Home Forums Main Forum Patient Stories Relapse Corner – Next Steps Sigh… GT3a Tx Failure

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  • #25511
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello hepCat,

    Really sorry to hear about your relapse.

    The sad reality of <100% statistics is that some people fall into the relapse group.

    Yes, Sof+Vel+Vox (and probably with Ribavirin) is what you should be chasing. Zepatier + Sofosbuvir is similar.

    Happy to have a chat offline, or here.


    YMMV

    #25513
    lukemeister1990
    • Topics: 1
    • Replies: 12
    • Total: 13
    • Acolyte
    • ★★
    @lukemeister1990

    I don’t know how HCV works… In my case after EOT I don’t feel much better. In my opinion I feel even worst during the time I had to swallow sofosbuvir and daclatasvir pills.

    My situation was quite similar to yours. I was undetected since 18th day of treatment. Additionally I got HCV-RNA test in the middle and in the end of treatement, Both were negative. I followed Doc. Freeman advise and I’ve extended my treatment to 24 weeks- F2 (9.2 kPa) and VL: 1,23*10^6 IU/ml. Today I received SVR4 HCV-RNA test: HCV virus is not detected. Now I am wait for SVR12… and whatever tomorrow brings.


    GT 3a
    Contracted: October 2008
    Diagnosed: March 2009
    First treatement:
    VL 250.000 IU/ml
    Fibrosis F0
    Start: November 2010
    Copegus+Pegasys (24 weeks)
    EOT: VL UND
    SVR24: VL DETECTED
    June 2016
    Fibrosis F2 (9.1 kPa)
    VL 1.230.000 IU/ml
    Second treatement:
    SoviHep+DaciHep (24 weeks)
    Start: 13.08.2016
    VL UND: 30.08.2016
    VL UND: 27.01.2017 (EOT)
    EOT+4 weeks: AlAT 9.8 SVR4
    EOT+8 weeks: AlAT 9.7
    EOT+12 weeks: AlAT 7.0
    EOT+28 weeks: AlAT 7.6 SVR28

    #25514
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Lukemeister,

    Congrats on the SVR4. The drugs should be mostly washed out of your body now. If you felt unwell taking them it’s fair to say they only just agreed with you so we would expect things to improve.

    It would be worth trailing some vitamin B12 to see if that helps and checking both thyroid and for diabetes.


    YMMV

    #25541
    Avatar photocoral
    • Guardian Angel
    • ★★★★★
    @coral

    Hi hepCat,

    I’m really sorry to hear about your relapse. There are a few of us here that know exactly how you feel. Like you I was disappointed and also quite sad as I had so looked forward to experiencing a HepC free life after so many years of dragging the baggage around with me. I also did the guilt thing about “what did I do to stuff it up”. which is understandable but not useful.

    I can see though that you’re working your way through it and despite the frustration of “why” you’re looking forward. I’ve now completed another treatment and am sitting in the waiting room again. My second round included one of the big guns Ribavirin and the virus fled very early in my treatment which was a good sign. I don’t doubt that this will be the same for you.

    Good luck with your next steps. #flower #flower

    Coral #flower #flower

    #25550
    Avatar photoFara
    • Topics: 1
    • Replies: 82
    • Total: 83
    • Guardian Angel
    • ★★★★★
    @fara

    Hi HepCat, …I am also very sorry to hear of your relapse. .There are more options now with other new drugs, you will be

    able to beat this on the next round. ..Good news though that you are feeling well.; . sounds like you were doing everything

    right. Best of luck with the next treatment…. #flower


    HCV since 35-40yrs., GT 1a , Dx 2004; VL 4-5 mil, F2-3
    Tx sof/led started 3/4/16
    4wks VL <15
    9 weeks VL UND, ; Alt-15,Ast-13
    16 weeks VL UND Alt-20, Ast-22;
    EOT 24 wks UND
    SVR 4 UND
    SVR 12 UND, Alt.15, Ast. 17
    SVR 24 UND

    #25571
    Avatar photodoxner
    • Topics: 0
    • Replies: 36
    • Total: 36
    • Treatment Warrior
    • ★★★
    @doxner

    so sorry bro to read about your situation. hope some new med-combinations can bring help for you and you stay tight untill then!


    Genotype 1a, since 1990
    Results 2009: ISHAK 2, METAVIR Score 1, Fibrose Stiffness 6.4 kPa
    Results 20/12/2016: HCV RNA (2016) >10 Mio. / AST 60 / ALT 88 / GGT 248
    Starting Therapy: 29/12/2016 with Panovir (Incepta, for 84 days)
    Results 18/01/2017: CV RNA quant. PCR * < 10 / AST 23 / ALT 31 / GGT not tested Results 02/02/2017: AST 25, ALT 38, GGT 54, HCV RNA UNDETECTED

    #25573
    Avatar photosabrecat
    • Guardian Angel
    • ★★★★★
    @sabrecat

    Hi HepCat,

    I have just finished 6 months re-treatment and understand that the virus does not want to leave us cats alone.

    Second time around I found that AFP was down to 2, rather then 4, and LFT’s were all normal without the slight elevation the first time around.

    Red cells and platelets were a sad storey ……..

    Keep up the fight as I think the virus takes some convincing it s not welcome anymore.

    yours

    Jeff

    #29837
    Dave Droid
    • Topics: 0
    • Replies: 1
    • Total: 1
    • Novice
    @dave-droid

    Damn. I’ve had 3 months dac/sof gen 3a, no cirrhosis (metavir F2) and at week 8 I was still detectable (40). I was certain I failed, but at EOT I was undetected and thank goodness I stayed undetected.

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