Hi Mike,
Did you not test the Mesochem meds at all before you started tx then? Obviously if you are feeling well, you’re good to go though..I know it can be terribly expensive for testing, but love hearing about everything coming out of China as testing perfectly safe. Thanks!

Hi everyone,

It is safe to assume that Mesochem make batches of several Kg at at time and no doubt they have their own quality control procedures just like any other large industrial manufacturer. So once they know that they are producing pure API, there is no reason to suppose they will suddenly start producing junk.

Since the fixHepC team test every batch they receive, which is probably just a small fraction of each Mesochem batch, it is extremely unlikely that anything bought from Mesochem will be less than top quality.

The only doubt could be if someone buys what they believe to be Mesochem product through an unknown agency.

Still, this is not to say that fixHepC should stop testing. This extra level of confidence is invaluable for anyone sourcing through fixHepC, and also for defusing the Big Pharma myth that there could be a risk associated with “generic” APIs.

If a molecule from Mesochem, or Beacon, or Incepta, or anywhere else, is provably the same molecule as a “brand-name” molecule, then it is the same API as the brand-name API with precisely the same pharmaceutical properties.

Water is water is H20, or whatever else you want to call it.

Same thing for sofosbuvir if you can prove it using mass spectroscopy and NMR.

————————————–
Technical note for chemists:

In fact, it is not absolutely as clear-cut is this if a molecule contains chiral centres (which is the case for sofosbuvir) because it is possible for a molecule with the same chemical formula to have different stereo-isomers, and sometimes only one of the stereo-isomers is biologically active. But even stereo-isomers can normally be differentiated by NMR (one of Jame’s tests: http://fixhepc.com/blog/item/16-testing-provisions-patient-safety.html).

According to a detailed report by the European Medicines agency

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002798/WC500160600.pdf

Sofosbuvir has 6 stereogenic centres, which “are well controlled by the synthetic process and the specifications of the raw materials.” (page 14) “… and the manufacturing process consistently produces Sofosbuvir as the most thermodynamically stable polymorphic form… Other polymorphic forms are excluded by the manufacturing process and their absence is confirmed by DSC.”

(DSC = differential scanning calorimetry).

End of technical note.
—————————————-

So if James has a good reference NMR spectrum (and there is every reason to believe that he does), then the generic APIs sourced on our behalf by fixHepC can safely be assumed to be nothing less than the genuine product…

Good to hear of your progress Sean…may it continue to be sides-free, and UNDETECTED at 4 weeks.

SShady43, I got the Mesochem Sof & Dac and did not have them tested as I am in Japan and it is not possible to do so here. I just had blood tests done after 16 days to verify that the drugs were working and that there were no problems. My results came back quite good. AST down from 74 to 23 – normal, ALT down from 140 to 21 – normal, and viral load down from 5.6 L.IU/mL to 2.2 L.IU/mL. Not quite undetected but getting very close and quite a massive drop, and after only 16 days. All other tests were in the normal ranges, as well. My dealings with Mesochem were efficient and professional on their part. I did not have a prescription and I ordered my Sof/Dac in late July this year. best of luck. Gary

Test Unit Mike, agreed about building faith. I tried to find a company in China or Japan to test the goods but most simply did not reply to the emails or gave a stock reply informing me that they would love my business as long as I would jump through numerous hoops and pays ridiculous amounts of money. As for Mesochem, I think some people still have an image of made in China products being inferior to other countries goods or fake (there are MANY so buyer beware is strongly advised) but China does have world class companies making excellent goods, as well. Even my wife, who is from Shanghai, advised me to tread carefully. In the end I figured as the Fixhepc folks had verified the quality many times over that I should just test it on myself, as you have, and have bloods done after 2 weeks just to confirm everything was as it should be. I am very, very happy I did so and hope your and my results help others who may be sitting on the fence debating what to do. My only advice to people considering doing as we have is to ONLY buy from a company that has supplied verified goods, independent tested – (Mesochem in China and others in various countries now ) buying from any old company on Alibaba is a risk I wouldn’t even consider unless i was at death’s door and had absolutely no other option. Hope your Test continues to go well and you make it to Tasmania as a healthy man, sooner rather than later. Best, Test Unit Gary

Good for you Sean, so happy for you! Good luck!!