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  • 7 January 2016 at 3:03 am #8203
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    Ahhhh..
    Inchgalbraith…
    The old family stronghold on Loch Lomond.

    https://en.m.wikipedia.org/wiki/Inchgalbraith

    M

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    7 January 2016 at 3:07 am #8205
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Aye, you can’t beat that warming wail of the bagpipes in the distance…

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    7 January 2016 at 3:10 am #8206
    Avatar photoLondonGirl
    • Guardian Angel
    • ★★★★★
    @londongirl

    I think yer’s names spelt LEFFE!! Nae LIFE!

    :lol: Voloro –

    GT1a Dec14 F2/8.7 VL 900000-2.5M
    Jan16 Hepcivir-L MonkMed/Redemption
    Baseline: VL 913575 Alt 76 Platelets low
    Wk2 VL1157 Alt 23
    DET Wk 8 VL 32 Alt19 ‘In the slow lane’
    June16 Fibro 5.7 F0/1 LIF 1.5
    Wk 11 VL<12 Alt 13 Det/Unq
    Extending tx 12 wks Mylan Sofo/Dac MonkMed
    Wk 14 VL <12 Det/Unq
    Wk 16 VL UNDETECTED
    Wk 22 + 4 Wks Sunprevir FixHepC
    Wk 24 UNDETECTED Alt 13
    Wk 12 post tx SVR12 Wk 26 SVR24
    Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

    7 January 2016 at 9:26 am #8237
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    GOOD CRACK Wullie!

    I’m still cacking meself. :lol: <img style=ide:' /> <img style=illy:' /> :lol: <img style=ide:' /> <img style=illy:' />

    And amazed that V’s VL can jump from .2m to 6.9m in 13 days.

    8 January 2016 at 7:57 am #8347
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    You funny bugger Wullie! Great laff :lol:

    And I’m with Joy – incredible viral jump in such a short time. Just goes to show what a perniciously virulent bastard the virus is.

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    16 January 2016 at 10:50 am #9422
    Avatar photoChejai
    • Guardian Angel
    • ★★★★★
    @chejai

    Yes, Thank You Vororo I haven’t had such a good laugh in ages :lol: :lol:
    Like 2b I actually started having no trouble all reading/translating :P

    This has been an interesting visit!
    I’m planning on being abstinent through Tx. I’m used to a few vinos at night though. I’m doing my best…. ;)

    QLD Australia ☀️
    G3a HCV 35 yrs Tx naive
    Started Sof/Dac 13/01/16

    Dec ’15
    AST 70
    ALT 89
    GGT 124
    Fibroscore 8.5
    F1-F2
    13 Feb’16 VL UND #woohoo!
    AST 24
    ALT 26
    GGT 50H

    13 February 2016 at 4:37 pm #11863
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hi folks,

    Oor Wullie here!

    If ye ken remember, last yere ma luvver enzyme livels were up an doon like Wee Eck’s yo-yo, an ma maw wis gettin fed up me praktisin ma cattapult in the front room cus ah wusnae aloud tae sit in the Drumnadrochit wi ma paw onymore on account o the virus. She’d aye be tellin me tae up an dae ma haemwurk or awae an plai in the traffic wi ma frends. But a didna reely hae much enerjy for ony a thayse thungs onymore.

    So in the end, me an Wee Jeemie went on-line an foond a super solushun in Australia. An fae the sake o ma poor old maw’s porcelin, me an the lads had a whip-roon an we decidid tae awa doon the offy evry nite durin ma treetment. Anyway, its now three munths later, an a jus thoot I’d gie a wee up-date on the latest results fae ma wee eksperiment wie the swalley.

    Date AST ALT GGT Lipase V-Load Comment
    10-nov-15 82 133 52 135 1.9M Started FixHepC Sof+Dac
    01-dec-15 47 63 46 74 So far so good…
    10-dec-15 47 58 44 < 15 Crivvens! Its reely workin!
    03-feb-16 30 26 30 105 UND EOT – Sléinte!!

    As ye can see fae the tabel, the Sof+Dac has wurked jus perfeckly. Ah ma luvver enzymes are bak tae normel an even the GGT has come rite doon, despite ah the swalleyin wi me pals. So I can only sae tha the good Dr James was absolutly rite (drinking alcohol will not adversely impact your treatment). An at leest in my case, ma wee eksperiment shows that swalleyin durin the treetment had absolutly no negative effect (an in fact it helped tae keep me sane durin the stress o waitin for the figgers tae come oot). OK, its ony n=1, and so not very “sientifik”, but that’s plenty good enuff for me!

    So if there are ony other doktors reedin this, I’d jus like tae sae that ye shoodnae be botherin yer pashents wi stupit questions aboot alcohol. Ye shood jus get on wie it an treet them ah, jus like the Good Dr James does!

    Anyway, ma maw and paw are absultly delited that am back tae ma usuel tricks, even tho they’ve had tae buy me a nyu pair of dungarees cos I’ve put on neerly half a stane (which is aboot 4Kg in forrin money). An ma girlfren Primrose is also super-happy that I am kyured an have ma enerjy back (wink). But she still beets me at fitba, which is a bit of a dooner. Still, naebody’s perfek!

