Forum Replies Created

Viewing 15 posts - 1,801 through 1,815 (of 1,968 total)
  • Author
    Posts
  • in reply to: Glossary? #3739
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Check out the new tab on the Forum.

    Please add suggestions to this thread.


    YMMV

    in reply to: MNR Medication Testing #3723
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello Angus,

    No we don’t currently supply them as individual sheets due to the extra work involved.

    I don’t think reassurance is the major issue – pretty much every liver clinic and gastroenterologist in Australia will now have personally seen RVR from generic DAA medications, but still decline to script it.

    Medicine is conservative and data does not change that.

    For your peace of mind here’s what it looks like in raw form:


    YMMV

    in reply to: Sofosburvir + Daclatasvir (Changed from led day4) #3680
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes, you could make a good case for just take a course of Nexium HP7 while waiting for meds to arrive. 7 days of Nexium + Antibiotics.


    YMMV

    in reply to: Sofosburvir + Daclatasvir (Changed from led day4) #3663
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    You need stomach acidity to help Ledipasvir absorbtion.

    I recommend Daclatasvir for anyone on a PPI who can not stop it because of this issue. Some people exercise their free will and subscribe to the Harvoni is better marketing.

    • If your heartburn is worse at night, put some bricks under the head of your bed to allow gravity to help keep the acid in your stomach.
    • If your heartburn is made worse by certain foods don’t eat them, take less PPI during treatment.
    • If you must take a PPI take the smallest dose possible.
    • If you must take a PPI take it 2 hours after the Ledipasvir so you are loading the Led during the most acidic time and there is time for it to be absorbed.
    • If you are small in bodyweight you are getting more of a dose in mg/kg terms than if you are large where a small reduction may be significant.

    I do know of some doctors giving Sof+Led+Dac. It is experimental although the results of a 50 patient series I have seen are very impressive. It is not recommended in any guidelines but might be an idea to add Daclatasvir if you were say largish and could not stop the PPI.


    YMMV

    in reply to: Liver Clinics and Generic Rebels #3660
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I request a Hep C Viral Load which is reported as (say) reading a pre-treatment result

    HCVL RNA – HCV RNA Detected
    HCV Viral Load – 1,000,000
    HCV Log Viral Load – 6

    So essentially all 3 are reported.

    There is the Detected/Undetected. If it is undetected then they don’t report the viral load.

    If it is detected the the viral load is either a number > 15 or a < 15 (which is the quantification limit). If if is < 15 they don't report the log The Log Viral Load is what the viral load is in terms of 10^x so:

    Viral Load Log Viral Load
    100 2
    1000 3
    10,000 4
    100,000 5
    1,000,000 6
    10,000,000 7
    100,000,000 8

    Essentially the viral load is “count the 0s!”

    You can use the form as is and the lab will know what is required.


    YMMV

    in reply to: Liver Clinics and Generic Rebels #3653
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello I have been to my GP this morning and he said he wasn’t sure which test to run at 4 weeks…..he is fully supportive but I guess just not clear on what tests to run. He has written out the following for me to check which one it is:
    HCVL RNA
    RES HCVL
    LOG HCVL

    Would someone be able to tell me which one it is so I can advise the Doctor when I go to him in 4 weeks. He has other Hep C patients but I suspect has not dealt with the follow up tests simply because the meds are not available here.

    Thanks in advance.

    Lynne


    YMMV

    in reply to: Mesochem #3629
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    I just emailed Mesochem (sales@mesochem.com) to find out prices, ordering, paying and shipping details, whether ID is needed, & crucially whether a script is needed.
    It would be hugely helpful if someone who has already been through the process of ordering from Mesochem could outline their detailed experience of buying meds from them – it feels like a leap in the dark.
    – Anybody in UK know of a Doctor who would give me a script? My GP & Consultant ran a mile when I asked them.
    – Capsulation of the APIs? any tips about that? I gather you can get all you need on Ebay…
    Good luck to all those doing treatment!
    Muir

    My HepC Profile:

    Born 1954, male
    Genotype: 3a
    Infected: early 80s
    Diagnosed: 2013
    Treatment: 24 weeks Int/Riba 2014 relapsed,
    currently waiting for Sof/Int/Riba treatment (12 weeks) on NHS
    Fibroscan: 10.3-F3 in Feb 2014


    YMMV

    in reply to: Buyers Club Scheduled To Meet Key Decision Makers #3619
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    It was a long day’s travel. Neither the minister or her Chief of Staff attended. The people we met were nice but new to their jobs. The PBS guy had a total of 4 days under his belt.

