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Hi Gaj
Thanks for clarifying that … it’s just another exercise in pragmatic competence, which was touched upon with the discussion of semantics on another thread.
For those of us who have suffered serious head injuries, pragmatics can be an issue.
I too have needed to adjust my belt by several holes and will now have to buy some new jeans as they are hanging off me.
I’m innately lazy, it’s the default human condition for most I think, but I always get the job done by any means that are needed … like swimming over here at the moment during winter in an outdoor heated pool while it is raining … it’s better than it sounds, as it’s warmer in the pool than out, and you virtually have the pool to yourself.
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂[video]http://https://www.youtube.com/watch?v=civzfZ_3uVc[/video]
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Sven
Very encouraging signs … you should be confident that the DAAs are working their magic and you’re on your way to SVR.
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Fitz wrote:
Just received my 6 week results by telephone. “Non-quantifiable <15"Hi Fitz
Great results ... I bet that made you forget about your nose for the rest of the day ... until you brushed your teeth before bed that is.
You'll get another spring in your step when it comes in the mail and you see it printed on a piece of paper ... for some reason, I did anyway.
It makes my day when I see others get quick results from these demonised DAAs ...
Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Gaj wrote:
Good luck with the diet and excercise, neither of which are really at the top of my list of “things I’d rather be doing”
Hi Gaj
Diet & exercise is way down towards the bottom of the list of things that I’d rather be doing, however, I was advised that it should be my main priority during treatment. As it turns out, I’m thankful that I followed this advice because of the health benefits I am now enjoying.
Hopefully I will achieve SVR24 and after that I will revert to living a normal life, enjoying and savouring all of its fruits on offer, but in the interim will continue living with my list of things that I’d rather be doing being inverted on it’s head. It’s only for a few months, and 6 months in total, so not long in the scheme of things considering the many future years that I plan to enjoy life at its fullest.
Maybe you should, with all respects, re-think your priorities.
I’m a former amateur boxer in my youth and rationalised my training before, during, and after treatment as being as fit as possible for my fight with HCV. Its down for the count and it didn’t lay a glove on me.
Respectfully
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Beaches
You’re coming off a very easy and gentle treatment because, in my opinion, you did everything that a doctor could wish their patient do during treatment by doing daily exercise and eating well.
I want to thank you for inspiring me to get back into the pool and swim laps. I’m swimming 30 laps of a 50m pool, roughly what you swim in the open water at Manly, on average 5 days a week. After buying my Accu-Chek blood glucose meter, I quickly realised that swimming is the exercise that best lowers my blood glucose, as it’s a whole body exercise combining aerobic and resistance training.
So there’s a tip for anyone wanting to lower their blood glucose – take up swimming.
I’m happy as a pig in a peach orchard.
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Beaches
Don’t worry about the 1 percenters … it will give you ulcers.
The currently available evidence suggests the following:
SVR (Sustained Virological Response)
Treatment success rate is about 90-95% and is measured with SVR. SVR is counted in weeks from the cessation of medication.
• SVR24 is the gold standard – zero viral load at 24 weeks post treatment and represents a < 1% chance of ever seeing the virus again. • SVR4 represents a 97% chance of making SVR24 (96% chance of cure) • SVR12 represents a 99.7% chance of making SVR24 (99% chance of cure) See: http://fixhepc.com/kunena-2015-11-10/gp-cheat-sheet.htmlIf these figures are incorrect, then they need to be updated.
As far as I'm concerned, that constitutes a "cure" in my books.
Even a pessimist should be happy with those odds.
You can argue the semantics of "cure" until the cows come home ... but, this may put others off treatment because doubt has been cast as to weather or not they will be 'cured' of HCV. I simply wish that anyone with HCV can get timely access to generic DAAs and experience a new lease on life like I have ... and I haven't even achieved SVR yet.
The take home message is that if you achieve SVR24, there is less than 1% chance of ever having HCV RNA detected again. Pure and simple. Dr Freeman has provided these numbers, so I am confident that they are correct, as they have been published in peer reviewed journals.
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Price wrote:
Oh come on, my answers weren’t that bad.
PI’ll let others be the judge of that by letting the read the following answer that you gave me:
Post #17625
Price wrote:
The product monograph for Sovaldi (page 12) lists 6% blood sugar >250 (13.9). That’s diabetes but they don’t list diabetes. It also lists fungal infections (page 10). There are actually quite a few side effects that are not listed on the medication insert.http://www.gilead.ca/pdf/ca/sovaldi_pm_english.pdf
Things like palpitations, chest pain, visual impairment, basal cell carcinoma and amaurosis fugax (a transient monocular or binocular vision loss that appears as a “curtain coming down vertically into the field of vision in one eye;”
That sounds just like a detached retina. One of our Vets had a detached retina while on Harvoni.
The Harvoni monograph lists blood sugar >160 (8.9) in 9% for the 8 week group, 10% for the 12 week group and 12% for the 24 week group.
Again, a fasting blood sugar of 160 is diabetes but they don’t list diabetes or say whether it resolved.P
Post #17628
Gaj wrote
I agree it is important that people understand that any drug treatment has some risks attached to it. However to avoid unnecessarily alarming those seeking or undergoing treatment we need to be mindful of how significant those risks are and careful to explain what the actual figures mean.The “fungal infections” is listed in a group of side effects that are present in less than 3% of trial subjects and in all instances of these trials the Sovaldi was used in combination with Ribavirin +/- Interferon. It may still be applicable to members and guests of this site even if few are using these combinations but there is absolutely no evidence presented in the attached documents to confirm that.
