Home › Forums › Main Forum › Genotype Specific › Genotype 3 (37%) › Any other geno 3, F4’s doing/done treatment?

Viewing 15 posts - 31 through 45 (of 53 total)
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  • 20 December 2015 at 1:16 am #6747
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Is definitely a type of chemo fox, has been used to treat melanomas and has been trialled with other cancers.

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    21 December 2015 at 2:29 am #6848
    Browny
    • Topics: 2
    • Replies: 13
    • Total: 15
    • Acolyte
    • ★★
    @browny

    Browny here

    I got a great parcel in the mail at the end of last week and started treatment on the weekend. Feeling absolutely fine apart from a weird chemical smell coming out of my body – will keep you posted on who the side effects and test outcomes.

    Great news about the PBS listing – so many people are waiting and dying for these drugs – I couldnt be more chuffed about it.

    Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
    Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

    12 February 2016 at 8:56 am #11775
    Browny
    • Topics: 2
    • Replies: 13
    • Total: 15
    • Acolyte
    • ★★
    @browny

    Browny here

    Updating progress following test results following 1 month on declatisvir and sofosbovir.

    Still detectable but viral loads are down from 5.8 Log 10 IU/ml to 1.2

    ALTs are down from 26 to 12

    Am experiencing tiredness and some nights with wakeful sleep but still going to work everyday. Also, still smelling very chemically.

    Am thinking of doing 16 weeks but am would love to hear from those who have new evidence showing that longer is better.

    Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
    Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

    12 February 2016 at 9:12 am #11776
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    What is the actual number of your viral load?

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    12 February 2016 at 9:17 am #11777
    Browny
    • Topics: 2
    • Replies: 13
    • Total: 15
    • Acolyte
    • ★★
    @browny

    Hec P RNA NAA was 6.4×10^5 and is now 15

    I don’t really understand the results very well …. (lol)!

    Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
    Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

    12 February 2016 at 9:20 am #11778
    Browny
    • Topics: 2
    • Replies: 13
    • Total: 15
    • Acolyte
    • ★★
    @browny

    this also should read hep c not hec P !!!!!!!!!!!!

    Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
    Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

    12 February 2016 at 9:26 am #11779
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    Is it <15, or 15? Thanks.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    12 February 2016 at 11:19 am #11787
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj
    Browny wrote:

    Hec P RNA NAA was 6.4×10^5 and is now 15

    I don’t really understand the results very well …. (lol)!

    Hi Browny,

    The log figure means the first number times ten by the number of times the little number beside the ten shows. So in your case 6.4 multiplied by ten, five times or 6.4 x 10 x 10 x 10 x10 x10 = 640,000 In other words, your pretreatment test was 640,000.

    I suspect your new result is probably less than 15, maybe shown as <15 just because 15 is a common cutoff point for a lot of these tests. Whichever it is, that's a good result for F3-4 at 4 weeks. :+1: :)

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    16 February 2016 at 7:09 am #11985
    Browny
    • Topics: 2
    • Replies: 13
    • Total: 15
    • Acolyte
    • ★★
    @browny

    Thanks Gaj and all

    I looked at the test result and it is just 15 (no < or >).

    I was a bit bummed at first because so many people on this site and the few people I know were undetectable after 4 weeks – but yes, the reduction in viral load and improvement in ALTs are all good.

    I just wanted to share my experience for others out there who might be in similar situations.

    Age 51 Genotype 3 since 1985, F3-F4, VL 5.3 (Nov), Tx naive.
    Ordered Sof/Dac from Buyers Club 16 Nov which arrived 17 Dec, started tx 20 Dec

    16 February 2016 at 11:51 am #11994
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    We have 33.5% cirrhosis patients in the group we are tracking. This is much higher than most of the published clinical trials.

    What we observe is that F3/F4 patients do take longer to reach undetected.

    In Gilead’s trials <25 was what was used so you would have been <25 detected, rather than 15 detected at 4 weeks, so it is in line with expectations.

    It will go to undetected, maybe through <15, but undetected should really read <10 or <8 because this is closer to the real meaning.

    With F4 GT3 you do need 24 weeks treatment to deliver a 90% SVR rate.

    Ketogenic diet, B12 and Vit D may assist, but that's speculative at the moment. The "energy slump" some patients get about a month into treatment does seem to respond to B-B-Berocca.

    I would not worry too much. It's not the millions of die easy HCV virions that cause relapse. It's the handful of resistant mutants that we simply can't measure.

    The observation of slower response does suggest why the extended treatment time is required for F4 GT3

    YMMV

    16 February 2016 at 12:45 pm #11997
    Avatar photoHazel
    • Guardian Angel
    • ★★★★★
    @hazel

    Hi,
    I’m geno 3 F4, I just got my VL back after 12 weeks tx- is under 15 but still detected- I have 24 weeks to take altogether and can see how important that is for those of us in this category.

    Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716

    17 February 2016 at 1:34 am #12025
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I just got my 4 week VL test back today. <15. :)

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    17 February 2016 at 12:31 pm #12099
    Avatar photoIRMA88
    • Topics: 2
    • Replies: 39
    • Total: 41
    • Recovery Champion
    • ★★★★
    @irma88

    #woohoo! Great news :)

    G2B – DIAGNOSED 2014, STARTED SOF/DAC 11/11/15 VL 6M
    UND @ WEEK4
    FINISHED TREATMENT 26/4/16
    UND @ WEEK 24
    ALT 12 AST 15
    MY ETERNAL GRATITUDE TO GREG JEFFERYS & DR FREEMAN

    18 February 2016 at 9:02 am #12162
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Just heard back from the clinic with my 12 week VL results, big drum roll………..

    Not Detected!!! :woohoo:

    :+1: A big “Thank You!” to Dr James and all of the people behind the scenes at FixHepC who made this possible. :+1:

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    18 February 2016 at 10:46 am #12166
    Avatar photopat1
    • Guardian Angel
    • ★★★★★
    @pat1

    GAJ Congratulations, such a great feeling right!
    I’ve been waiting to hear this news from you.
    #duck #duck #duck #duck #duck #duck

    gt 1a VL 6m
    F2/3 FibroScan – 9KPa in 2011 and 7KPa in 2015
    sof/dac 10 December for 12 weeks
    pre tx alt 85 ast 51
    4 wk alt 34 ast 31 UND <35
    8 wk alt 29 ast 32 UND <15
    12wk alt 25 ast 25 EOT 3.3.16
    SVR24 UND KPa5.3 F0 in normal range
    I am well
    .forever grateful to fixhepc

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