Sofosvel (velpatasvir)

This topic has 92 replies, 25 voices, and was last updated 8 years, 1 month ago by vitrus.

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20 August 2016 at 2:23 am #22360
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
Good luck with it this time round mate.

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
20 August 2016 at 2:42 am #22361
Ariel
- Topics: 3
- Replies: 1,060
- Total: 1,063
- Guardian Angel
@ariel
Too right everything that’s been said and my support too add it in too Splitdog I am backing you go for it until those buggers have Buggered off
I’m certain you are charged gladiator style and full on for the conquering ahead
Go Splidog
Love and support from Ariel
20 August 2016 at 3:12 am #22366
Greedfighter
- Topics: 28
- Replies: 582
- Total: 610
- Guardian Angel
@greedfighter
This is it Splitdog, you’re gonna win
25 August 2016 at 1:27 am #22487
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
Sofosvel came today from Beacon. Dr. Freeman recommended I wait until Voxilaprevir becomes available for the triple-cocktail treatment. It will be hard, but I will wait. I recently had a fibroScan test done and I just entered into F3. The shipment from Beacon went smooth as silk. I got a script from Dr. Freeman, which he forwarded to Beacon, then the bank transfer. That was all that was required. It came to the US in 3 days.
Attachments:
splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
25 August 2016 at 2:12 am #22490
Ariel
- Topics: 3
- Replies: 1,060
- Total: 1,063
- Guardian Angel
@ariel
Good luck Splitdog although luck isn’t even enough I want to say more than just luck it sounds glib and I’m trying to tell you how great this is and thank you for posting the picture and affirming the process.
I love the chillis and glass cleaner and a texas something bottle in the pic what combo was that hahaha (jokes)
This step forward must have helped you feel more confident great to read real stuff real treatment stories and the more testing times should be shared I believe
Backing you Splitdog for cure. Thanks again for the post it will surely give others hope
Sending love
Ariel
25 August 2016 at 2:27 am #22494
Paul-Jarman-facebook
- Topics: 8
- Replies: 373
- Total: 381
- Guardian Angel
@paul-jarman-facebook
So Voxilaprevir is the mysterious GS-9857 which is a Ns3 protease inhibitor like simeprevir I think when is it due out ? I hope it works out for you this time Splitdog.

Cheers

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
25 August 2016 at 3:20 am #22499
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
Yes, GS-9857. I don’t want to hex anything, but the triple combo I believe gave 99% with type 3 previous DAA failures. The first results from phase III trials will be available in January.
Thank you, Paul.

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
25 August 2016 at 3:25 am #22500
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
Thank you, Ariel. I grow and eat exotic chiles. If I’m not sweating, it ain’t hot enough!

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
25 August 2016 at 4:18 am #22501
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Go get ’em, Split!
99%.
I like it!
m

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
25 August 2016 at 7:01 am #22505
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
Should we start a new thread titled ‘Vox”?

I found this today:
In summary, administration of multiple doses of GS-9857 was well tolerated and resulted in a robust decline of HCV RNA levels in patients with genotype 1–4 HCV infection. Notably, the potent antiviral activity of GS-9857 was preserved in the presence of commonly observed NS3 mutations associated with resistance to protease inhibitors. GS-9857 demonstrated linear PK when administered at doses ranging from 50 to 300 mg under fasting conditions. The median half-life of GS-9857 ranged from 29 to 42 h, conducive to once-daily dosing. Lastly, GS-9857 has demonstrated additive antiviral activity when evaluated in vitro in combination with sofosbuvir or velpatasvir.[5] Together, these data support the further development of once-daily GS-9857 in combination with other DAAs for the treatment of patients with chronic HCV infection.
Attachments:
- 1-3-2.pdf
splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
25 August 2016 at 1:50 pm #22516
pat1
- Topics: 5
- Replies: 334
- Total: 339
- Guardian Angel
@pat1
Awesome pic Splitdog. Best wishes from me for treatment with these new meds. It was was interesting to read the data that you have put up as well. Beacon came through and so all in all very encouraging news. you have the very best support team in the world with you

gt 1a VL 6m
F2/3 FibroScan – 9KPa in 2011 and 7KPa in 2015
sof/dac 10 December for 12 weeks
pre tx alt 85 ast 51
4 wk alt 34 ast 31 UND <35
8 wk alt 29 ast 32 UND <15
12wk alt 25 ast 25 EOT 3.3.16
SVR24 UND KPa5.3 F0 in normal range
I am well
.forever grateful to fixhepc
25 August 2016 at 9:58 pm #22521
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
Thank you Pat and Mike. I can’t wait to wage war on these bastards!!!

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
26 August 2016 at 1:40 am #22527
Ariel
- Topics: 3
- Replies: 1,060
- Total: 1,063
- Guardian Angel
@ariel
Ha! Split you can eat those chillies for me! Between Mike with his garlic cloves in Transylvania and you with your chilies you have my food intolerances I have deeveloped post old tx sorted. These two things I now simply cannot eat! No more chilli no more garlic! Once was a lover of both, now my tummy says NO!
I loved you photo.
Have a great spicy flavoured day Splitdog, Happies from Ariel
27 August 2016 at 8:51 am #22566
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
splitdog wrote:

Should we start a new thread titled ‘Vox”?

Done, click on link below.

https://fixhepc.com/forum/relapse-corner/1263-voxilaprevir-a-new-protease-inhibitor.html

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
28 August 2016 at 1:01 am #22573
vitrus
- Topics: 1
- Replies: 35
- Total: 36
- Treatment Warrior
@vitrus
Vox works best for retreatment. It has gastrointestinal side effects, however it is effective for previous sof failures.
Vel is not very effective for previous sof relapsers, but is recommended for treatment-naive people, because it has no vox-related side effects.

Gen 1b
VL pre treatment 29000 ME/ml
AST 32 ALT 94, F0
Started treatment 13 January 2017
Generic sofosbuvir/velpatasvir (Incepta)
VL 9 days into treatment <300 (undetected)
AST 13.8 ALT 22
Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about
Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60.
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