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TOPIC: Voxilaprevir - A new Protease Inhibitor
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23795
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This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23796
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G3a since '78 - Dx '12 - F4 (2xHCC) 24wk Tx - PEG/Riba/Dac 2013 relapsed 24wk Tx - Generic Sof/Dac/Riba 2015/16 relapsed 16wk Tx - 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof SVR7 - 22/06/17 UND SRV12 - 27/07/17 UND SVR24 - 26/10/17 UND ![]() ![]() ![]() |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23797
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Gt 1a, F0, VL 6.5 million, AST 59, ALT 62 Started Twinvir 1/15/16 6 wk. labs VL UND, AST 27, ALT 20 EOT labs VL UND, AST 23, ALT 19 SVR 16, VL UND, AST 28, ALT 17 SVR 24 , VL UND, 10/8/16 SVR 125, VL UND, 9/22/18 SVR 230, VL UND, 10/3/20 |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 5 years 2 months ago #23798
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Gen 1b VL pre treatment 29000 ME/ml AST 32 ALT 94, F0 Started treatment 13 January 2017 Generic sofosbuvir/velpatasvir (Incepta) VL 9 days into treatment <300 (undetected) AST 13.8 ALT 22 Side effects: mild dehydration, not a problem at all if I drink water at night, nothing to worry about Diet and gastric ph are very important with velpatasvir. One must think what and when to eat to keep gastric pH low. Side effects disappeared 2 weeks after, unless I ate anything < 4hrs before the pill. SVR60. |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24564
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GT 1a (~1968) Diagnosed Non A/B ’85 – HCV ‘89 Rebetron INF/RBV 17 months 2000 – Failure Infergen INF/RBV 11 months 2002 – Failure Viekira Pak + RBV 12 weeks 2015 – Failure VL Und at +3 weeks > EOT – EOT+12 weeks 2,240k Resistance Tests – NS5a Q30R SMV/DCV/SOF + RBV 24 weeks 2016 VL Det <15 +2 and +4 weeks – Und +8 weeks > EOT SVR4, SVR12 and SVR24 Undetected |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24571
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YMMV |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24713
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This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24716
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YMMV |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24726
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This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 11 months ago #24733
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YMMV |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 10 months ago #24887
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GT 1a (~1968) Diagnosed Non A/B ’85 – HCV ‘89 Rebetron INF/RBV 17 months 2000 – Failure Infergen INF/RBV 11 months 2002 – Failure Viekira Pak + RBV 12 weeks 2015 – Failure VL Und at +3 weeks > EOT – EOT+12 weeks 2,240k Resistance Tests – NS5a Q30R SMV/DCV/SOF + RBV 24 weeks 2016 VL Det <15 +2 and +4 weeks – Und +8 weeks > EOT SVR4, SVR12 and SVR24 Undetected |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 10 months ago #24984
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This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 9 months ago #24991
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YMMV |
Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 9 months ago #24996
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Voxilaprevir (akaGS-9857) - A new Protease Inhibitor 4 years 9 months ago #24997
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This email address is being protected from spambots. You need JavaScript enabled to view it. Genotype 3 VL 4,100,000 ALT 101 AST 71 Treatment Naive Started Sof/Dac Jan 12, 2016 VL= <15 4 weeks in. AST/ALT normal. VL=UNDETECTED 8 weeks in. SVR4= Virus back. 3,300,000 Started generic Epclusa Sep. 23, 2017 4 weeks in <15 *Detected. 12 weeks in <15 *Not Detected. 16 weeks in <15 *Not Detected. Finished 24 weeks treatment 3-17-18 SVR5 <15 Not Detected. SVR 20 <15 Not Detected. SVR 44 <15 Not Detected. Thank you Jesus. Thank you Dr. James |