    In short hurry up and wait. We did get confirmation that this year is out and it won’t be any sooner than 6 months. The PBS guy wanted all 5 listed. I suggested how about just one or two and play the players off against each other for price with a “we only need one solution, give us your best price and maybe we will give you our money” – this is what the Kiwis do and they have 8 x better medication pricing than we do.


    YMMV

    in reply to: Liver Clinics and Generic Rebels #3595
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hi Joan How wonderful that you are almost side effect free…..I sure hope I am too. Nonetheless, even if I do get some side effects hopefully they won’t be too bad. Like you, I pretty much react to everything too :) I seem to be not so nervous at the moment, the closer my start date gets the less anxious I am…..will post again over the weekend.


    YMMV

    in reply to: Incepta’s Twinvir #3577
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello ADAM14,

    You need 24 weeks Sof/Led or 24 weeks Sof/Dac +/- Riba

    See page 8/21 http://www.hepatitisc.uw.edu/pdf/treatment-infection/treatment-genotype-1/core-concept/all


    YMMV

    in reply to: Help. Am I taking the right meds? #3575
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    You are on a good treatment. See: http://www.hepatitisc.uw.edu/pdf/treatment-infection/treatment-genotype-1/core-concept/all and page 8/21 Personally I would be on 24 weeks Sof/Led for the reduced sides but 24 weeks Sof/Dac is equivalent and the Riba is a mild booster – don’t panic if you have to drop/reduce to dose of Riba.

    Here are the stats about VL=0 versus time on treatment:

    http://fixhepc.com/forum/experts-corner/287-viral-load-on-treatment-what-to-expect.html


    YMMV

    in reply to: My twinvir story #3574
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc
    in reply to: Hive Swarm! #3567
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Great concept. There are many more patients with HCV than moderators of forums. Our forum is clean due to the hard work of some great mods but you are completely right. There are so many patients with HCV than narrow minded, Pharma funded, mods.

    I love your work!

    PS: I’ve made you a mod here. Now for the Spiderman quote:

    “With great power comes great responsibility”


    YMMV

    in reply to: Study suggests unprecedented 3-week HCV Cure #3565
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Yes start at the beginning with:

    ION-3

    ION-3 was a randomized, open-label trial in treatment-naïve non-cirrhotic subjects with genotype 1 CHC. Subjects were randomized in a 1:1:1 ratio to one of the following three treatment groups and stratified by HCV genotype (1a vs 1b): Harvoni for 8 weeks, Harvoni for 12 weeks, or Harvoni + ribavirin for 8 weeks. The SVR rate was 94% and 96% for the Harvoni 8 and 12-week duration arms, respectively. Ribavirin was not shown to increase the response rates observed with Harvoni. By genotype the SVR rates were: Genotype 1a 93% (8 wks) and 96% (12 wks) and Genotype 1b 98% for both 8 and 12 weeks.

    And then check:

    http://www.uptodate.com/contents/treatment-regimens-for-chronic-hepatitis-c-virus-genotype-1


    YMMV

    in reply to: Liver Clinics and Generic Rebels #3535
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    Hello everyone

    I will start my treatment this Friday (have arranged a week off work next week to see how it all goes)! I have noticed that mostly people on the Forum speak of taking Sof/Dac. I will be taking Sof/Ledipasvir. Is it because of the genotype you are and if there is liver damage etc. that the other combination is prescribed for me? I’m sure it is right, because of course Dr Freeman prescribed it for me however I was just wondering if anyone knew what the different meds were. My liver function, and fibroscan were both good news and I am genotype 1b with viral load of 3.13 million. These tests were done back in February and April respectively.

    Trepidation and excitement are setting in today….I have taken Joan’s advice and am just rolling with the feelings at the moment.

    Lynne


    YMMV

Viewing 15 posts - 1,801 through 1,815 (of 1,968 total)