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Emilio's Place 7 years 2 weeks ago #2683

Furthermore - we all know that a successful tx is not about the millions of virions that go down in the first few weeks, it is about eliminating the few hangers-on that are left.

I watched that video on ribavirin resistance a ton of times and I am not convinced that ribavirin resistance makes it not worth while to use. On the contrary, there is data from the ION2 and the SIRIUS trials that show that it makes a difference in some situations. My thinking is that a DAA is a one trick pony. It has one method of action. If a virion mutation is not susceptible to that action then you can swamp it with that DAA till the cows come home and that mutation will just keep replicating and repopulate your viral load. Ribavirin, on the other hand, has more than one method of action. It is not as fast or dramatic as a DAA but it can still nail that mutant virion when the other DAAs have become useless. Which is exactly what you need to keep the pressure on when you have a few stragglers that just keep hanging on. So, in my humble opinion, I think that the role of ribavirin when used with the DAAs is underrated.

dt
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Emilio's Place 7 years 2 weeks ago #2684

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How about Asunaprevir? Could this be added to the mix?
Virus not detected from 14.10.2015
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Emilio's Place 7 years 2 weeks ago #2687

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Huhmn think so DT!

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Emilio's Place 7 years 2 weeks ago #2688

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Good post. Think so too is what I meant...

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Emilio's Place 7 years 2 weeks ago #2694

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Plenty of time for you to get to UND yet Em. Some don't get there until 9 or 10 weeks into a 12 week treatment and still achieve SVR.

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Emilio's Place 7 years 2 weeks ago #2700

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hi Em,
Yes, I'd be a bit upset too, at the same time your liver functions & other blood tests were very good, so I believe it is only a matter of waiting a bit longer for SVR. :)
As you said you could have F3 fibrosis & also you're tx experienced, I'm in the same situation, so due to this we probably need longer then 12 weeks tx & even add Riba at some point?
I was wondering if one can add Riba half way through the tx ? to assure best results ?
jolie xxxxx
Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA - UND. - down from 2 ML
9 weeks HCV PCR RNA - UND.

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Last edit: by Jolie.

Emilio's Place 7 years 2 weeks ago #2708

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Thanks for the well wishes and encouragement everyone. The long way round is okay with me. Riba? I'm still not sold on it for geno 1s? However would be keen on adding simprevir if anyone knows where. Em
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Emilio's Place 7 years 2 weeks ago #2709

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Last edit: by klhilde.

Emilio's Place 7 years 2 weeks ago #2710

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Thanks mate
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Emilio's Place 7 years 2 weeks ago #2711

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Em, Simeprevir is already on the PBS.
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.

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Emilio's Place 7 years 2 weeks ago #2712

Jolie -there was somebody on medhelp who added riba for the last 15 weeks of her 24 week tx. She got to SVR.
dt
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Emilio's Place 7 years 2 weeks ago #2714

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Thanks Joy, so throw away the interferon and keep the riba and simp lol, that could work?
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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Emilio's Place 7 years 2 weeks ago #2715

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Is it really as simple as buying API on Alibaba ?
There is one API I have my sight on for geno 3 to add to the mix sold in China, I mean is that all it takes ?
I did check the company looks very big & reputable making medicinal API.s

Because if it is as simple anyone can make their own meds.....& mix anything they like
Geno 3, Fibro 8.7 pKA, tx experinced in 2005 - Peg/Riba, relapsed.
Started tx 1/12/2015 with Indian Sofo & Chinese Dac.
5 weeks result all normal, ALT 18 - down from ALT 73 at the start of tx.
5 weeks HCV PCR RNA - UND. - down from 2 ML
9 weeks HCV PCR RNA - UND.

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Emilio's Place 7 years 2 weeks ago #2718

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You mean it only comes as a threesome? :blink:
NSW Australia. Genotype 1b 30+ years, F0-F1, VL 91,000 Feb 2015 (740,000 in 2010), Tx naive.
Ordered Sof/Dac from Buyers Club 21 Sept, received 14 Oct.
Virus UNDETECTED at 3 weeks AND 12 weeks (EOT) AND SVR4 AND SVR12 AND SVR24. :-)
A thousand thankyous to Dr James and the amazing FixHepC team.

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Emilio's Place 7 years 2 weeks ago #2721

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I think so Joy so approved with IFN/Riba as a tripple. Think i could take great pleasure smashing the ampules of IFN lol. Dont think you can obtain or buy separately
Geno 1b F2/3 snce early 80s. Treated in 2008_9 for 63 weeks on INF/Riba. Commence Sof/Dac on 6 October 2015 and completed 18 weeks of tx. UND at 4-6 weeks, UND at EOT, SVR 2, SVR 6 and SVR 12 on 6 May 2016.

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