Incase of Harvoni relapse whats next ?

This topic has 42 replies, 11 voices, and was last updated 8 years, 2 months ago by Dr James.

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21 December 2015 at 4:06 pm #6938
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
The Mesochem APIs are pure. You can’t know if you are SVR 12 until 12 weeks after you stop treatment. If the virus is present at that point, the entire process starts from the beginning.

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 December 2015 at 4:12 pm #6939
mgalbrai
- Topics: 28
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- Guardian Angel
@mgalbrai
Hi D,
Do you mean if you are UNDETECTED at week 12, you will continue? Were you undetected at week 4? If so, you should be undetected as long as you are taking the meds.
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 December 2015 at 4:26 pm #6945
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
Its been just 11 days for me on the meds. No I mean I will continue for 16 weeks BUT after 12 weeks if I have achieved SVR then I will stop after 16 weeks.

But If I am UD at 4 and again at 8 weeks I think I am sorted
For me the side effects on Harvoni have been nothing too serious BUT I dont want to add Riba at any stage.

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
21 December 2015 at 4:31 pm #6948
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
Enkel wrote:

UP TO NOW AT 700USD PER BOTTLE

https://www.zauba.com/import-harvoni-hs-code.html

If someone imports at $ 700 will he sell at $ 700 ?

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
21 December 2015 at 4:34 pm #6949
Enkel
- Topics: 16
- Replies: 293
- Total: 309
- Guardian Angel
@enkel
I dont know but I have been offered in indiamart original harvoni for 700USD. But i cant trust them

Male, Fibro F1. Geno 1b. ALT 67 before treatment Viral load 5 million. My huge viral load replicates in my nervous system as I suffer anxiety.
Started Twinvir 12/12/15.
Two weeks
ALT 17 at 2 weeks
Viral Load UND at 2 weeks
ALT 13.5 at 7 weeks EOT
ALT 10.5 at 15 weeks EOT
ALT 13 at 27 weeks EOT, VL UND, Cured
21 December 2015 at 4:39 pm #6950
sonix
- Topics: 7
- Replies: 158
- Total: 165
- Guardian Angel
@sonix
darbara wrote:

Its been just 11 days for me on the meds. No I mean I will continue for 16 weeks BUT after 12 weeks if I have achieved SVR then I will stop after 16 weeks.

As 86 said, you can’t have SVR while you are still on meds. SVR is Sustained Virological Response measured after end of treatment (EOT). You are confusing SVR with UND (Undetected). If you are UND after 4 weeks on meds you almost certainly will be UND after 12 weeks of meds. But for SVR12 you need to be UND 12 weeks after finishing taking meds.

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
21 December 2015 at 4:51 pm #6953
darbara
- Topics: 6
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- Total: 172
- Guardian Angel
@darbara
OK so we are back to square 1 or incase of my fear I take it for 24 weeks and then wait 12 more to see if I have achieved SVR.
So confused now BUT I got it SVR is only got after finishing treatment and that too 12 weeks after that
So the entire process is 24 weeks.
Sorry guys I am not a native English speaker sometimes is difficult to understand. My apologies.

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
21 December 2015 at 5:02 pm #6955
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Hey D,
No apologies needed. The main thing is you got it!!!
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 December 2015 at 5:09 pm #6959
sonix
- Topics: 7
- Replies: 158
- Total: 165
- Guardian Angel
@sonix
Ditto, no apology necessary.
I was pretty confused with all the jargon when I first started looking into this and learned lots more in the couple of weeks I’ve been on this forum. Still get confused!
I think Dr James posted elsewhere that treatment should be longer if you are F4.
Edit – I see he posted while I was writing this.

M 61yo HCV+ ~ 30 yrs Gt1a F2 VL 223,000 ALT 54 AST 42 Tx start Sof/Dac 17Dec15.
SVR4 at 7Apr16 ALT 22 AST 22
SVR12 at 9Jun16 ALT 23 AST 25
Melbourne, Australia
21 December 2015 at 5:10 pm #6960
Dr James
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- Guardian Angel
@fixhepc
You need to take 24 continuous weeks of treatment to achieve the best results.

