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Dan's Twinvir story 7 years 2 days ago #9426

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Thanks Jolie. Do you know if all other late responders do 12 or 24 weeks?

Yes, I need to pick myself up and hope for good result next week.
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND

Dan's Twinvir story 7 years 2 days ago #9428

Sorry to hear you are down Dan, Try to stay positive, you will get there ,
Susie
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

Dan's Twinvir story 7 years 2 days ago #9430

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Thank you Susie.
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND

Dan's Twinvir story 7 years 2 days ago #9432

#flower #flower #flower
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

Dan's Twinvir story 7 years 2 days ago #9446

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Hi Dan,

Please don't worry, your continually improving ALT says that the treatment is working. As I said before, the scratching from excema won't be re infecting you as long as you are practicing good hygiene.
Your 4 week results showed <LLoQ 12 and the 7 week results will have been the same. That is less than 12 but they just can't accurately measure that low, it could be 1 or even 0.1.
But remember what Enkel has posted previously, also Dr James and even Gilead's trials show some people do not reach UND during treatment but most who are <12 at EOT go on to be UND at SVR12.

fixhepc.com/forum/viral-load-and-svr/570...be-uninfectious.html

I'm sure you will be fine so relax and don't stress yourself over having results that are still very good and continuing to head in the right direction. :) :) :)
G3a since '78 - Dx '12 - F4 (2xHCC)
24wk Tx - PEG/Riba/Dac 2013 relapsed
24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 - 22/06/17 UND
SRV12 - 27/07/17 UND
SVR24 - 26/10/17 UND
:cheer: :cheer: :cheer:

Dan's Twinvir story 7 years 2 days ago #9447

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Thanks Gaj.
I just want make sure that I'm on the right path. Not a lot of stories have tx problems, hence my additional worry. :-(
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND

Dan's Twinvir story 7 years 1 day ago #9456

Dan, I would not worry. Everyone progresses differently. Enkel was undetected at 2 weeks on Twinvir, and his story actually encouraged me to want Twinvir. Undetected at 2 weeks is the best result I have read on this forum! CJ was VL 37 after one week, down from 2 million!

Twinvir was tested, it is a Harvoni copy just like the others. Incepta is a big, quality company. I am sure there is nothing wrong with Twinvir. I feel like it is working. Have faith brother!
Gt 1a, F0, VL 6.5 million, AST 59, ALT 62
Started Twinvir 1/15/16
6 wk. labs VL UND, AST 27, ALT 20
EOT labs VL UND, AST 23, ALT 19
SVR 16, VL UND, AST 28, ALT 17
SVR 24 , VL UND, 10/8/16
SVR 125, VL UND, 9/22/18
SVR 230, VL UND, 10/3/20
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Dan's Twinvir story 7 years 1 day ago #9467

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Dan if you recall at week 6 my VL came back at 17 like you I felt quite deflated as like
you I was reading everyone's stories of UD at week 2.

If you recall, I also posted information pertaining to Gilead and VL which says quite clearly
if you reach EOT and are still detected you've not failed.

In my case, I did my next VL at week 10 it came back UD, I became UD between week
6 and 10 it could have being week 8!

Em, the Mod here also only became UD at I think about week 7/8 so you're not alone.

Dan, I looked at your stats, I know of no G1B whom have failed this treatment we are the easiest
group to treat.

Due to my late blood word, the advise I received prior ( If it came back detected) was to continue treatment
I went through redemption and bought 12 weeks of Harvoni from Cipla.

Though, I am UD I am doing an extra four weeks if i did not have the Med's on hand Id have
finished in Jan 21 there is no way I am doing an extra 12 it makes no sense.

PS. If it comes to extra treatment if you want I can arrange something with the extra 8 weeks I have and don't need.
Sob/Dac from Oct 29 2015
Geno 1b
Fiberscan 9.9 Pre treatment
Fiberscan 7.4 week 10
VL 1.3 million pre treatment
Week 2.5 VL 96
Week 5.5 VL 17
Week 10 VL UD
SVR 3 UD
SVR 16 UD
Cured:
All liver functions in normal ranges.
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Dan's Twinvir story 7 years 1 day ago #9493

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Hi.This is what I was planning, to add at least 4 weeks to the treatment.

