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6 years 9 months ago #2184

LG she has adjusted well after some sides the first few days. Getting better as it.goes which is great.

So an 80_90 kg male could do 625mg sof and 135mg dac comfortably, i think? Em


Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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6 years 9 months ago #2185

Might be an option for someone with a high level of fibrosis or cirrhosis. I know the higher doses were trialled, up to a week if I remember correctly. I'm 95kg (no comments please, I get enough from my wife!) and F0 fibrosis, and the standard dose is working fine for me.

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6 years 9 months ago #2186

'some sides' ? 'a little flu-like'? ;-) good to know things are getting better for your friend.
Interesting though, dose adjustments, so is it not so much length of time as dose then?
does high dose over short time = low dose over longer time ?


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 9 months ago #2187

Hi AD, weight, fibrosis or geno based, maybe? If specialists, GPs start tinkering with this they may punch out a few more.percentage points in revard to clearance rates? These drugs wont be around longn enough, in my opinikn. Theyr already looking at 1 shot experimentals that are getting the same clearances rates. Em


Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.
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6 years 9 months ago #2196

Interesting question re weight and dosage, thanks for the feedback everybody. I'm 53kg and 5'7" so in that lightweight category: talking with Dr Freeman yesterday he suggested a possible slight drop in dosage for daclatasvir at least until a bit of tolerance had been reached might be needed - of course eveyone's individual mileage may vary when it comes to personal side effect response. Will have to judge it when the time comes :)


GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26

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6 years 9 months ago #2199

How do you make a 'slight drop' ? Saw a bit off the end of the tablet? !


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 9 months ago #2200

LondonGirl wrote:

How do you make a 'slight drop' ? Saw a bit off the end of the tablet? !

Maybe take the meds 28 hours apart at first .


Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV
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6 years 9 months ago #2213

That does seem like a very reasonable way to go about it, rather than trying to titrate the dose down Paul...which is gonna be an inexact science heh Cheers for the suggestion!


GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26
Last Edit: 6 years 9 months ago by zhuk.

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6 years 9 months ago #2237

It's just a suggestion that I would want to run past a doctor first though zhuk.

cheers


Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV

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6 years 9 months ago #2238

Sure Paul, will do. I should have my first GP consult sometime tomorrow, I've only let her know about treatment in a brief phone message. Both of us have got a bit of time to get up to speed though...a lot to take in :)


GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 - 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 - 6 weeks UNDETECTED
AST 26
ALT 26

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6 years 9 months ago #2652

Hi everyome

On the road with limited communication in remote area. My 4 week RNA still detected under 15. No RVR for me, anyway ill give this fucker 24 weeks and see if it wants to stay around. Disappointed but confident of cure. Em


Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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6 years 9 months ago #2653

Bummer Emilio hopefully next time up it's gone, we both might be chasing some Riba yet !


Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated :):):)

GT 3 - about 28 yrs with HCV

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6 years 9 months ago #2660

Only 4 weeks in Emilio, less than 15 good and apparently tests can often detect dead virus'

On another subject, you seem to be very busy? Hope you're not overdoing things and getting enough rest / sleep?
Your liver would like that you know :)


GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

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6 years 9 months ago #2680

Hi Em,

Here's slides on resistance data.
www.clinicaloptions.com/Hepatitis/Treatm...sistance_Slides.aspx

They show that for people who do have NS5A resistant variants, the 24 week tx is the one that does the job more or less 100%. The 12 weeks is good but not 100%. So just in case you have some of these fuckers that just don't want to lie down and die, I think you are good with 24 weeks.

dt

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6 years 9 months ago #2682

Indeed! Encouriging post!

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