Hi miko3,

The trials have been done and the evidence is in. What’s left is the age-old dilemma:
What to choose, the bird in the hand or the two in the bush?
Good luck with that.

dt

I agree crazy8.
And this opens up a whole new customer base for the generics. It needn’t be either/or. All the people who have been doled out 12 weeks of brand name drugs by their health service or their insurance company can choose to supplement to 24 weeks by purchasing their own additional 12 weeks. And it needn’t be the same as the first 12 weeks. For example, if you got sof/led for 12 weeks you could supplement with sof/dac for the other 12, or whatever else was recommended in your case. One thing is for sure. You’ll not have so many hoops to jump through getting your generics as you will have to get your health service and insurance to cough up.
dt

I think the consensus in this discussion is that given the cheaper cost of generics,overkill is a desirable option,not offered by insurers,Health funds etc..The conclusion would therefore be that Hamiltons tx regime,although out of the ordinary makes sense and has an outside chance of being more cost effective in the long run.
Dointime you quote
“And it needn’t be the same as the first 12 weeks. For example, if you got sof/led for 12 weeks you could supplement with sof/dac for the other 12,”
Are you absolutely sure of this Dointime,or is there a hidden downside to changing.I have no reason to doubt you.Both are Ns/5A inhibitors,but seem to have a slightly different pharmacology.Led seems to have a marginally better performance success than Dac,but this might be just a statistical wobble.Is there anyone that can add any insight into this?I have posed this question earlier.

I guess the other issue in this discussion is that many of us look at this new DAA tx/concept from previous tx experiences and older knowledge. I think it would be true to say that if you clear in 4 UND the chances of this virus returning is less than the 5% data presented in all the trials data and this really flows well with previous regimes and knowledge. However, as Dr Freeman pointed out in previous posts (linked to the research) people who have not cleared until the final week (12) of tx but go onto SVR post 12 weeks. What I do know is that once these DAAs do there job there is little chance of the virus rebounding. I’d like to see some detailed data on percentage of failures based on non-response vs relapse. Also I’d like to see data on percentages based on genotype, I haven’t seen too much of this based on the collective research. Em

Welcome to the discussion Lisa KT.You are indeed a hardened warrior.As someone who is treatment naive I cant even
start to imagine the hell some of you guys have gone through.Hope it works this time.Would it be appropriate to ask
where,or by whom your tx regime was suggested?
DT
It would seem logical if one were to make a change to go for a sof simeprevir regime where you are changing to a NS3A/4A Inhibitor.However,I don’t know of any sources of generic simeprevir.It would be interesting to know if they exist.It is actually on the PBS in australia,but only for use in a combination with peg inf.My specialist told me he had a heap of inmates on the local prison on this combo,because none of them had any money to afford generics.
I actually discussed with my specialist at the start of tx a combination of Sof led sim in order to eliminate riba,which at the time I had a great fear of after reading just too many reports on various forums..He said he had one wealthy patient on this combo who had very advanced cirrhosis.But the patient had accessed the sof led as generics and paid $25000 himself for the 12wk course of simeprevir.
His advice to me was to take sof dac riba for 12wks and if I couldn’t handle the riba just to drop it and go buy an extra 12wks of sof dac,
As it has turned out the reports on riba in my case were totally exagerated.I wouldn’t describe it as a party drug,but the side effects have proved to be very minimal.I still manage a circuit of the local mountain bike track every morning and my times are much the same.

Don’t wish to rain on your parade miko, but Riba sides normally kick in at about 9 or 10 weeks (anaemia = fatigue). But not everyone gets it. Hopefully, you’re the latter.

Thanks a lot Alsdad,thats just about going to make it a great xmas present.