [see Dosage and Administration (2)].
http://packageinserts.bms.com/pi/pi_daklinza.pdf
So as long as you don’t make a habit of taking them with a Large Big Mac, thick shake and Sunday meal you will be fine either way.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi m and Sven,
Qualitative tests just give a Detected or Undetected result. On the other hand Sven’s result is definitely quantitative as his report states it as <15. But if it is in the <15 range but detected then it would usually include a statement to that effect per the quote from the Cobas Taqman V2 assay instructions below or alternatively it will state that it is undetected.
Results less than the quantitative range of the assay will be reported
as “HCV RNA detected, less than 15 IU/mL”.Sven’s result only gives <15 without also stating whether detected or undetected so is ambiguous but as Fitz says, Sven's doctor will be able to clarify the correct answer in more detail.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sven,
15 iu/ml is the limit that the quantitative test assay the lab used can accurately record rather than necessarily being your result. The printout you have shown us looks like the report from your doctor’s surgery which sometimes only reports the <15 number rather than the full lab report indicating detected or undetected. So he is the best person to ask which it is.
There are quite a few posts on the subject in the below section of the forum.
https://fixhepc.com/forum/viral-load-and-svr.html
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Donna,
Lots of good information there from Ariel. I’m not a doctor either but from what I can see you can afford to relax a little as none of your results seem to be cause for alarm and you have several weeks or more to make a decision regarding length of treatment. One piece of information that would assist people to understand your situation a little better is whether the test results you have listed were taken prior to starting treatment or are they based on your current status after about two weeks medication?
Regarding length of treatment and your nurse’s comments, with more people treating it has been found that GT3 is proving a little more difficult to treat than those clinical trials anticipated so some are suggesting a longer course of treatment to increase the chances of clearing the virus the first time round. Although you may only increase your chances by a few percent it seems to make some sense to do so first try if you can afford it as an individual but for a government it works out cheaper to treat everyone for 12 weeks, cure most of them then go back and retreat the failed 5-10% for 24 weeks the second time round. That is the context of Dr Freeman’s comments in the other thread to Lukemeister who was also a GT3 with F2 fibroscan although he had prior (unsuccessful) treatment experience.
https://fixhepc.com/forum/gt3/1290-question-to-dr-freeman-treatement-length.html#21378
I hope that helps you to clarify your thoughts and fortunately you have a few weeks to make the best decision for your circumstances. As Ariel suggests, have a look around and please feel free to ask if you have any questions.
Here are some further links I quickly found on length of treatment for GT3.
https://fixhepc.com/forum/questions-and-answers/939-zero-12-14-16-18-or-20-weeks-is-the-answer.html#14900
https://fixhepc.com/forum/gt3/885-post-treatment-gt-3a.html#14166
https://fixhepc.com/forum/gt3/861-alt-ast-ratio.html#14152
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Ally-3 trial participant numbers were fairly low. As Paul says with more people having treated over time the real world rates have been lower for Gt3s so longer or stronger treatment is a good option for us.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi argemor,
Looking at the current situation in Venezuela it does appear that it may be difficult to directly import medicines but I can’t speak for Monkmed/Redemption ability to ship there. The best way to seek answers would be to directly contact FixHepC via email at help@fixhepc.com explaining where you are and your situation and you can also ask about the possibility and legality of shipping to a friend in another country. They deal with these sort of questions about various countries import regulations all the time and will recommend the best course of action for you.
Best wishes for a successful treatment.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Such wonderful news Ariel!
Wishing you perfect waves.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Congratulations Geno1b4!
Wonderful news to hear that both types are gone.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
Hi Sven,
It isn’t a side effect that gets brought up all the time and on a few other sites I have seen people commenting that their dentist noticed improvements to their dental health while they were on treatment. So if you are adequately hydrated and still have the problem it may pay to be cautious and check it with your GP or normal doctor first assuming they are accessible. That way they can check for any other potential issues and if they find nothing then as FF66 points out, you can get topical products that can be used to treat dry mouth.
G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
