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  • 13 June 2016 at 12:14 pm #18988
    Avatar photoMichael-Henry-facebook
    • Topics: 9
    • Replies: 39
    • Total: 48
    • Recovery Champion
    • ★★★★
    @michael-henry-facebook

    Has anyone experienced their WCC increasing after completing DAA treatment ?
    Start of treatment WCC 8.4, neut 3.18, lymph 4.26
    EOT 6 weeks WCC 16.3, neut 7.68, lymph 7.53
    ?????

    AUSTRALIAN
    HCV Genotype 1a
    2003 Relapsed Peg Interferon / Ribavirin
    Pre treatment VL 2,000,000
    ALT 65, AST 42, ALP 111, GGT 56
    Bridging F3-4
    Treatment -24 weeks – Sof , Led with 12 weeks Riba.
    4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
    12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
    24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
    EOT 6th April 2016
    SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20

    13 June 2016 at 3:31 pm #18991
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Michael,

    As discussed this is something that needs hematology review.

    YMMV

    19 June 2016 at 2:15 am #19464
    Avatar photoMichael-Henry-facebook
    • Topics: 9
    • Replies: 39
    • Total: 48
    • Recovery Champion
    • ★★★★
    @michael-henry-facebook

    Thanks Dr James,
    Will update after seeing Haemotologist tomorrow.

    AUSTRALIAN
    HCV Genotype 1a
    2003 Relapsed Peg Interferon / Ribavirin
    Pre treatment VL 2,000,000
    ALT 65, AST 42, ALP 111, GGT 56
    Bridging F3-4
    Treatment -24 weeks – Sof , Led with 12 weeks Riba.
    4 weeks VL <12 Detected ALP 89 , GGT 21 , ALT 17 , AST14
    12 weeks VL Undetected ALP 96, GGT 22, ALT 20, AST 20
    24 weeks VL Undetected ALP 83, GGT 20, ALT 21, AST 14
    EOT 6th April 2016
    SVR 5 weeks VL Undetected ALP 81, GGT 31, ALT 22, AST 20

    26 June 2016 at 1:26 pm #19954
    Michael Henry
    • Topics: 1
    • Replies: 19
    • Total: 20
    • Treatment Warrior
    • ★★★
    @michael-henry

    Had all my blood tests done & seen my haematologist the other day.
    He told me that I have very early stage Chronic Lymphoma Lukemia.
    This can be brought on by HCV or just being a male over 60.
    Let’s hope my SVR 12 comes in undetected next week. :)

    Australian
    Geno type 1a
    Fibrosis 3-4
    Treatment experienced Peg-Interferon Ribavirin (Relapsed)
    Started 22/10/15 DAA’s 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
    Viral Load at week 4 <15 Detected
    Viral Load at week 12 Undetected
    Viral Load at week 24 Undetected
    Viral Load SVR4 Undetected
    Viral Load SVR12 Undetected

    28 June 2016 at 2:49 am #20017
    Avatar photoHazel
    • Guardian Angel
    • ★★★★★
    @hazel

    Tough news Michael, not fair to have slayed one dragon and have another appear. From hobbit land I hope you do a Baggins on it and out manoeuvre. Best of luck for your SVR coming up too.

    Genotype 3 30 years, 2x treatment interferon/ribavirin non responder. Cirrhosis 17 years. Fibroscan, decompensating, 40 down to 22 by 29/3/16- now down to 6.5, normal, no cirrhosis. Started Buyers Club Sof/Dac 14 Nov 15. SVR 12 29/0716

    28 June 2016 at 3:09 am #20018
    Avatar photofitz
    • Guardian Angel
    • ★★★★★
    @fitz

    One dragon at a time, Michael. Hopefully its one down and one to go. Wishing good things for you.

    Fitz

    28 June 2016 at 4:32 am #20026
    Michael Henry
    • Topics: 1
    • Replies: 19
    • Total: 20
    • Treatment Warrior
    • ★★★
    @michael-henry

    Thanks guys for the thoughts & encouragement .
    Yes, one dragon at a time lol.
    It was interesting to see the link between HCV & Chronic Lymphocytic Leukemia (CLL)
    The good thing is, that not everyone that has HCV will contract CLL . (Only me :) )
    One thing I found out from my haematologist, was that CLL is very hard to treat if you have the hepC virus.
    So it’s starting to be very important for me to clear this virus before I need treatment for the CLL .
    There’s only about 1% that reach the point in needing treatment in the first year. The rest could be somewhere up until 10 years later. ( let’s hope that’s where I am)
    Having my SVR 12 blood test done tomorrow. Boy!!!!! Is that 12 day wait for the results going to feel like a lifetime.

