Looking for treatment advices

This topic has 9 replies, 6 voices, and was last updated 9 years, 1 month ago by LondonGirl.

Viewing 10 posts - 1 through 10 (of 10 total)

Author

Posts
9 October 2015 at 7:53 am #2063
zzhou
- Topics: 1
- Replies: 3
- Total: 4
- Novice
@zzhou
My mother in law is living in Beijing China, 78 years old. She was infected with HCV genotype 1b from blood transfusion due to a surgery at hospital in early 80s. Her situation is pretty bad right now, decompensated cirrhosis, CTP-C, also has oesophageal varices which causing internal bleeding in Feb 2015. Is it safe for her to take new DAAs to treat Hcv at this stage? Any successful cases like her? Which combo – SOF/DAC or SOF/LED is best in her situation?
Thanks
9 October 2015 at 2:56 pm #2072
Dr James
- Topics: 264
- Replies: 1,968
- Total: 2,232
- Guardian Angel
@fixhepc
24 weeks of Sof/Dac or Sof/Led would help. No Riba.

My impression is that Sof/Led might have a slight side effect edge so may be more gentle. Both are gentle treatments.

The typical treatment experience is feeling better than for years within a week of starting.

It is hard to say how many years of life it might add, but those years may well be better.

It would certainly be worth giving 12 weeks to start and then next 12 if that goes well.

If you need help with sourcing Buyers Club can help and price is less for delivery in China because that is source country. You could probably have delivered on Monday.

YMMV
9 October 2015 at 4:38 pm #2074
zzhou
- Topics: 1
- Replies: 3
- Total: 4
- Novice
@zzhou
Thank you Dr Freeman for the advice.

Dr Freeman, do you happen in contact with any Chinese doctor in Beijing are familiar with those new treatments and willing to write prescription for generic and follow up monitoring? Apprantly, same as many other places, we have not found any doctor is willing to do so. One of the doctor she was seeing suggested Sof/Riba combination for 12 weeks which is not recommended to my understanding.

I was think about API when I learned it here and Greg’s blog, however, we could not find anyone in Beijing willing to compound. DIY is not possible considering their age and conditions, we are living in Canada and could not help much with that. For the moment, I am trying to source twinvir, if not successful, then we will fail back to APIs.

Thanks again!
9 October 2015 at 5:07 pm #2075
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
The doc is right.

You can use twinvir. It is for type 1.

I am type 1a and I am going to use that
9 October 2015 at 5:42 pm #2076
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Hi Dr F and tweak max, Do you feel the Sofo/Led may be a little more gentle for most? I’m also GT1a and trying to decide. Does the How do DAC and LED differ ? Thanks

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
9 October 2015 at 6:27 pm #2077
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
Hi London girl,

I will let u know the side effects once I start (hopefully soon)

What did ur doc recommend u?

After reading so many articles, I think if u can get your hands on either sof + dac or sof + led, just use either combination.
9 October 2015 at 7:16 pm #2080
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Hi TM, My Dr hasn’t recommended me anything – I am in England
I will ask at next appointment.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
9 October 2015 at 8:11 pm #2081
wilko johnson
- Topics: 5
- Replies: 47
- Total: 52
- Recovery Champion
@wilko-johnson
hi LG,have a read of EASL HCV TREATMENT GUIDELINES 2015 SUMMARY.its a very clear and consise bit of info.sorry dont know how to do a link.

gt3 started sof dac jan 2016 now 48 wks svr. not the real wilko johnson just have the same real name. shropshire uk
9 October 2015 at 8:25 pm #2082
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
Do you have any info about twinvir and its effectiviness?

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
10 October 2015 at 12:43 am #2088
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Thank-you Wilko, will revisit, have been waiting for Harvoni, but now there is the Sofo/DAC option.

Engle, I do hope you can get sorted out to help your Mother, God bless her.

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
Author

Posts

Viewing 10 posts - 1 through 10 (of 10 total)

You must be logged in to reply to this topic.