24 week Sof, Led with 12 week Riba

This topic has 55 replies, 14 voices, and was last updated 8 years, 10 months ago by Hamilton-Gray-facebook.

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25 October 2015 at 5:34 am #2696
Hamilton-Gray-facebook
- Topics: 6
- Replies: 29
- Total: 35
- Treatment Warrior
@hamilton-gray-facebook
Hi all ,
I’ve just started my treatment 4 days ago.
Only early days but no side effects to date.
Is there anyone on here doing this same treatment ?

Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL – negative at 12 weeks
25 October 2015 at 6:59 am #2698
tweakmax
- Topics: 18
- Replies: 238
- Total: 256
- Guardian Angel
@tweakmax
Wow u started! Great!

I still waiting for my twinvir
25 October 2015 at 7:35 am #2705
miko3
- Topics: 5
- Replies: 82
- Total: 87
- Guardian Angel
@miko3
Hamilton— Don’t get it.What is the logic behind 24wks sof led,and only 12wks riba.Curious!

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
25 October 2015 at 8:04 am #2706
Hamilton-Gray-facebook
- Topics: 6
- Replies: 29
- Total: 35
- Treatment Warrior
@hamilton-gray-facebook
I’m geno type 1a, treatment experienced, fibrosis 3-4 bridging cirrhosis .
So being Gt1a is 24 weeks & early cirrhosis my doctor told me to be sure to be sure, we’ve included 12 weeks of Ribavirin

Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL – negative at 12 weeks
25 October 2015 at 8:21 am #2707
Hamilton-Gray-facebook
- Topics: 6
- Replies: 29
- Total: 35
- Treatment Warrior
@hamilton-gray-facebook
So where is the Twinvir coming from ?
Are you doing your own importing or is it through Greg geofferey ?
Is Twinvir Sof & Dac ?

Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL – negative at 12 weeks
25 October 2015 at 9:56 am #2712
miko3
- Topics: 5
- Replies: 82
- Total: 87
- Guardian Angel
@miko3
Twinvir is Sofosbuvir plus ledispavir,ie Harvoni.
I am on sof plus declatasvir plus riba.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
25 October 2015 at 11:27 am #2713
Hamilton-Gray-facebook
- Topics: 6
- Replies: 29
- Total: 35
- Treatment Warrior
@hamilton-gray-facebook
Miko 3 , what is your geno, fibrosis , past treatment ?

Male aged 66, contracted hepC 45 years ago
Failed treatment interferon and Ribavarin 2003
Started treatment 22 October 2015, 24 week, Dr Freeman
Sofosbuvir and Ledisbovir plus 12 weeks Ribavirin
Geno 1a
Fibrosis F3/4
VL <12 at 4 weeks
VL – negative at 12 weeks
25 October 2015 at 12:23 pm #2715
miko3
- Topics: 5
- Replies: 82
- Total: 87
- Guardian Angel
@miko3
I am 1b,treatment naive,vl off the scale,enzymes not far above top of normal range,positive for, as far as I can quess ,38yrs ,fibroscan 14.1.fibrosis unknown but assumed to be f3/f4.no sign of cirrohsis when ultrasound done 3yrs ago . when I was told to wait,but probably there now.3 wks into tx with no side effects worth mentioning,and feeling better than I have for donks.I can really feel this stuff killing off the virus day by day.Cant wait to see what the 4wk test results produce.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
25 October 2015 at 12:34 pm #2716
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Hi Miko, Do you mind me asking, are you well-built? It would be interesting to know which patients have no/more side effects according to weight, although I understand that not all may wish to share, but I would find it interesting as I am very tiny. LG

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
25 October 2015 at 3:29 pm #2722
miko3
- Topics: 5
- Replies: 82
- Total: 87
- Guardian Angel
@miko3
London Girl,Im 70kg5’9″ slim and like to think I”m very fit,which I’m determined to maintain,whatever,and which I think is the real key as to why my journey so far has been easy.I know a lot of you out there are suffering.I just keep telling myself every time I down some of those pills I hear the dying virus scream in rage.Its been said before on these forums that except for riba,dosages are one size fits all.Probably as more and more info on dosages appears that will change.But that is Dr Freemans area of expertise.

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
25 October 2015 at 3:34 pm #2723
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Hi Miko, thanks for that, It is very interesting to me and I feel of interest to others here too, possibly in paticular female patients.

You are 6′ 9″ ? -Smiles, I am 5′ 2″

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
25 October 2015 at 3:35 pm #2724
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
Doing my own little ‘research ‘ here

So if anyone would like to PM me their height, build, weight & sides if they don’t want them on the forum for public scrutiny, please feel free

Ps Alsdad has a separate thred on here ‘weight & patient dosing’

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
25 October 2015 at 3:44 pm #2726
miko3
- Topics: 5
- Replies: 82
- Total: 87
- Guardian Angel
@miko3
Sorry London Girl,I made a typo,I’m actually only 5’9″

Gen 1b 40yrs,tx naive, f3/f4.VL too high to quantify.
Started tx 12Oct.sof and riba India via greg.Dac from Mesochem.
4wk result virus not detected,all liver functions in normal ranges.
Only SE intermittent insomnia.Feel great and grateful otherwise
25 October 2015 at 3:51 pm #2727
LondonGirl
- Topics: 16
- Replies: 1,348
- Total: 1,364
- Guardian Angel
@londongirl
He he I did wonder, thought you were joining the ‘Too damn skinny club’ along with me for a min

GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 ‘In the slow lane’
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC
26 October 2015 at 6:32 am #2758
emilio
- Topics: 13
- Replies: 368
- Total: 381
- Guardian Angel
@emilio
Hi Hamilton

We tried to chat the other day but the system was clunky. I’m emilio, geno 1b and currently day 20 of sof/dac and only doing 12 weeks at this stage. F2/3 approximate. Treated before with IFN/Riba and polymerase inhibitor in 2008 for 63 weeks. While F3/4 doesn’t quite make you cirrhotic it’s getting up there and I can see the need to hit this longer and harder maybe. What’s your VL? starting. I was considering extending to 24 weeks but will make that decision in a week or so, just see how my body responds. In regard to the ribavirin, if it were me I wouldn’t use again as a geno 1 but I do see the benefits in leading out with Rbv and leading in for that matter. I believe riba is still a must with geno 3 and moderate damage and extension. Em
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