2B HERE - FixHepC

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1 January 2016 at 7:40 am #7670
flyingfox66
- Topics: 2
- Replies: 170
- Total: 172
- Guardian Angel
@flyingfox66
God sake if it really is a cost cutting measure its an incredibly petty and nasty one!
I can’t help thinking anyone with a speck of human compassion would want to chuck the Interferon on the incinerator asap.
Perhaps the people who make these decisions just never get to see what happens at ground zero? It’s the only way I can imagine they aren’t monsters.

F49HepC25ysGT1a
mild”
2 January 2016 at 12:28 am #7745
2b
- Topics: 17
- Replies: 332
- Total: 349
- Guardian Angel
@2b
Hi Joy, aaaaaaaaa, that’s just the same old tired mantra that the US FDA uses for GT 2’s. Europe I believe years ago figured out you can cure GT 2’s with sofosbuvir and daclatasvir without ribavirin.

I have read that the only reason this persists as the “approved” treatment for GT 2’s is that there are so few of us (relative to the other genotypes) that none of the big outfits have decided it was worthwhile to invest the money to test out the efficacy of dac and sof on GT2s, so the ribavirin recommendations remain just because of cheapness and the lack of investment in trials on GT 2’s.

Unless there is some aggravating condition , like cirrhosis or something, I believe GT2s can do fine without ribavirin. I am, I was clear at 4 weeks without it.

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
2 January 2016 at 2:39 am #7760
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Nice to see you over at hepmag as comrade-in-arms to Coach Mike, 2b

(at least I’m pretty sure its you Lol)

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
2 January 2016 at 2:45 am #7761
Joan
- Topics: 3
- Replies: 68
- Total: 71
- Recovery Champion
@joan
My thoughts on GT2’s getting around Ribavirin.

Go to a very supportive GP.

Explain the difference between Ribavirin and Daclastivir and how the body responds and the side effects.

Explain that there are GT2’s who have and are responding to Sof/Dac and at 4 weeks have responded UND.

Insist that you get a script of Sof/Dac and that you have done your research and if they are in doubt ask them to look at FixHepC website and look at the facts around treatment for GT2’s on Sof/Dac.

GT2B Diagnosed 1989
Started Tx 6.Nov.2015
F3 Fibroscan 17: April.2015
Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015
2 January 2016 at 8:48 am #7784
2b
- Topics: 17
- Replies: 332
- Total: 349
- Guardian Angel
@2b
Aye Mate, it is me, 2B, over there, guarding the flank!

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
2 January 2016 at 10:47 am #7794
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Glad to hear it, Comrade! Hey at least you won’t need the claymores left over from the delphi forums skirmish

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
2 January 2016 at 11:42 pm #7846
2b
- Topics: 17
- Replies: 332
- Total: 349
- Guardian Angel
@2b
Oh I’m still maintaining surveillance over those flat-earth holy rollers–if I see them start misleading people again like they were, I’ll have to assume a new identity and dig up the munitions and wade back in there. They seem to have calmed down for the time being, haven’t seen any anti-generic rants on there for awhile now, but I’ll keep an eye on em.

GT 2b; since 80’s, no prior tx, sofosbuvir and daclatasvir compounded from API’s at Kingswood Pharmacy in Sydney, started tx nov 6,2015, undetected at 4 wks, UND at 8 weeks, UND at 1 week after EOT, UND at 4 weeks after EOT and UND at 8 weeks after EOT. I feel GOOD!! I knew that I WOULD!””
5 January 2016 at 2:18 am #8001
Joan
- Topics: 3
- Replies: 68
- Total: 71
- Recovery Champion
@joan
Hello G2’s

Just to clarify I made a few enquiries at the clinic regarding my Genotype and I am GT2b also my viral load was Undetected which I assumed was 0. So thats clear. The finer details of this language is fairly new to me and I am learning as I go via this forum.
Also recently learnt how to do my signature. Still trying towok out the smilies.

Thanks to all of you

GT2B Diagnosed 1989
Started Tx 6.Nov.2015
F3 Fibroscan 17: April.2015
Alt PreTx: 186 Ast PreTx: 157 VL PreTx: 733,000 27.10.2015
Alt Week 4: 14 Ast Week 4: 28 VL Week 4: UND 7.12.2015
5 January 2016 at 2:28 am #8003
Gaj
- Topics: 29
- Replies: 1,402
- Total: 1,431
- Guardian Angel
@gaj
Congratulations on your UNdetected, Joan! That must be a great feeling.

(Just click or tap the smilie you want from the group above the box where you type the message)

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
5 January 2016 at 2:40 am #8005
IRMA88
- Topics: 2
- Replies: 39
- Total: 41
- Recovery Champion
@irma88
Congratulations Joan! Great news

G2B – DIAGNOSED 2014, STARTED SOF/DAC 11/11/15 VL 6M
UND @ WEEK4
FINISHED TREATMENT 26/4/16
UND @ WEEK 24
ALT 12 AST 15
MY ETERNAL GRATITUDE TO GREG JEFFERYS & DR FREEMAN
5 January 2016 at 11:39 am #8023
zhuk
- Topics: 5
- Replies: 543
- Total: 548
- Guardian Angel
@zhuk
Fantastic news, Joan! Great to hear, congratulations

GT1a since 1988, diagnosed 1990
F0, tx naive
VL 262,000 ALT 40 AST 26 GGT 13 Fibroscan 04/12/15 – 2.9
Started Mesochem sof/dac 12 weeks 01/01/2016
11/02/2016 – 6 weeks UNDETECTED
AST 26
ALT 26
5 January 2016 at 12:09 pm #8028
Jaz
- Topics: 2
- Replies: 81
- Total: 83
- Guardian Angel
@jaz
Congratulations Joan! Excellent news!

3a F0 TX Naive
Started Tx 12/12/2015 Kingswood Sof/Dac

Pre Tx – ALT 71 AST 40 V/L 9 million
Day 11 – ALT 12 AST 15
4 week – LFTs normal – detected (same sample sent for v/l showed undetected) :/
6 week – UND
12 week EOT – UND
SVR4
SVR12
5 January 2016 at 2:36 pm #8031
Joy
- Topics: 12
- Replies: 206
- Total: 218
- Guardian Angel
@joy
Yes really fantastic news Joan!

smile smile smile smile smile smile smile smile smile smile smile smile smile smile smile

I still haven’t learned how to line up the smilies. ops:
20 February 2016 at 4:03 am #12299
LLJ
- Topics: 0
- Replies: 6
- Total: 6
- Novice
@llj
Hi, I just joined this board today. I’m another 2b, and am Fibrosure Stage 4. I’m in the US and am treating with 16 weeks of sovosbuvir and Ribavirin x16 weeks (16 because of fibro score). We are pretty uncommon here, too. I tell people that I have the posh European genotype because I got it when I lived in Great Britain.

LLJ

Geno 2b; Fibrosure 4. Tx: sovosbuvir/ribavirin x 16 weeks. EOT March 4, 2016
0 weeks: RNA = 10012000 iu/ml; log10 = 7.001. AST 129; ALT 133
4 weeks: PCR Quantitation = 60 iu/ml; log10 = 1.778. 5 weeks: PCR Quantitation < 15 (UND); AST 35; ALT 24
20 February 2016 at 10:34 am #12317
splitdog
- Topics: 5
- Replies: 374
- Total: 379
- Guardian Angel
@splitdog
I would think about adding Daclatasvir to that. Couldn’t hurt, that’s for sure.

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
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