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TOPIC: Need advise for gt4 treatment

Need advise for gt4 treatment 10 months 3 weeks ago #27472

  • beahavan
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My dental infection was a bacterial infection and I think that contributed to the slight increase in my ALT and AST in my last blood work. Sounds like you have a lot going on including your exercise routine. I am confident that your results will be good. I know it is hard but try and relax. Hopefully you will not have to wait long for your results. Remember that Genotype 4 is very sensitive to DDA's.
G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
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Need advise for gt4 treatment 10 months 3 weeks ago #27481

  • kaju
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Hi Beahavan,
Thank you for your positive reply. I want to believe this. I dont wake up tired and still I feel healty so hope all is fine and will reach svr24.
at the svr4 and svr12 my alt was high too. Maybe I have another issue but I want to first finish this.
Cheers
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Need advise for gt4 treatment 10 months 3 weeks ago #27497

  • kaju
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Firstly, wish Merry Christmas to everybody Hope you are having a great time with your family and beloved.

Second , MY test result is VIRAL GENOM NOT DEDECTED. I reached SVR24

Thnak you very much specially TO dear Dr. James and all other friends who reply my paranoid and unusual questions. You guys gave me very big motivation and positive feeling in my journey. Hope after six month I will be undedected again and everthing will be more clean.
Thank you very much guys. Everbody is awesome here..
Cheers and happy new year from now ..
Last Edit: 10 months 3 weeks ago by kaju.
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Need advise for gt4 treatment 10 months 3 weeks ago #27498

  • rightsaidfred
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Hello Kaju,

I'm very pleased to hear your news. You must be feeling really good about it. Perhaps you could afford to relax a bit now? I say this because you mention that you're looking forward to the next set of results but if your viral load is undetectable at 24 weeks it is almost completely certain that you are fixed. Dr James could give you the statistics which support what I am saying.

With all best wishes for a healthy 2019,

RSF
G3a. Probably infected 40 years ago.
Diagnosed July 2015
7/7/2015: ALP 69, ALT 209, WBC 5.8, VL 40,000. Fibroscan 9.5 Kpa.
Commenced treatment Sof/Dac (Natco Pharma) 24 wks in Feb 16
VL UND @ 4 wks, 12 wks

EOT 6/7/16
SVR 12
SVR 24

PHEW! Thank you so much Dr James, Monkmeds and all at Fixhepc
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Need advise for gt4 treatment 10 months 3 weeks ago #27499

  • Mar
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Congratulations Kaju !!! You can finally relax for sure now as rightsaidfred said, be happy, no more Hep C #woohoo!
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Need advise for gt4 treatment 10 months 3 weeks ago #27501

  • Songbird
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That’s great news Kaju and Congratulations on being Hep C free!!

S
Diagnosed: 2001 GT1a , HCV since mid-70's.
Biopsy 2010 F1
Fibroscan and Fibrosure 2018 F2

Treated in trial 2010 with Dac/Peg/ Riba and Relapsed.

Resistance test 2017. Have Ns5a Rav Q30r/H58d enhanced from doing Dac.

Start Tx. Jan 18th/18 w/ Vosevi /Riba 12wks. plus 6 wks.Viekira Pak +Sof/Riba(From Dr Freeman @GP2U)

VL start: 1.6mill.ALT 125 AST 88
Wk. 4 Det @LLOQ <15.
VL Wk.8 UND Alt &Ast 22
Wk. 12 UND
EOT:UND

EOT+12 >>>UND (SVR12)! ALT11 AST13
Nov6/18 SVR 24!
Last Edit: 10 months 3 weeks ago by Songbird.
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Need advise for gt4 treatment 10 months 3 weeks ago #27503

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At SVR24 we are 99.99% certain there will be no relapse. The 1:10,000 who do relapse are suspected to be reinfections, rather than true late relapse cases.

This makes sense when you think about it. The incubation period for Hep C is 14-180 days. It only takes 1 week for the drugs to wash out of your body (1/128 level) which is below the therapeutic level. By 2 weeks there is only 1/16,348 the level on treatment. So after this time the virus (if there was any left) has, by SVR24 had a full 22 weeks to grow back unimpeded by the effect of the drugs.

