Genotype 3's info, updates corner

This topic has 119 replies, 35 voices, and was last updated 6 years, 5 months ago by splitdog.

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15 March 2017 at 8:44 pm #25596
Donna
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- Total: 71
- Recovery Champion
@donna
Just had my results 14 weeks EOT
Negative for Hep C
Thanks Dr Freeman
15 March 2017 at 11:30 pm #25597
splitdog
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- Total: 379
- Guardian Angel
@splitdog
Good for you!!!!!

splitdog@roadrunner.com

Genotype 3
VL 4,100,000
ALT 101 AST 71
Treatment Naive
Started Sof/Dac Jan 12, 2016
VL= <15 4 weeks in. AST/ALT normal.
VL=UNDETECTED 8 weeks in.
SVR4= Virus back. 3,300,000

Started generic Epclusa Sep. 23, 2017

4 weeks in <15 *Detected.
12 weeks in <15 *Not Detected.
16 weeks in <15 *Not Detected.
Finished 24 weeks treatment 3-17-18
SVR5 <15 Not Detected.
SVR 20 <15 Not Detected.
SVR 44 <15 Not Detected.

Thank you Jesus.
Thank you Dr. James
17 March 2017 at 2:58 am #25611
Paul-Jarman-facebook
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- Guardian Angel
@paul-jarman-facebook
Good news Donna another one cured

Two time relapser.

SVR 4 achieved 12/16 at last
SVR 12 achieved 22/02/2017 The Bastard has been defeated

GT 3 – about 28 yrs with HCV
20 April 2017 at 12:34 pm #25886
gypsy
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- Recovery Champion
@gypsy
I can’t wait to start. I want to get my fibroscan and have doctor prescribe so I can get in on the studies. I have had most tests done. Thankfully the two listed on this site are good and affordable. I have type 3A. My scan is in one month. It is cheaper for me to go to Canada to get this as I do not need doctor appointments for it. I hope to see updates on your progress.
20 April 2017 at 2:32 pm #25887
Mnem
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@mnem
Hi Gypsy, This is an exciting time for you, you must be full of anticipation. Good that you do not have to wait long until you get your fibroscan, you’re fortunate to be able to access that technology. As a longtime HCV+ve person who endured multiple old liver punch biopsies, I was relieved when the far more comfortable fibroscanning became available.
I am looking forward to reading your progress reports over the next weeks and months. You are on your way!

G2, infected maybe in 1971?
Diagnosed HVnon-A non-B 1980s, revised to HVC 1990’s.
Treatment naive. Fibroscan & bloods all normal ranges.
Viral load 7million,
began Redemption trial4, 12-week generic Sof/Vel (Incepta) 2017. Week 4 UND, Week 12UND, SVR24
Thank-yous to my doctor for the script, to Jan at FixHepC for wrangling, and to Dr Freeman for courage.
Kia kaha e hoa ma!
21 April 2017 at 11:51 am #25894
coral
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@coral
Hi Gypsy,

Good to see that you are heading towards your start date. I know what you mean about not wanting to wait. Once I heard about the treatment and how quickly, easily and cheaply I could access it I couldn’t wait to just do it. Good luck and I’m looking forward to hearing about how you are travelling.
18 May 2017 at 1:53 pm #26103
gypsy
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- Recovery Champion
@gypsy
I got my Rx through Dr . Freeman and they were shipped and are now in New York (customs I suppose). Fibroscan is this next week. Looking forward to results. Going to Canada which is at least a 7 hr trip or longer. Cant wait to get started.
18 May 2017 at 1:56 pm #26104
gypsy
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- Recovery Champion
@gypsy
Yay!!Yahoo!! Congratulations!
22 May 2017 at 9:26 am #26113
Gert
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- Recovery Champion
@gert
Hi James Feemann

Treatment of GT3 in Denmark:

I have a question for you regarding genotype 3
Have the Danish health authorities paid the following treatment:
Sofosbuvir 400 mg & Velpatasvir 100 mg or
Sofosbuvir 400 mg & Daclatasvir 60 mg.