    So I’d jus like tae say I’m awffy grateful tae Dr James and the rest of the FixHepC team! As well as treetin thoosands o folks aroon the wurld, which is nae meen feet, yev also fixed up one o Scotland’s favorite icons! So if yer ever visitin Scotland, yed be maer then welkome to join ma wee gang!

    Sláinte!!
    (Scottish toast)

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    13 February 2016 at 7:13 pm #11876
    Avatar photore_roll
    • Guardian Angel
    • ★★★★★
    @re_roll

    V….excellent downward trend. You are an inspiration for those that wanted real numbers
    posted. But peeps are different and have different reactions to many different things.
    You might have posted it, but could tell us again what amount of alcohol and frequency
    you are following.

    I started tx three days ago. I cut down on my alcohol to 1-2 drink per night. I have enough
    meds to continue treatment longer if after 4 weeks there is no significant improvement.

    Interesting to note though is that the generic sof/led is very powerful and the effect of
    alcohol and other prescription meds are not felt as readily as before….at least that is
    what I have experienced. I will post my results as time passes.

    Good to hear you are making significant progress and congrats on UND EOT……e.

    contracted Gen 1a in the 70’s, dx in 2007…ast 27 to 35…alt 43 to 96…vl 1.2 mil to 8.6 mil.
    biopsy F-2 (2012)..pre tx results 1/23/16 ast 32, alt 46, vl 3.1 mil
    tx started 2/11/16…. lab results 2/24/16 ast 18, alt 18, vl <15 IU/ml
    28 days later………….lab results 3/9/16 ast 21, alt 21, vl UND
    56 days later………….lab results 4/6/16 ast 20, alt 22, vl UND
    139 days later………..lab results 6/29/16 ast 28, alt 30, vl UND…EOT
    SVR24

    13 February 2016 at 8:18 pm #11877
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    Hi Re-roll,

    You’re right, I didn’t post exact numbers for the booze. On a beer-day, it is typically 3 small beers (3×1.3 = 4 UK units) or 1/2 bottle of wine (4.5 units). On a non-beer day it is 0 or 1 small beer (yes, I know!…;). I have had several party-nights, maybe about one every three weeks recently where we go out or have people in. Always a lot of empty wine bottles afterwards! But always spread over the whole evening, and always with lots of food. These days, I am very aware that after such evenings I am in amazingly good shape the next morning, compared a year ago I would have been wiped out the next day (in fact, a year ago, I only ever had a glass or two at parties because I knew that otherwise I would pay for it afterwards…;).

    Putting it all together, I am probably drinking at least something on 5 or 6 days out of 7, and averaging about 25-28 units per week. I believe most doctors in the UK recommend not to regularly exceed 28 units/week. So I think am within “safe” limits.

    Anyway, at first, I put all my figures in a table just for myself because it helps to show up any trends. And then, why not just put them all on-line? Many of us put the key numbers in our signatures anyway…

    Maybe now we take it for granted that many people will get to <15 or UND at 4 weeks. But what really surprised me was that while 6 months off the booze last year brought down the GGT by about 15 points to 50 (almost touching "normal"), just 3 months of Sof+Dac(+Booze) dropped the GGT by an additional 20 points down to 30.

    In the FAQ (http://fixhepc.com/kunena-2015-11-10/faq.html), it says that "GGT will probably remain elevated if you are drinking during treatment, but that's the booze not the bug."

    In my own little experiment (n=1), it certainly looks like its the bug, not the booze…

    Anyway, here’s to sensible drinking…

    Cheers,

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

    16 February 2016 at 6:58 pm #12011
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Anyway, here’s to sensible drinking…

    Reading this post I noticed I had not paid my daily subscription to the French Paradox.

    With that oversight now successfully corrected, nice glass of Barossa Shiraz (Pepperjack) standing sentinel by my side, I recall that we are not the first to notice the benefits…..

    “Behold the rain which descends from heaven upon our vineyards, there it enters the roots of the vines, to be changed into wine, a constant proof that God loves us, and loves to see us happy.” – Benjamin Franklin

    This is usually paraphrased as “Beer is proof that God loves us”

    One of the things that has always fascinated me about public health is the notion that longevity is king. What about quality of life?

    Now the upmarket version of this is:

    “In the end, it’s not the years in your life that count. It’s the life in your years.” – Abraham Lincoln

    Mum has a more succinct take on it

    “Life is not a trial run” – Mum

    But the one I remember best came from a bus driver who found me online and wanted to continue his testosterone supplementation. Now at the time the party line view was that testosterone kills men early (it’s since been found that the men with the lowest levels of testosterone have the highest rates of cardiovascular death) so I gave him the party line about the risk and he told me:

    “You know the problem with you doctors is that you want to add 5 years to the end of my life. I’ll tell you what I know, those years aren’t the best years. If we were talking adding 5 years to my 30’s you’d have my full and undivided attention. What testosterone does for me is improve my sex life, improve my mood, and improve the quality of my life right now. I’m happy to take the risk.”