It's logical that if it has not grown back by this stage then the reason is there was nothing left to grow back.
YMMV
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Need advise for gt4 treatment 10 months 2 weeks ago #27513

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Fantastic news!! Have a spectacular 2019. You have a whole new life waiting for you. Enjoy.
G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
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Need advise for gt4 treatment 10 months 2 weeks ago #27516

  • kaju
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Hi Guys,
Thank you very much for your good wishes
I am very happy and this is like kind of magic.
When I look the past ıt has been almost 2 years and now ı can not believe ı am hep free :)
All you guys are awesome and gave me very good positive feeling and motivation.
Sometimes I felt bad and pessimistic but your msgs always give me hope ..
I was alone with the hepc every single day it s like kind of my dirty secret and always feel press on my shoulder.Every morning and night. Before sleep and after get up. Always in my mind.I know how I get this and this is bad seal from past.but now we beat it. I am very happy and feel free.
Thank you very much guys and again especially thank you very much Dr James.
I will try my best for help the people in my country who needs treatment. Medicine are quite expensive and lots of people doesnt know here. wish you a great day and happy new year...
Cheers.
Last Edit: 10 months 2 weeks ago by kaju.
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Need advise for gt4 treatment 10 months 2 weeks ago #27521

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Hi Kaju,

Please let me add my congratulations. :woohoo: :woohoo:

I know what you mean about it being a bit like magic when you have carried the burden of Hep C for years and then it is gone.....

Spreading the word is a great way for us all to pay our good fortune forward. Best wishes for 2019 and onward.

Coral
G1a probably early 1980's, Biopsy F1(2010), F2-F3(2015). VL 5+mill; 2+mill (2014) Tx naive. Accessed Sof/Led through Dr Freeman at GP2U and Buyers Club (lifesavers!!!)
Commenced tx 12/11/15. 9 wk: VL <15 Detected but LFT = Normal 12 week results: UND (Yay!) Due to slow response commenced Sof/Dac 4 Feb for 12 weeks. EOT @ 24 weeks 27 April 2016. (With thanks to Dr Freeman et al). SVR11 result: VL 1,950,000. It's back!
New tx 030916 (Viekira Pak, Solvadi, Ribavirin UND @ 111116. EOT 170217.
SVR12 and SVR 24...
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Need advise for gt4 treatment 5 months 3 weeks ago #27868

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Thank you Carol :)
Almost 6 months after svr24 , time is came for last test
Hope all will be fine again
Cheers
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Need advise for gt4 treatment 5 months 2 weeks ago #27869

  • beahavan
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The time has gone quickly. Looking forward to hearing your good results.
G4
F0-F1
diagnosed in 2006
Tx naive
Treatment started 8/12/16, Ledipasvir/ Sofosbuvir (Harvoni) supplied by Monkmed
8/1/16 ALT 36 AST 40
1/4/17 ALT 17 AST 21
7/13/17 ALT 17 AST 25
12/28/17 ALT 22 AST26
2/22/18 ALT 19 AST 25
7/10/18 ALT 26 AST 32
1/8/19 ALT 16 AST 28
7/2/19 ALT 16 AST 26
Hcv Rna, Quantitative Real Time Pcr <15 NOT DETECTED (IU/mL) NOT DETECTED
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Need advise for gt4 treatment 5 months 2 weeks ago #27872

  • DrJames
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Hello Kaju,

I'm sure everything will be fine.

Best Regards

James
YMMV
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Need advise for gt4 treatment 3 months 2 weeks ago #27981

  • kaju
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Hi Guys,
Few days ago I received my last hcv rna result and after 1 year still UNDEDECTED.

I am very happy for share this with you guys :cheer:


If anybody experince with hepatit b booster shot could you please help me abut my concerns.

I decided to get booster shot for hepatit B .

I already got my second dose.

Normall procedure is ; total 3 dose. 1 month, 2dn month and 6th month

But doctor told me they want to give me last dose on 7th month. They think it will be more succesfull.
Also I am wondering is it not possible to got hepatitb from booster shot right? After hepatit c I become paranoid.

Again, thank you very much to everybody to support me in my journey. Thank you guys.
Cheers.
Last Edit: 3 months 2 weeks ago by kaju.
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Need advise for gt4 treatment 3 months 2 weeks ago #27984

  • DrJames
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Hello kaju,

Congratulations on your SVR52.

It will not matter if you have 3rd dose for Hep B at 5,6 or 7 months.
YMMV
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