If you take 12 weeks your success rate will be ~ 85% ie 15% fail rate (1:6) 1 chance in 6 of relapse

If you take 24 weeks your success rate will be ~ 95% ie 5% fail rate (1:20) 1 chance in 20 of relapse

1:20 is much better odds than 1:6

We assess treatment success in the weeks following FINISHING treatment

SVR4 = Undetectable (UND) 4 weeks after treatment stops and means 96% chance permanent cure
SVR12 = Undetectable (UND) 12 weeks after treatment stops and means 99% chance permanent cure
SVR24 = Undetectable (UND) 24 weeks after treatment stops and means 99.8% chance permanent cure

YMMV
21 December 2015 at 5:14 pm #6962
darbara
- Topics: 6
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- Total: 172
- Guardian Angel
@darbara
Thanks guys. I have my bloods after 18 days and then MRI of the upper abdomin so lets see how it goes. Its my state that pays so they will go all the way to help me. Thank God its no Insurance as then the finance part THEN comes in.
My fibroscan showed 26 kpa but the doc could not be sure of cirrhosis and I did NOT want a biopsy so now hes doing the MRI AND NO bloody IDEA from where I got this damn HCV

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
21 December 2015 at 5:17 pm #6963
Gaj
- Topics: 29
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- Guardian Angel
@gaj
No apologies needed.

But….with F3/4 fibrosis 12 weeks of Harvoni will give mid 80-90% chance of cure.. 24 weeks of harvoni will give better chance of cure. So if you don’t want to use Ribavirin then you can do 24 weeks of Harvoni to give the same or even better result than Ribavarin. But it will cost more. You could try 16 or 20 weeks too, but I can not advise which would be best for you.

Edit: I see Dr Freeman recommends.24 weeks for ~ 95%

G3a since ’78 – Dx ’12 – F4 (2xHCC)
24wk Tx – PEG/Riba/Dac 2013 relapsed
24wk Tx – Generic Sof/Dac/Riba 2015/16 relapsed
16wk Tx – 12/01/17 -> 03/05/17 NS3/NS5a + Generic Sof
SVR7 – 22/06/17 UND
SRV12 – 27/07/17 UND
SVR24 – 26/10/17 UND
21 December 2015 at 5:49 pm #6969
darbara
- Topics: 6
- Replies: 166
- Total: 172
- Guardian Angel
@darbara
I guess treatment Naive makes no difference if your fibroscan score is so high

Treatment naive
F 3/4
Genotype 1 a & b
V/L 17 MILLION
Started Harvoni 11th Dec 2015 for 12 weeks
4 weeks VL UND
6 WEEKS ALT 32, AST 34
EOT 03/03 2016 ! UND
ALT 34, AST 26
04.04.2016 SVR 4
26.05.2016 SVR 12
16.08.2016 SVR 24
21 December 2015 at 5:51 pm #6971
mgalbrai
- Topics: 28
- Replies: 1,298
- Total: 1,326
- Guardian Angel
@mgalbrai
Yes D,
That is correct from my understanding.
Mike

Curehcvnow@gmail.com
http://forums.delphiforums.com/generichcvtx

G 1a F-1
Started tx 10/23/15 (Meso sof & led) ALT 48 AST 28 v/l 1.6 mil
11/17/15 4 wk lab ALT 17 AST 16 <15
11/18/15 Started Harvoni
12/16/15 8 wk lab ALT: 15 AST: 13 V/l UND
1/14/16 Fin. Tx
7/07/16 UND SVR 24
21 December 2015 at 6:09 pm #6973
Dr James
- Topics: 264
- Replies: 1,968
- Total: 2,232
- Guardian Angel
@fixhepc
Take 24 weeks treatment. God smiles on those who take 24 weeks more often, so sayeth the statisticians.

YMMV
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