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  • 27 February 2016 at 8:17 am #12794
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I’m no Dr, but I wouldn’t think it has harmed your chances. Especially since your intake of tea and your dose is staggered.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    27 February 2016 at 8:27 am #12795
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Appreciate your speedy/helpful response Spit Dog…just me being jittery I guess..I received meds approx 3 weeks ago..it’s taken me this long to bite the bullet and commence treatment :)

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 8:41 am #12796
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Hi and welcome,

    Also not a Dr but with the one cup you will be fine, liquorice has been identified as a cyp3a4 inhibitor but I couldn’t find anything on how strong the effect was. As splitdog says and given you are only two days into treatment that won’t be a problem, just don’t keep drinking it. If you search the site for “CYP3a4” you should find plenty on what items to avoid.

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    27 February 2016 at 8:46 am #12797
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    Jack, I’m on the same (Sof/Dac) and am on week 6. I have virtually no side effects. Are you experiencing any?

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

    27 February 2016 at 8:57 am #12798
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Just getting a response from you guys makes me feel less anxious..thanks for responding to me

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 9:00 am #12799
    Avatar photoHit The Road Jack
    • Topics: 4
    • Replies: 24
    • Total: 28
    • Treatment Warrior
    • ★★★
    @hit-the-road-jack

    Hi Spitdog

    Only 2 days in..no sides so far..(touch wood)

    Tx naive. GT3a
    Female
    Diagnosed 1996

    Start 25/2/16
    VL 62700
    F0
    hb 141
    ALT 36
    ALP 81

    4 week test
    VL UND
    ALT 18
    ALP 70

    Additional 4 weeks Tx
    Start 19.5.16

    27 February 2016 at 10:45 am #12805
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    nah, can’t see one cup throwing off 12 weeks of killer meds, but like everyone else said,
    Stop doing that thing!

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    10 March 2016 at 6:48 pm #13630
    dope-on-a-rope.jpgDr James
    • Guardian Angel
    • ★★★★★
    @fixhepc

    This will have no impact.

    CYP3A4 inhibitors increase the levels of Dac so it is likely to:

    1. Be equally or more effective, but
    2. Give more side effects

    YMMV

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