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  • 1 January 2016 at 7:40 am #7670
    Avatar photoflyingfox66
    • Guardian Angel
    • ★★★★★
    @flyingfox66

    God sake if it really is a cost cutting measure its an incredibly petty and nasty one!
    I can’t help thinking anyone with a speck of human compassion would want to chuck the Interferon on the incinerator asap.
    Perhaps the people who make these decisions just never get to see what happens at ground zero? It’s the only way I can imagine they aren’t monsters.

    F49HepC25ysGT1a
    mild”

    2 January 2016 at 12:28 am #7745
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    Hi Joy, aaaaaaaaa, that’s just the same old tired mantra that the US FDA uses for GT 2’s. Europe I believe years ago figured out you can cure GT 2’s with sofosbuvir and daclatasvir without ribavirin.

    I have read that the only reason this persists as the “approved” treatment for GT 2’s is that there are so few of us (relative to the other genotypes) that none of the big outfits have decided it was worthwhile to invest the money to test out the efficacy of dac and sof on GT2s, so the ribavirin recommendations remain just because of cheapness and the lack of investment in trials on GT 2’s.

    Unless there is some aggravating condition , like cirrhosis or something, I believe GT2s can do fine without ribavirin. I am, I was clear at 4 weeks without it.

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    2 January 2016 at 2:39 am #7760
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Nice to see you over at hepmag as comrade-in-arms to Coach Mike, 2b :)

    (at least I’m pretty sure its you Lol)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    2 January 2016 at 2:45 am #7761
    Joan
    • Topics: 3
    • Replies: 68
    • Total: 71
    • Recovery Champion
    • ★★★★
    @joan

    My thoughts on GT2’s getting around Ribavirin.

    Go to a very supportive GP.

    Explain the difference between Ribavirin and Daclastivir and how the body responds and the side effects.

    Explain that there are GT2’s who have and are responding to Sof/Dac and at 4 weeks have responded UND.

    Insist that you get a script of Sof/Dac and that you have done your research and if they are in doubt ask them to look at FixHepC website and look at the facts around treatment for GT2’s on Sof/Dac.

    GT2B Diagnosed 1989
    Started Tx 6.Nov.2015
    F3 Fibroscan 17: April.2015
    Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
    Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015

    2 January 2016 at 8:48 am #7784
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    Aye Mate, it is me, 2B, over there, guarding the flank!

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    2 January 2016 at 10:47 am #7794
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Glad to hear it, Comrade! Hey at least you won’t need the claymores left over from the delphi forums skirmish :lol:

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    2 January 2016 at 11:42 pm #7846
    Avatar photo2b
    • Guardian Angel
    • ★★★★★
    @2b

    Oh I’m still maintaining surveillance over those flat-earth holy rollers–if I see them start misleading people again like they were, I’ll have to assume a new identity and dig up the munitions and wade back in there. They seem to have calmed down for the time being, haven’t seen any anti-generic rants on there for awhile now, but I’ll keep an eye on em.

    GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””

    5 January 2016 at 2:18 am #8001
    Joan
    • Topics: 3
    • Replies: 68
    • Total: 71
    • Recovery Champion
    • ★★★★
    @joan

    Hello G2’s

    Just to clarify I made a few enquiries at the clinic regarding my Genotype and I am GT2b also my viral load was Undetected which I assumed was 0. So thats clear. The finer details of this language is fairly new to me and I am learning as I go via this forum.
    Also recently learnt how to do my signature. Still trying towok out the smilies.

