Harvoni side effects continue after treatment ends...

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29 April 2017 at 4:57 pm #25934
beaches
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- Guardian Angel
@beaches
Not a single day off sick, in fact I felt ridiculously good while taking Harvoni. Focused and full of energy. Just felt damn good.
I am twice as old as you, you should do it easy.

Genotype 1a
Diagnosed in 2004, had HCV for all my adult life. Until 2016!!!!
Harvoni treatment, started 19 March 2016
4 week results Bilirubin 12 down from 14 pre treatment,
Gamma 25 down from 52, ALT 19 down from 63, AST 19 down from 47,
VL <15 down from a lazy 6 million or so

EOT Results
Bilirubin 10, GGT 18, ALT 19, AST 21, VL UND

12 Weeks post EOT
Bilirubin 11, GGT 16, ALT 22, AST 20, VL UND
Cured baby
29 April 2017 at 6:29 pm #25936
Dr James
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@fixhepc
Either choice Sofosbuvir + Ledipasvir (Harvoni) or Sofosbuvir + Daclatasvir (Sovaldi + Daklinza) is good.

I don’t have a strong preference but suspect Sofosbuvir + Daclatasvir has a slight edge in terms of both SVR and less side effects.

Some patients on Harvoni do seem to go a bit flat and low on energy 6-8 weeks into treatment.

Most of the side effects – headache and insomnia – are caused by Sofosbuvir in the ~ 20% of patients that get them. You have to have that.

Both should see you cured, and because side effects are relatively rare, and very individual it’s often other things that help decide. Daclatasvir mixes well with almost all HIV drugs, and Harvoni is not great for patients with reflux/heartburn taking medication.

YMMV
29 April 2017 at 7:46 pm #25938
Bogdan16
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- Novice
@bogdan16
So in this case, what is your suggestion ? Which treatment is more appropriate for me ?
Fibrosis: F1-F2
ALT: 125, 15
Naive
Genotype: 1b
VL: between 1.000.000-1.200.000

Thank you !
30 April 2017 at 12:31 am #25939
Mnem
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@mnem
Hi Bogdan 16, Our stomachs have plenty of acid to aid absorption so long as you do not take other drugs that interfere with that. The human stomach is a naturally low pH environment. If you are concerned about other drugs you are taking that could interfere with absorption then use this Liverpool site to check them:
http://www.hep-druginteractions.org/checker

Our good Dr Freeman has given you good advice “Either choice Sosofbuvir + Ledipasvir (Harvoni) or Sofosbuvir + Daclatasvir (Solvadi + Daclinza) is good.”.

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990’s.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
30 April 2017 at 12:50 am #25940
Mnem
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@mnem
Hi Bogdan 16, It was the old Interferon treatments that made people feel too sick to work. We are lucky the DAA drugs are trouble-free, most of us who are on them can play and work as usual throughout treatment.
Best wishes for deciding which treatment will be best to treat your type1. I too found it hard to decide, but you are lucky because you have received good advice from Gaj and Dr James Freeman.

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990’s.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
30 April 2017 at 1:03 am #25941
Bogdan16
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- Novice
@bogdan16
Hi Mnem,

Yes, I have read about interferon treatments and thank God now we have all this new treatments with less side effects and a higher rate of healing . I think I’m gonna go with Sovaldi though.

Best wishes with your treatment, Mnem.
30 April 2017 at 1:12 am #25942
Mnem
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- Guardian Angel
@mnem
Hi Bogdan 16, If you go with Solvadi then you will need to take it together with Daclinza to make it effective. Sofosbuvir + Daclatasvir (Solvadi + Daclinza). You need the combination to be cured

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990’s.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
30 April 2017 at 1:18 am #25943
Bogdan16
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- Novice
@bogdan16
Yes

REDEMPTION 2 eTrial – generic Sovaldi® (Sofosbuvir 400 mg) and Daklinza® (Daclatasvir 60 gm)
REDEMPTION 3 eTrial – generic Harvoni® (Sofosbuvir 400 mg / Ledipasvir 90 mg)
REDEMPTION 4 eTrial – generic Epclusa® (Sofosbuvir 400 mg / Velpatasvir 100 mg)
4 May 2017 at 10:24 am #25969
coral
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- Guardian Angel
@coral
Hi Bogdan,

Congratulations on pursuing treatment. As others have mentioned the side effects for these medications are generally mild. That’s not to say that people haven’t experienced them to a greater or lesser degree. Generally they seem to involve headaches, fatigue and insomnia (sometimes related ofcourse) but it would be unusual for them to affect your ability to work. The key seems to be to focus a little on your general health, eat well, drink lots of water and try to rest when possible.

Good luck Bogdan.
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