    He was not a muscle up gym junkie so I wrote the script, and that was probably at the very beginning of the journey that led me here….

    Then again maybe it was this slogan that was on my favourite tshirt until it wore out

    edge.jpg

    YMMV

    16 February 2016 at 9:48 pm #12018
    Avatar photomgalbrai
    • Guardian Angel
    • ★★★★★
    @mgalbrai

    To hell with Arkansas…
    I’m moving to Tasmania….

    Curehcvnow@gmail.com
    http://forums.delphiforums.com/generichcvtx

    G 1a F-1
    Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
    11/17/15 4 wk lab ALT 17 AST 16 <15
    11/18/15 Started Harvoni
    12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
    1/14/16 Fin. Tx
    7/07/16 UND SVR 24

    16 February 2016 at 9:50 pm #12019
    Avatar photore_roll
    • Guardian Angel
    • ★★★★★
    @re_roll

    Agreed 110% about quality over quantity, Dr F. The “living on the edge ” quote is a good one.
    Life is too short as many of us are experiencing now as we get older. I always thought that I
    would die with HCV, not because of it. HCV was going to be another final “edge” until Greg
    Jefferys and FixHepC appeared in my life. I have seen the final edge 4 or 5 times in my lifetime.

    Luck, fate, destiny, karma, etc has been my partner my whole life. I’ve always had cats(and dogs)
    as pets growing up. Cats only now, but the 9 lives thing…I can relate too.

    My decision to drink sensibly while on treatment is my decision and mine only. I have vetted and
    done my due diligence on the topic. Everyone on or soon to be on treatment must make their own
    decision , notwithstanding the medical profession. 99.9% of them will say “DON’T”. Dr F is one of
    the .1%.

    I am keeping a log/journal on my alcohol intake for the next 12 weeks and the results of my lab
    results like Vororo. They will be posted as time goes on.

    contracted Gen 1a in the 70’s, dx in 2007…ast 27 to 35…alt 43 to 96…vl 1.2 mil to 8.6 mil.
    biopsy F-2 (2012)..pre tx results 1/23/16 ast 32, alt 46, vl 3.1 mil
    tx started 2/11/16…. lab results 2/24/16 ast 18, alt 18, vl <15 IU/ml
    28 days later………….lab results 3/9/16 ast 21, alt 21, vl UND
    56 days later………….lab results 4/6/16 ast 20, alt 22, vl UND
    139 days later………..lab results 6/29/16 ast 28, alt 30, vl UND…EOT
    SVR24

    17 February 2016 at 4:44 am #12048
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    aaaa, hell…i drank wine…i been drinking wine, im drinking some wine right now and ….I like red wine….its damn hard to find good red wine in this country, but Im going to keep trying seems like what they send over here from other places is the dregs, (I don’t blame them, keeping the good stuff close to home is an old tradition)….

    but if anyone could recommend me a nice dry red wine from Australia,(that stuff Dr. Freeman is drinking sounds nice, probably can’t find it here)
    or anywhere else that wouldn’t cost an arm and a leg, I would appreciate that lots.

    oh yea, just got back my tests from 1 week after EOT, and still UND!!! (red wine and all)

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    17 February 2016 at 5:13 am #12058
    Avatar photoCJ
    • Guardian Angel
    • ★★★★★
    @cj

    Dr James, you have a wonderful attitude to life.

    You make so much sense in everything you say or suggest, & so caring on top of it all.

    You’d make a perfect Prime Minister.

    Wouldn’t Australia be a better place if that could be possible.

    But bet you’d hate it! You wouldn’t have enough time to do all your living on the edge stuff!! :)
    But I’d definitely vote for you :P

    Cindi x #love

    J the young dragon slayer is:
    HepC 1a since birth
    Male aged 15
    VL 2000000
    Started Twinvir/ 10-11-15-then Sof/led.
    NO sides so far !
    after one week VL : 37
    after 4 wks VL : UND !
    EOT 2/2/16 UND.!
    4 wks. post tx results….pending….
    7/3/16 VL result : 4 week post tx: SVR !
    12 weeks SVR !
    24 wks SVR yeeaa!!

    22 February 2016 at 4:14 am #12407
    Avatar photoVororo
    • Guardian Angel
    • ★★★★★
    @vororo

    … While we’re on the subject of sensible drinking, you’ve gotta hand it to the aussies :)

    https://www.youtube.com/watch?v=OsjlE-fC-gU

    Diagnosed Jan 2015: GT3, A0+F0/F1. Fatigue + Brain-Fog.
    Started Sof+Dac from fixHepC 10-Nov-2015. NO sides.
    Pre-Tx: AST 82, ALT 133, Viral Load 1 900 000.
    Week4: AST 47, ALT 58. VL < 15 (unquantifiable). Week12 (EOT): AST 30, ALT 26, VL UND Week16 (EOT+4): AST 32, ALT 28, GGT 24, VL UND Week28 (EOT+16): AST 26, ALT 22, GGT 24, VL UND Ever grateful to Dr James. Relapsed somewhere after all that... Bummer! Jan 2018: VL 63 000 (still GT3).

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