Sir - I sent you a private message.

You are all correct, that looking at the others VL brings me down. I need to keep going and hope for the best.

At the same time plan for treatment extention, due to the late response, to make sure I'm clear. It is difficult to take and stop the treatment at 12 weeks and not achieving UND.

On NHS my treatment would have stopped today at 8 weeks :-).
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND

Dan's Twinvir story 7 years 1 day ago #9500

On NHS my treatment would have stopped today at 8 weeks :-).


Good point !
Remember to tell your hospital that when this is all over & you are better.
GT1a Dec14 F2/8.7 VL 900000-2.5M
Jan16 Hepcivir-L MonkMed/Redemption
Baseline: VL 913575 Alt 76 Platelets low
Wk2 VL1157 Alt 23
DET Wk 8 VL 32 Alt19 'In the slow lane'
June16 Fibro 5.7 F0/1 LIF 1.5
Wk 11 VL<12 Alt 13 Det/Unq
Extending tx 12 wks Mylan Sofo/Dac MonkMed
Wk 14 VL <12 Det/Unq
Wk 16 VL UNDETECTED
Wk 22 + 4 Wks Sunprevir FixHepC
Wk 24 UNDETECTED Alt 13
Wk 12 post tx SVR12 Wk 26 SVR24
Thank-you Tim, Dr Debasis @ MonkMed & Dr Freeman @ Fix HepC

Dan's Twinvir story 7 years 1 day ago #9501

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Hi Dan,
Your LFT improved constantly during tx. You are on the right way. I am sure the VL will come after. :cheer:
We are not alone in this club, of slow responder. I think is related also with age. Sorry for my question, your age is? B)

In my case, I will finish the 12 weeks of tx. Hope I am not one of those 2-4%. Hey, we are GT 1b, easy to treat, no one have failed the DAA tx. :cheer:
But if it so, now there are other options, like SOF+DAC or SOF+DAC+SIM and other licensed Indian generics. It will cost extra money, it will be hard, but there are good alternatives.
Hope the best for your 8 week VL. #love And for mine too.
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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Dan's Twinvir story 7 years 1 day ago #9526

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Isaing4

Are you planning for 12 weeks, even if you are not UND by 10 weeks or will reconsider later?
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND

Dan's Twinvir story 7 years 1 day ago #9528

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Not sure if this was posted already. Interesting read.
www.hivandhepatitis.com/hcv-basic-scienc...erferon-free-therapy
Gen 1b, F1-F2. Naive.
Started Twinvir tx on 2 nd of December 2015 for 12 weeks.
Starting VL 400000, Alt 49/AST 44
1 week VL 29, ALT 44/AST 30.
4 weeks VL 12, ALT 33, Platelets 145, all other tests normal.
7 weeks VL Detected, ALT 28, all other normal
8 weeks UND, 12 week UND, 24 week SVR UND
The following user(s) said Thank You: Gaj, isaing4

Dan's Twinvir story 7 years 1 day ago #9530

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Dan wrote: Isaing4

Are you planning for 12 weeks, even if you are not UND by 10 weeks or will reconsider later?

Hi Dan,
For the moment I have in mind Dr. James patient VL example:
''To reassure you here are some real results from a patient of mine...
Week 0 7.8 million
Week 4 76
Week 5.5 < 15
Week 8 0
Week 12 0
SVR 4 0
SVR 12 0''
I have hope that my VL will have the same drop to UND!
If not UND at least < Lower Limit of Quantification (LLOQ), like in official trials. B)
Anyway, my viral load has dropped constantly during tx.
So, I think that I am still in the right direction towards cure, the desired SVR 4/12 !

Yes, in this moment of tx, I am convinced that 12 weeks are enough for me! :)

Best wishes and UND soon! #love
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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Dan's Twinvir story 7 years 1 day ago #9531

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Dan wrote: Not sure if this was posted already. Interesting read.
www.hivandhepatitis.com/hcv-basic-scienc...erferon-free-therapy

Very reassuring, from my perspective!
HCV since I don't know. Diagnosed in 2010.
GT1b, F0/F1, VL 9M, ALT 44, AST 42, Tx naive,
started 12 wks Twinvir on 06.12.2015. Feeling great and grateful :)
virus not detected 06.02.2016 & SVR24
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