    Australian
    Geno type 1a
    Fibrosis 3-4
    Treatment experienced Peg-Interferon Ribavirin (Relapsed)
    Started 22/10/15 DAA’s 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
    Viral Load at week 4 <15 Detected
    Viral Load at week 12 Undetected
    Viral Load at week 24 Undetected
    Viral Load SVR4 Undetected
    Viral Load SVR12 Undetected

    28 June 2016 at 4:43 am #20028
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    Hi Michael, I’m sorry to hear of this development. I hope your SVR 12 comes back positive. Then onward to defeating this problem too. :cheer: :+1:

    28 June 2016 at 5:04 am #20032
    Michael Henry
    • Topics: 1
    • Replies: 19
    • Total: 20
    • Treatment Warrior
    • ★★★
    @michael-henry
    Greedfighter wrote:

    Hi Michael, I’m sorry to hear of this development. I hope your SVR 12 comes back positive. Then onward to defeating this problem too. :cheer: :+1:

    Thanks GF, I know what you mean, but I would like my result to be negative :) :)

    Australian
    Geno type 1a
    Fibrosis 3-4
    Treatment experienced Peg-Interferon Ribavirin (Relapsed)
    Started 22/10/15 DAA’s 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
    Viral Load at week 4 <15 Detected
    Viral Load at week 12 Undetected
    Viral Load at week 24 Undetected
    Viral Load SVR4 Undetected
    Viral Load SVR12 Undetected

    28 June 2016 at 5:10 am #20033
    Avatar photoGreedfighter
    • Guardian Angel
    • ★★★★★
    @greedfighter

    Yes negative for VL, so a positive Sustained Viral Response! :cheer: :+1:

    28 June 2016 at 8:26 am #20042
    Michael Henry
    • Topics: 1
    • Replies: 19
    • Total: 20
    • Treatment Warrior
    • ★★★
    @michael-henry

    yes of course GF.
    Sorry I got that arse about :)
    I’ve just been looking for “negitive” PCR RNA VL results for the 24 weeks of treatment.
    Never thought of looking at SVR as a positive result.
    Positive attitude , Positive outlook, Positive result.
    :) :) :) :) :)

    Australian
    Geno type 1a
    Fibrosis 3-4
    Treatment experienced Peg-Interferon Ribavirin (Relapsed)
    Started 22/10/15 DAA’s 24 weeks Sofosbuvir Ledisbovir & 12 weeks Ribavirin
    Viral Load at week 4 <15 Detected
    Viral Load at week 12 Undetected
    Viral Load at week 24 Undetected
    Viral Load SVR4 Undetected
    Viral Load SVR12 Undetected

    28 June 2016 at 9:24 am #20046
    Avatar photoGT2
    • Guardian Angel
    • ★★★★★
    @gt2

    Hi Michael

    Love your attitude to your latest diagnosis of CLL … it’s just another hurdle you’ll jump over.

    Good luck tomorrow. Keep busy, and hopefully the next 12 days will fly by and we will all be celebrating with you on your SVR 12 result.

    I’ve got my fingers crossed for you.

    PositiveAttitude.jpg

    Cheers

    GT2

    1983: Hospitalised with Acute non-A, non-B Hepatitis after ICU blood transfusion 3mths earlier => HCV GT2
    22/02/16: (pre-tmt) ALT 61, VL 2.48 IU/ml Hepascore 0.32 (F1/2), fatigue, brain fog, bloating (Treatment Naïve)
    10/04/16: (Start tmt) Sofovir +DaclaHep (SOF + DCV) by Hetero Labs in India
    09/05/16: ALT 34, VL: NOT Detected :cheer: 🙂 , FBG 11.9 :huh:
    17/6/16 FBG 5.7; PPBG (@14.22) 6.9 (@ 20.45) 7.1; BP 124/72
    🙂 (Accu-Chek Mobile & Omron Auto BP Monitor) 🙂

    28 June 2016 at 5:01 pm #20058
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    And if you do end up needing treatment Rituximab is about to arrive as a bio similar so you could avoid the harsh routine chemo and do generics #2

    YMMV

    28 June 2016 at 7:03 pm #20059
    Avatar photoMatt-Kenney-google
    • Guardian Angel
    • ★★★★★
    @matt-kenney-google

    Well Micheal, just getting a new day started here in the US and now eagerly awaiting your test results… I’m sure not as eagerly as you, but none the less, we’re like family here. What affects one affects all :) so, good, positively negative results on svr12 today my brother … and cheering you on to victory in the battle ahead. :+1:

    GT1a; Got it some time in the 70’s; Diagnosed @1976
    Tx naive
    METAVIR: A2-F2
    SOT May 18, 2016: CMP: AST 162 ALT 241 VL 13000000
    3 weeks after SOT: AST 27 ALT 31 VL 138
    Reached EOT Aug. 10, 2016 / Received svr4 results Sept. 20, 2016: AST 22 ALT 24
    Hep C RNA NOT DETECTED”

    28 June 2016 at 10:11 pm #20067
    Avatar photoTina-Hill-facebook
    • Guardian Angel
    • ★★★★★
    @tina-hill-facebook

    Hi Michael Im sorry to hear of this news – talk about a bump in the road. Ive got my fingers and toes crossed for a SVR 12 to grace your path report.

    T

    SVR 24

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