The “6% blood sugar >250 (13.9)” is in one arm of the trials and is at least three times the levels of the other four arms. That particular arm is marked as PBO . So I checked what that meant and page 8 states “71 subjects who received placebo (PBO) for 12 weeks.”
Retinal detachment is a known risk associated with Peg/Riba treatment, to the extent that I was required to have an eye exam prior to participation in a clinical trial where I would receive that combination. Do you have any evidence to support its occurrence when using DAAs only?
See:
http://fixhepc.com/forum/experts-corner/1063-thrush-and-or-thirst-check-for-diabetes.html?start=15
No evidence was provided … still waiting ….
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Hi Gaj
Your comments are duly noted.
I have misunderstood the main objective of this forum. I innocently thought that it was to provide up to date information about the availability and access to generic HCV medication and to offer support to those undertaking treatment that may be experiencing side effects. In any case, that is the benefit I have had from the forum. The warts and all discussion of Hep C, including the tedious semantics, I will leave to others. I sincerely hope that those that may be new to the forum, and are generally seeking treatment advice because their medical system as failed them to various degrees, are not baffled by all white noise.
Feel free to remove all of my posts on this thread.
Have a nice day.
Regards
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂London has finally had some sunshine for the first time this summer, according to news reports, so she is probably out making the most of it instead of sitting in front of a boring computer.
Rain is forecast for the weekend in London, so you’ll probably see her back here again then.
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂This thread has been hijacked by a discussion about the semantics of what defines HCV as a disease and whether SVR24 constitutes a cure.
It is easy to distinguish between those who have suffered from HCV and those who haven’t simply by the comments that they have posted. No HCV sufferer is interested in the semantics of whether SVR12 or SVR24 can be medically defined as a cure or not. We are only interested in regaining our health after suffering HCV for decades and suffering with all the associated health issues that HCV has caused.
I have had HCV GT2 for 33 years and completed a 12 week treatment of generic SOF + DCV on the 2 July 2016. I haven’t been officially “cured” of HCV as I’m still waiting for my SVR4 test, which theoretically will give me and indication to the degree of confidence of achieving SVR12 and SVR24. Time will tell whether I achieve SVR24 and some will tediously argue whether this constitutes a HCV cure. However, from my perspective, I can honestly state that I can’t remember feeling this healthy during my adult life. For those who propose that the best evidence suggests that most HCV sufferers could not benefit much from treatment is either highly ignorant of the facts or purposely misleading to serve an undisclosed hidden agenda.
The discussion about semantics and pragmatism illuminates why the opinions of marginalised health professionals sitting in their ivory towers arguing semantics, with little or no practical experience with HCV DAAs, should be ignored, and why the opinions of pragmatic doctors with a disclosed mission statement to globally eradicate HCV should be sought. Don’t be fooled by all the hogwash.
Dr Freeman has successfully treated many hundreds of patients with generic HCV DAA medication. Make an appointment with him to discuss your options. There is no need to unnecessarily suffer with HCV, and the associated health issues that it causes, when there are relatively inexpensive generic direct-acting antiviral medication that will ‘cure’ it.
Dr. Freeman can also be reached at gp2u.com.au/
or email admin@gp2u.com.au________________________________________________________________________________________________
Humpty Dumpty discusses semantics and pragmatics with Alice, in Lewis Carroll’s Through the Looking-Glass (1872)
“I don’t know what you mean by ‘glory,’ ” Alice said.
Humpty Dumpty smiled contemptuously. “Of course you don’t—till I tell you. I meant ‘there’s a nice knock-down argument for you!’ ”
“But ‘glory’ doesn’t mean ‘a nice knock-down argument’,” Alice objected.
“When I use a word,” Humpty Dumpty said, in rather a scornful tone, “it means just what I choose it to mean—neither more nor less.”
“The question is,” said Alice, “whether you can make words mean so many different things.”
“The question is,” said Humpty Dumpty, “which is to be master—that’s all.”Alice was too much puzzled to say anything, so after a minute Humpty Dumpty began again. “They’ve a temper, some of them—particularly verbs, they’re the proudest—adjectives you can do anything with, but not verbs—however, I can manage the whole lot! Impenetrability! That’s what I say!”
_______________________________________________________________________________________________________Choose your own path … and don’t be mislead by others with undisclosed hidden agendas.
Let’s eradicate HCV.
Cheers
GT2
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂illy:' /> illy:' /> illy:' />
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂[video]http://https://www.youtube.com/watch?v=PdLIerfXuZ4[/video]
[video]http://https://www.youtube.com/watch?v=ZgubG-MOPT4[/video]
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂Attachments:
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂“The question is,” said Alice, “whether you can make words mean so many different things.”
“The question is,” said Humpty Dumpty, “which is to be master—that’s all.”
Humpty appears in Lewis Carroll’s Through the Looking-Glass (1872), where he discusses semantics and pragmatics with Alice
1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
09/05/16: ALT 34, VL: NOT Detected 🙂 , FBG 11.9
17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂 -
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