Yes, and didn’t notice any difference between compounded (capsules) and formulated (tablets). The anti depressant tablets you are thinking of are slow release. They are designed to gradually release the active ingredients over an extended period of several hours so you get a small steady dose which is what you want with something designed to ‘stabilise’ you. On the other hand HCV DAAs are designed to dissolve and release the full dose almost immediately they enter your stomach so that it is absorbed into your bloodstream rapidly.

Hi Maylily and welcome.

Congratulations on commencing treatment.

As you will have read in this thread most people find Sofosbuvir + Daclatasvir to be fairly easy to take with mild side effects although these seem to vary from person to person so it is difficult to predict which, if any, you will experience. I did notIce the lightheaded/dizzy feeling you mention at the start of my treatment. I found that it reduced considerably over the first week as I adjusted to the meds although the ‘full’ or ‘thick’ effect remained mildly present for a while longer. From my experience these medications do seem to increase our fluids requirements a bit so ensuring you drink plenty of fluids throughout the day to stay well hydrated will assist to reduce any side effects you experience.

Thank you Gaj and Coral for your answers!

As Coral suggested, I searched this forum for these specific side effects that I experienced, but did not find anything. So I figured I should ask here. Now I feel calmer to know that this dizzy feeling side effect is “normal”. I will also try to drink more water. I am not a big water drinker, so it is harder for me to remember to do it

Thanks again for your help!

12 days into Sofosbuvir/ Daclatasvir ( I am G3 responder /relapser from Interferon/Ribavirin) . last 3 days fairly strong flu symptoms; headache , sore throat, very tired . Anyone else been through the same sequence ?

Hi Neil,

I had milder versions of your side effects, although the headaches could be quite bad and I could usually trace them back to not drinking enough water. Disrupted sleep was also a biggie for me. Over time I have seen all of your side effects on this forum and more, so you’re in excellent company and on your way to being cured.

I see you are a relapser from interferon so all kudos to you for getting onto the new treatment and finding this site. The treatment can generate a bit of anxiety especially for those of us who relapsed so I found making my best attempt to eat well, exercise and drink lots of water did help. I am not 7 weeks post treatment and it’s all going well.

Post any questions or thoughts you have. You couldn’t wish for better companions than the people on this site.

Coral

Hi Neil,

I was one of the very small percentage who relapsed on the new DAAs. I started on Sofosbuvir/Ledipasvir then Sofosbuvir/Daclatasvir (due to an initial slow response) so even though it was devastating I didn’t have to go through the horror of interferon like you. I also knew that there were new drugs coming down the pipeline for relapsers. During my second treatment I also took Ribavirin which caused a few more side effects like headaches, skin/hair issues but a small price to pay.

My recent blood test at SVR6 looks great so the next test at 12 weeks will be a good indicator of good news at 24 weeks.
It was around this 8 week post treatment period that I realised I had relapsed last time so just hanging in there with a few things crossed. I have absolute faith that the cure is there for all of us. Some of us just have different pathways.

Hope things are settling down for you. I did find that I became hyper sensitive to how I was feeling and as Dr F said sometimes we do just get normal illnesses during treatment. Hope things have settled down for you. Coral

Had a big sore throat and flu etc which I thought was was side effects so didn’t get treatment for it specifically . Pain moved to my ear and the inflammation burst , perforating my ear drum . Set me back completely , very bad pain . Massive pain killers and antibiotics . Feeling dizzy but with all the combination of drugs in me that’s not surprising . ( I’m also on blood pressure drugs , statins and anti coagulants following a stroke last year )
Along with the tiredness from the DAA I’m pretty much on the floor at the moment . on the point of packing up the DAAs. Going back to GP and HepC Doc this week .
If you have symptoms my advice is get them checked out ,,they may be the real thing , like my infection , which , if not treated as it should be , could be really damaging .