Hi Phoenix,

Please get LFTs as well. If your ALT is out of range you are probably right, if it is still normal that would be reassuring.

If we need to retreat you that’s possible and can be prompt.

Best

James

NS5A RAVs are typically quite fit so don’t decline quickly. They are not created by treatment, they are selected. Many people have detectable NS5A RAVs at baseline, but all that means is they have enough to count.

If you get the NS5B RAV S282T you do have a problem but that causes on treatment failure, not relapse.

I see no logical basis to delay retreatment for most people, provided we can do something different from last time as in pick one or more of longer, stronger or different drugs.

Hi Phoenix,

I hope you will attain SVR. But, if you are F0-1 at 57 after 39 years of HCV-infected – it is unlikely that you will die from HCV-related cirrhosis (and its complications) even in case of “viral relapse”. Thus, it needs to compare possible benefits and risks of “retreatment attempts”. Serious medications (for example, like interferon or boceprevir) may give more “harm” than “good”. If there is no urgent need for treatment (for example, severe extrahepatic manifestation of HCV – like cryoglobulinemic vasculitis with damage of kidneys) – it may be better to defer treatment in case of relapse after sof+dac failure.

Deferral of treatment is recommended, pending availability of data for patients with HCV genotype 1, regardless of subtype, in whom previous treatment with any HCV nonstructural protein 5A (NS5A) inhibitors has failed, who do not have cirrhosis, and do not have reasons for urgent retreatment.

(http://www.hcvguidelines.org/full-report/retreatment-persons-whom-prior-therapy-has-failed)

I’m too in the same panic boat after EOT last tuesday. I have to wait for one more week to get EOT PCR results, didn’t do any since started Ledifos tx in January. I’m starting to feel some pain in right abdomen as well as itchy skin all over, just like before tx. Yesterday also got one of those awful headaches that last all day.
I’m trying to convince myself it is just my body getting back to normal, but in any case just like Dr.Freeman said will draw blood tomorrow for LFT’s.

Don’t panic! I too have good and bad days and niggling thoughts about relapse, but was UND at 6 weeks into treatment and just got SVR4 result. Some pre-tx symptoms are still there but probably related to things such as age, fitness level, diet, fibromyalgia. osteoarthritis, candida overgrowth or failure to quit smoking (yet).
Think positive but see your doctor and discuss your concerns.