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  • 24 December 2015 at 3:42 pm #7239
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Background:

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754513/

    Folic acid and vitamin B12 deficiencies develop frequently in patients with cirrhosis. These deficiencies may be related to inadequate food intake or intestinal malabsorption.

    Although it’s old research I only recently (5 minutes ago) came across this:

    http://hepatitiscnewdrugresearch.com/vitamin-b12-supplements-may-help-treat-hepatitis.html

    Take Home Message:

    If your B12 is low you should have an injection of B12 – higher B12 levels were associated with better SVR rates in the Interferon Riba days and that may well still be true.

    Note: While an injection of B12 is the fastest way to get your levels up it can be taken as tablets.

    YMMV

    25 December 2015 at 2:48 pm #7279
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    That’s really interesting. When I was in hospital this year in Thailand with dengue fever, B6/B12 tablets were the only medication they gave me apart from stuff to alleviate symptoms.
    I might get some. Not injections though. Ewww.

    This would be particularly important for vegetarians as there are no reliable vegetable sources of B12.
    https://umm.edu/health/medical/ency/articles/vitamin-b12

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    26 December 2015 at 4:41 am #7315
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Interesting question. I’ve been a vegetarian since about 1985 and have been taking B12 supplements for a while. Just noticed on a blood test result a few weeks back I now have it in excessive levels – about 100 pmol past the maximum :blink: No idea what that means lol

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    26 December 2015 at 5:17 am #7323
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    I guess it means you will have expensive piss. :) Can you take a bit less?

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    26 December 2015 at 8:58 am #7326
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Hmm guess so sonix :lol:

    Yeah I gave them away after I saw those results, pending some more advice from my GP, II was only taking one per day as it was.

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    26 December 2015 at 9:03 am #7327
    Avatar photoTina-Hill-facebook
    • Guardian Angel
    • ★★★★★
    @tina-hill-facebook

    Its all that spinach Zhuk.

    SVR 24

    26 December 2015 at 9:04 am #7328
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Damn, Tina!

    :blink:

    I think you might be right :lol:

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    26 December 2015 at 12:22 pm #7329
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    Hi Sonix. Dengue Fever? I’ve read about it, don’t know anybody personally (yet) whose had it, but its been creeping northward in the US due to climbing temps, been showing up in Florida….I heard its bad….so how bad was it? I’m assuming if you were in the hospital, it must have been pretty damned bad…

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    26 December 2015 at 8:48 pm #7338
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    I don’t recommend it. Every muscle aches, fever, headache, loose bowels, skin rash, and I only had a mild case. If it progresses to dengue haemorrhagic fever you can get bleeding sores on your skin. Platelet levels got pretty low and the travel insurance medicos wouldn’t let me leave hospital till they started rising. 8 days in hospital in Trang. Was very fatigued for a couple of months after returning to Australia.
    Be careful of mosquitoes!

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    26 December 2015 at 9:12 pm #7339
    Avatar photoEnkel
    • Guardian Angel
    • ★★★★★
    @enkel

    Methylcobalamin B-12 1000 mcg MicroLingual, just put under the tongue and have no sides. Better than shots.

    Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
    Started Twinvir 12/12/15.
    Two weeks
    ALT 17 at 2 weeks
    Viral Load UND at 2 weeks
    ALT 13.5 at 7 weeks EOT
    ALT 10.5 at 15 weeks EOT
    ALT 13 at 27 weeks EOT, VL UND, Cured

    27 December 2015 at 4:33 am #7361
    Avatar photodointime
    • Guardian Angel
    • ★★★★★
    @dointime

    I got that b12 for under the tongue a few years ago. After using it for some weeks my lower front teeth got painfully sensitive. These particular tablets had some kind of fruit flavour which was acidic and leached the enamel on my teeth. I had to use an enamel repair toothpaste for a while to get rid of the tooth sensitivity.

    dt

    1 January 2016 at 11:30 am #7694
    Avatar photoPrice
    • Guardian Angel
    • ★★★★★
    @price

    Hep C patients are known for having low B Vits and interferon also lowers them

    http://www.ncbi.nlm.nih.gov/pubmed/19042060

    Plus you need B vitamins to shift the transmethylation pathway towards producing glutathione

    to reverse the effects of HCV on Jak-STAT signaling pathway and restore STAT1 methylation you need SamE, Betaine, Vit B12, B6, and Folate because they are cofactors.

    A study showed that adding SamE and Betaine increased RVR.

    P

    1 January 2016 at 1:22 pm #7700
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    Hey sonix, interesting – I am low & don’t eat red meat.

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    1 January 2016 at 1:39 pm #7702
    Avatar photosonix
    • Guardian Angel
    • ★★★★★
    @sonix

    I’ve been taking Jeunesse AM & PM Essentials nutrients for a couple of months and definitely felt better even before Tx. They contain a decent amount of B6 and B12 plus about a million other things to make you younger and healthier.
    The PM ones help you get to sleep but I still have trouble staying asleep for long enough.
    They’re pretty spendy but I’ve ditched all other supplements apart from small amounts of magnesium and silica. I also only take one of each a day instead of the recommended two. I actually get them from my osteopath for wholesale price. They have a “preferred customer” plan that will save a bundle too.
    And no, I’m not associated with the company. :)

    M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
    SVR4 at 7Apr16 ALT 22 AST 22
    SVR12 at 9Jun16 ALT 23 AST 25
    Melbourne, Australia

    1 January 2016 at 3:41 pm #7715
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Yeast spreads such as Marmite do have added B vitamins including B12 and folic acid.

    https://en.m.wikipedia.org/wiki/Marmite#Nutritional_information

    And for Aussies there is Reduced Salt Vegemite (normal Vegemite doesn’t have B12 added)

    https://www.vegemite.com.au/products/vegemite-reduced-salt

    Probably not enough if you are seriously deficient unless you eat them by the spoonful but will supplement to other sources.

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

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