    Thanks to all of you

    GT2B Diagnosed 1989
    Started Tx 6.Nov.2015
    F3 Fibroscan 17: April.2015
    Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
    Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015

    5 January 2016 at 2:28 am #8003
    avatar876.jpegGaj
    • Guardian Angel
    • ★★★★★
    @gaj

    Congratulations on your UNdetected, Joan! That must be a great feeling. :)

    (Just click or tap the smilie you want from the group above the box where you type the message)

    G3a since ’78 – Dx ’12 – F4 (2xHCC)
    24wk Tx – PEG/Riba/Dac 2013 relapsed
    24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
    16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
    SVR7 – 22/06/17 UND
    SRV12 – 27/07/17 UND
    SVR24 – 26/10/17 UND
    :cheer: :cheer: :cheer:

    5 January 2016 at 2:40 am #8005
    Avatar photoIRMA88
    • Topics: 2
    • Replies: 39
    • Total: 41
    • Recovery Champion
    • ★★★★
    @irma88

    Congratulations Joan! Great news :)

    G2B – DIAGNOSED 2014, STARTED SOF/DAC 11/11/15 VL 6M
    UND @ WEEK4
    FINISHED TREATMENT 26/4/16
    UND @ WEEK 24
    ALT 12 AST 15
    MY ETERNAL GRATITUDE TO GREG JEFFERYS & DR FREEMAN

    5 January 2016 at 11:39 am #8023
    Avatar photozhuk
    • Guardian Angel
    • ★★★★★
    @zhuk

    Fantastic news, Joan! Great to hear, congratulations :)

    GT1a since 1988, diagnosed 1990
    F0, tx naive
    VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
    Started Mesochem sof/dac 12 weeks 01/01/2016
    11/02/2016 – 6 weeks UNDETECTED
    AST 26
    ALT 26

    5 January 2016 at 12:09 pm #8028
    Avatar photoJaz
    • Topics: 2
    • Replies: 81
    • Total: 83
    • Guardian Angel
    • ★★★★★
    @jaz

    Congratulations Joan! Excellent news!

    3a F0 TX Naive
    Started Tx 12/12/2015 Kingswood Sof/Dac

    Pre Tx – ALT 71 AST 40 V/L 9 million
    Day 11 – ALT 12 AST 15
    4 week – LFTs normal – detected (same sample sent for v/l showed undetected) :/
    6 week – UND
    12 week EOT – UND
    SVR4
    SVR12

    5 January 2016 at 2:36 pm #8031
    Avatar photoJoy
    • Guardian Angel
    • ★★★★★
    @joy

    Yes really fantastic news Joan!

    smile smile smile smile smile smile smile smile smile smile smile smile smile smile smile

    I still haven’t learned how to line up the smilies. :oops:

    20 February 2016 at 4:03 am #12299
    LLJ
    • Topics: 0
    • Replies: 6
    • Total: 6
    • Novice
    • ★
    @llj

    Hi, I just joined this board today. I’m another 2b, and am Fibrosure Stage 4. I’m in the US and am treating with 16 weeks of sovosbuvir and Ribavirin x16 weeks (16 because of fibro score). We are pretty uncommon here, too. I tell people that I have the posh European genotype because I got it when I lived in Great Britain.

    LLJ

    Geno 2b; Fibrosure 4. Tx: sovosbuvir/ribavirin x 16 weeks. EOT March 4, 2016
    0 weeks: RNA = 10012000 iu/ml; log10 = 7.001. AST 129; ALT 133
    4 weeks: PCR Quantitation = 60 iu/ml; log10 = 1.778. 5 weeks: PCR Quantitation < 15 (UND); AST 35; ALT 24

    20 February 2016 at 10:34 am #12317
    Avatar photosplitdog
    • Guardian Angel
    • ★★★★★
    @splitdog

    I would think about adding Daclatasvir to that. Couldn’t hurt, that’s for sure.

    splitdog@roadrunner.com

    Genotype 3
    VL 4,100,000
    ALT 101 AST 71
    Treatment Naive
    Started Sof/Dac Jan 12, 2016
    VL= <15 4 weeks in. AST/ALT normal.
    VL=UNDETECTED 8 weeks in.
    SVR4= Virus back. 3,300,000

    Started generic Epclusa Sep. 23, 2017

    4 weeks in <15 *Detected.
    12 weeks in <15 *Not Detected.
    16 weeks in <15 *Not Detected.
    Finished 24 weeks treatment 3-17-18
    SVR5 <15 Not Detected.
    SVR 20 <15 Not Detected.
    SVR 44 <15 Not Detected.

    Thank you Jesus.
    Thank you Dr. James

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