It looks like the reason for shortening treatment is to save money. With generics this is much less of an issue. Doing a bit longer makes sense for many of us.
The 8 week course for Mavyret now is pretty quick! We used to do a year.
It is a shame you are having so many side effects, it does happen but is fairly uncommon.
Timing the meds, drinking a lot of water, going for a daily walk, eating well, those good routine habits seem to help. I hope it is over quickly for you and you feel better soon.

Keep in mind tototo,that study you were looking at is still in it’s infancy looking to see if duration can be shortened for some.
Who knows, maybe someday this will be the case, but for now the recommended dose is the only way to go, so hang in there.
If you are doing 8 wks. ,Iguess only about 4 to go.

Yes, drink lots of water,Idid 16wks. this last go around and found the water intake helped immensely.
Be over before you know it!

Hello tototo,

For any of the DAA medications the cure rate looks like this:

Below 4 weeks there is virtually no cure rate. This relates to the 1/2 life of the replicon being around 4 weeks so you need to “keep killing” it for at least this long otherwise it will recover.

Then on the far right you see the reality. Every extra week of treatment adds a little more to the cure rate, but each extra week adds less than the previous one.

We know that for any patient who is cured we were giving them drugs for at least one day, maybe one week, maybe one month too long but we have to strike a balance between cure rate and duration and our tests are not sensitive enough to detect cure.

For Harvoni the cure rate @ 8 weeks is ~90% and 12 weeks is 95% – that’s from the VA data not the Gilead company data. Most of our retreatment cases got only 8 weeks Harvoni.

Maviret is good and the 8 week treatment should give you a ~95% chance of cure. Longer would be nice but you probably just have to chance it at this stage as at day 24 you’re almost 1/2 way through. The odds are 20:1 in your favour.

Hi Tototo,

I just want to chime in here for your benefit. I really hope the Marivet works for you.

If it does not, please contact Dr. James here. He will prescribe other medications and help you to be cured.

He can help you obtain generic medications that are the equivalent Harvoni/Epclusa or Marivet. He is the leading expert on the treatment of Hep C. I took generic Harvoni and I am close to 3 years now being cured.