Are there any studies whether there are differences in the effect of the two types of treatment?

greeting
Gert

Probably infected 30 years ago Genotype: 1a
Fibroscan 4,8 – 18 january 2017
Virus in the blood 18 January 2017 10.400000 / Alat 102
Started treatment January 19, 2017
Feb.15 – Alat 76 – virus: UNDETECTED
March 15 – Alat 34 – virus UNDETECTED
April 12 – Alat 40 Asat 34 – virus UNDETECTED / Taking the last pill
May 10 SVR4 – Alat 36 -virus UNDETECTED
July 5 SVR12 – Fibroscan 3,8 Alat 39 – virus UNDETECTED
Sep. 27 SVR24 – ALAT 24- virus UNDETECTED
Marts 14 – 2018 SVR48 – ALAT 26- virus UNDETECTED
22 May 2017 at 1:04 pm #26119
Dr James
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- Guardian Angel
@fixhepc
Hello Gert,

Yes, there are studies. You want page 18 of the EASL Guidelines (see PDF) that reports the major studies used for the guidelines and provides references for them you can then look up.

SOF+VEL: ASTRAL-3

Short version: http://slides.hcvonline.org/uploads/194/astral3.pdf
Long version: http://www.nejm.org/doi/full/10.1056/NEJMoa1512612#t=article

SOF+DCV: ALLY-3 and ALLY-3+

Short version: http://slides.hcvonline.org/uploads/164/ally3.pdf
Long vesion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409820/

ALLY-3+ https://www.ncbi.nlm.nih.gov/pubmed/26822022

There is another bigger SOF+DCV trial here: http://fixhepc.com/forum/gt3/369-gt3-high-svr-rates-with-daclatasvir.html which includes a PDF of the results. It does not have a funky name AFIK.

You may notice that the results for SOF+DCV vary a bit and include similar optimistic numbers to SOF+VEL

Now this table is interesting (and you won’t easily find it). It comes from Abbvie who were talking about how good G/P is (previously called ABT-493/ABT-530). GS-9857 is Voxilaprevir in case you’re wondering.

In theory Velpatasvir should be better – It has an EC50 of 20 vs 530 for daclatasvir, but only about 25% gets absorbed so that robs it of part of the 26.5x theoretical edge, dropping it to say 7x, but then the dose is 100 mg vs 60 mg so that pushes it up to about 10x.

Now resistance comes in 10x, 100x and 1000x strengths so 10x is just enough to probably make a real difference for a few patients.

I have no doubt that 16 weeks SOF+DCV works better in GT3 patients than 12 weeks, so that is a factor.
Attachments:
- EASLEnglish-report.pdf
YMMV
31 May 2017 at 11:42 pm #26248
gypsy
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- Recovery Champion
@gypsy
I am genotype 3A and have been generic epclusa only a little over a week. My fibroscan looked normal. The first few days I felt kind of off but take it at night now and am noticing improvement in energy off and on.
27 November 2017 at 1:23 pm #27062
MWILLIAMS
- Topics: 1
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- Novice
@mwilliams
Hi I’m genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.
27 November 2017 at 1:24 pm #27063
MWILLIAMS
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- Novice
@mwilliams
MWILLIAMS wrote:

Hi I’m genotype 3 have been positive for 18 years, no scarring shown on fibroscan, no past treatment, and am about to start sofosbuvir and daclatasvir.
27 November 2017 at 1:40 pm #27064
Dr James
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@fixhepc
Welcome MWILLIAMS, that’s a good treatment. Chances are good it will cure you.

YMMV
27 November 2017 at 1:47 pm #27066
MWILLIAMS
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- Novice
@mwilliams
Thanks. I’ve been waiting a long time for a cure and now that I have the treatment I’m a bit anxious to take it
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